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    Tbc1d2b TBC1 domain family, member 2B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315880, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Tbc1d2bprovided by RGD
    Official Full Name
    TBC1 domain family, member 2Bprovided by RGD
    Primary source
    RGD:1307436
    See related
    Ensembl:ENSRNOG00000014543 AllianceGenome:RGD:1307436
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1307436
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in activation of GTPase activity and intracellular protein transport. Predicted to be located in cytosol. Orthologous to human TBC1D2B (TBC1 domain family member 2B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 223.9), Spleen (RPKM 124.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tbc1d2b in Genome Data Viewer
    Location:
    8q31
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (99626019..99694669, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (90746220..90814867, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (97577551..97647072, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene transfer RNA lysine (anticodon CUU) 18 Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif, 7 Neighboring gene translocase of outer mitochondrial membrane 7, pseudogene 1 Neighboring gene uncharacterized LOC134479983

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Functional dissection of Rab GTPases involved in primary cilium formation. Yoshimura S, et al. J Cell Biol, 2007 Jul 30. PMID 17646400, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in activation of GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT involved_in regulation of cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    TBC1 domain family member 2B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001413794.1 → NP_001400723.1  TBC1 domain family member 2B

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I6ALB6
      Related
      ENSRNOP00000093906.1, ENSRNOT00000119718.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      99626019..99694669 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063265567.1 → XP_063121637.1  TBC1 domain family member 2B isoform X3

    2. XM_039081539.2 → XP_038937467.1  TBC1 domain family member 2B isoform X2

      UniProtKB/TrEMBL
      A6I221, D3ZAF7
      Conserved Domains (2) summary
      COG1196
      Location:109 → 338
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam00566
      Location:435 → 646
      RabGAP-TBC; Rab-GTPase-TBC domain

    3. XM_039081538.2 → XP_038937466.1  TBC1 domain family member 2B isoform X1

      UniProtKB/TrEMBL
      A6I221, D3ZAF7
      Conserved Domains (3) summary
      COG1196
      Location:339 → 568
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd01265
      Location:36 → 144
      PH_TBC1D2A; TBC1 domain family member 2A pleckstrin homology (PH) domain
      cl02495
      Location:659 → 799
      RabGAP-TBC; Rab-GTPase-TBC domain
    Nucleotide Protein Strain
    Heading Accession and Version

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