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    Raver1 ribonucleoprotein, PTB-binding 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 298705, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Raver1provided by RGD
    Official Full Name
    ribonucleoprotein, PTB-binding 1provided by RGD
    Primary source
    RGD:1359190
    See related
    Ensembl:ENSRNOG00000020710 AllianceGenome:RGD:1359190
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Raver1h
    Summary
    Predicted to enable mRNA binding activity. Predicted to be involved in regulation of alternative mRNA splicing, via spliceosome. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Orthologous to human RAVER1 (ribonucleoprotein, PTB binding 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 109.3), Spleen (RPKM 87.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Raver1 in Genome Data Viewer
    Location:
    8q13
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (27886641..27907192, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (19610464..19629188, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (22092084..22111863, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene zinc finger, GATA-like protein 1 Neighboring gene ferredoxin 2 Neighboring gene tyrosine kinase 2 Neighboring gene uncharacterized LOC108351660

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The PTB interacting protein raver1 regulates alpha-tropomyosin alternative splicing. Gromak N, et al. EMBO J, 2003 Dec 1. PMID 14633994, Free PMC Article
    2. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ribonucleoprotein PTB-binding 1
    Names
    RAVER1 homolog
    protein raver-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013939.1 → NP_001013961.1  ribonucleoprotein PTB-binding 1

      See identical proteins and their annotated locations for NP_001013961.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083865
      UniProtKB/Swiss-Prot
      Q5XI28
      UniProtKB/TrEMBL
      A6JNN8
      Related
      ENSRNOP00000048510.3, ENSRNOT00000046983.4
      Conserved Domains (3) summary
      cd12663
      Location:59 → 129
      RRM1_RAVER1; RNA recognition motif 1 in vertebrate ribonucleoprotein PTB-binding 1 (raver-1)
      cd12667
      Location:219 → 306
      RRM3_RAVER1; RNA recognition motif 3 in vertebrate ribonucleoprotein PTB-binding 1 (raver-1)
      cl17169
      Location:133 → 209
      RRM_SF; RNA recognition motif (RRM) superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      27886641..27907192 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039080982.2 → XP_038936910.1  ribonucleoprotein PTB-binding 1 isoform X3

    2. XM_063265041.1 → XP_063121111.1  ribonucleoprotein PTB-binding 1 isoform X2

    3. XM_063265040.1 → XP_063121110.1  ribonucleoprotein PTB-binding 1 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XI28.1 GenPept UniProtKB/Swiss-Prot:Q5XI28

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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