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    Atp9b ATPase phospholipid transporting 9B (putative) [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291411, updated on 2-May-2024

    Summary

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    Official Symbol
    Atp9bprovided by RGD
    Official Full Name
    ATPase phospholipid transporting 9B (putative)provided by RGD
    Primary source
    RGD:1563006
    See related
    Ensembl:ENSRNOG00000032039 AllianceGenome:RGD:1563006
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ATPase-coupled intramembrane lipid transporter activity. Predicted to be involved in endocytosis; phospholipid translocation; and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in endosome; plasma membrane; and trans-Golgi network. Orthologous to human ATP9B (ATPase phospholipid transporting 9B (putative)). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 112.9), Testes (RPKM 112.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Atp9b in Genome Data Viewer
    Location:
    18q12.3
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (76451821..76643931, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (74176863..74368993, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (77343551..77535608, complement)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482963 Neighboring gene CTD phosphatase subunit 1 Neighboring gene nuclear factor of activated T-cells 1 Neighboring gene uncharacterized LOC134482965 Neighboring gene uncharacterized LOC108348827 Neighboring gene spalt-like transcription factor 3 Neighboring gene uncharacterized LOC102548287

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. ATP9B, a P4-ATPase (a putative aminophospholipid translocase), localizes to the trans-Golgi network in a CDC50 protein-independent manner. Takatsu H, et al. J Biol Chem, 2011 Nov 4. PMID 21914794, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled intramembrane lipid transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATPase-coupled intramembrane lipid transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid translocation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in trans-Golgi network IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    probable phospholipid-transporting ATPase IIB
    Names
    ATPase, class II, type 9B
    NP_001099600.1
    XP_006255045.1
    XP_017456363.1
    XP_017456364.1
    XP_038952557.1
    XP_038952558.1
    XP_038952560.1
    XP_063133228.1
    XP_063133229.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106130.1 → NP_001099600.1  probable phospholipid-transporting ATPase IIB

      See identical proteins and their annotated locations for NP_001099600.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474021
      UniProtKB/Swiss-Prot
      D4ABB8
      UniProtKB/TrEMBL
      A6K5I3
      Related
      ENSRNOP00000040756.3, ENSRNOT00000041380.5
      Conserved Domains (2) summary
      cd07541
      Location:132 → 1056
      P-type_ATPase_APLT_Neo1-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Neo1p and human putative APLT, ATP9B
      pfam13246
      Location:549 → 660
      Cation_ATPase; Cation transport ATPase (P-type)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      76451821..76643931 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006254983.4 → XP_006255045.1  probable phospholipid-transporting ATPase IIB isoform X4

      See identical proteins and their annotated locations for XP_006255045.1

      UniProtKB/TrEMBL
      A0A0G2K3M6, A6K5I3, A6K5I4
      Related
      ENSRNOP00000072701.2
      Conserved Domains (6) summary
      cd01427
      Location:741 → 891
      HAD_like; Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others, ...
      TIGR01652
      Location:131 → 1134
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
      pfam00122
      Location:188 → 426
      E1-E2_ATPase; E1-E2 ATPase
      pfam13246
      Location:578 → 660
      Cation_ATPase; Cation transport ATPase (P-type)
      pfam16209
      Location:124 → 181
      PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
      pfam16212
      Location:900 → 1128
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal

    2. XM_017600875.3 → XP_017456364.1  probable phospholipid-transporting ATPase IIB isoform X2

      UniProtKB/TrEMBL
      A6K5I3

    3. XM_017600874.3 → XP_017456363.1  probable phospholipid-transporting ATPase IIB isoform X1

      UniProtKB/TrEMBL
      A0A8I6GL76, A6K5I3
      Related
      ENSRNOP00000094514.1

    4. XM_063277158.1 → XP_063133228.1  probable phospholipid-transporting ATPase IIB isoform X3

    5. XM_039096630.2 → XP_038952558.1  probable phospholipid-transporting ATPase IIB isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZJ47
      Conserved Domains (2) summary
      pfam13246
      Location:311 → 422
      Cation_ATPase; Cation transport ATPase (P-type)
      cl21460
      Location:1 → 818
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    6. XM_039096632.2 → XP_038952560.1  probable phospholipid-transporting ATPase IIB isoform X6

      UniProtKB/TrEMBL
      A6K5I2
      Conserved Domains (2) summary
      pfam13246
      Location:166 → 277
      Cation_ATPase; Cation transport ATPase (P-type)
      cl21460
      Location:1 → 673
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    7. XM_063277159.1 → XP_063133229.1  probable phospholipid-transporting ATPase IIB isoform X7

    8. XM_039096629.2 → XP_038952557.1  probable phospholipid-transporting ATPase IIB isoform X3

      UniProtKB/TrEMBL
      A6K5I3
      Conserved Domains (2) summary
      cd07541
      Location:132 → 1015
      P-type_ATPase_APLT_Neo1-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Neo1p and human putative APLT, ATP9B
      pfam13246
      Location:560 → 671
      Cation_ATPase; Cation transport ATPase (P-type)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D4ABB8.1 GenPept UniProtKB/Swiss-Prot:D4ABB8

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