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    SULT1E1 sulfotransferase family 1E member 1 [ Homo sapiens (human) ]

    Gene ID: 6783, updated on 5-Mar-2024

    Summary

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    Official Symbol
    SULT1E1provided by HGNC
    Official Full Name
    sulfotransferase family 1E member 1provided by HGNC
    Primary source
    HGNC:HGNC:11377
    See related
    Ensembl:ENSG00000109193 MIM:600043; AllianceGenome:HGNC:11377
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EST; STE; EST-1; ST1E1
    Summary
    Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a protein that transfers a sulfo moiety to and from estrone, which may control levels of estrogen receptors. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in small intestine (RPKM 11.9), duodenum (RPKM 11.7) and 4 other tissues See more
    Orthologs
    all
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    Genomic context

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    See SULT1E1 in Genome Data Viewer
    Location:
    4q13.3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (69821122..69860145, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (73176039..73194989, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (70706930..70725863, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene sulfotransferase family 1B member 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:70608551-70609050 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:70609253-70609754 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:70609755-70610254 Neighboring gene sulfotransferase family 1D member 1, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21599 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15467 Neighboring gene Sharpr-MPRA regulatory region 10246 Neighboring gene casein alpha s1 Neighboring gene casein beta

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Interaction of Native- and Oxidized-Low-Density Lipoprotein with Human Estrogen Sulfotransferase. Sato A, et al. Protein J, 2021 Apr. PMID 33665770
    2. Impact of Human SULT1E1 Polymorphisms on the Sulfation of 17β-Estradiol, 4-Hydroxytamoxifen, and Diethylstilbestrol by SULT1E1 Allozymes. El Daibani AA, et al. Eur J Drug Metab Pharmacokinet, 2021 Jan. PMID 33064293, Free PMC Article
    3. Inherited Variants in SULT1E1 and Response to Abiraterone Acetate by Men with Metastatic Castration Refractory Prostate Cancer. Agarwal N, et al. J Urol, 2016 Oct. PMID 27150425
    4. In Silico Prediction of Human Sulfotransferase 1E1 Activity Guided by Pharmacophores from Molecular Dynamics Simulations. Rakers C, et al. J Biol Chem, 2016 Jan 1. PMID 26542807, Free PMC Article
    5. New diterpenoids with estrogen sulfotransferase inhibitory activity from Leonurus sibiricus L. Narukawa Y, et al. J Nat Med, 2014 Jan. PMID 23736977

    See all (82) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Estrogen Sulfotransferase SULT1E1 Expression Levels and Regulated Factors in Malignant Tumours.
      Title: Estrogen Sulfotransferase SULT1E1 Expression Levels and Regulated Factors in Malignant Tumours.
    2. Estrogen Sulfotransferase is Highly Expressed in Vascular Endothelial Cells Overlying Atherosclerotic Plaques.
      Title: Estrogen Sulfotransferase is Highly Expressed in Vascular Endothelial Cells Overlying Atherosclerotic Plaques.
    3. Interaction of Native- and Oxidized-Low-Density Lipoprotein with Human Estrogen Sulfotransferase.
      Title: Interaction of Native- and Oxidized-Low-Density Lipoprotein with Human Estrogen Sulfotransferase.
    4. Impact of Human SULT1E1 Polymorphisms on the Sulfation of 17beta-Estradiol, 4-Hydroxytamoxifen, and Diethylstilbestrol by SULT1E1 Allozymes.
      Title: Impact of Human SULT1E1 Polymorphisms on the Sulfation of 17β-Estradiol, 4-Hydroxytamoxifen, and Diethylstilbestrol by SULT1E1 Allozymes.
    5. CYP19A1 mRNA levels were lower in endometrial cancer (EC) than in controls. A novel highly sensitive and accurate protocol to assess SULT1E1 activity is presented. STS enzyme activity and the STS:SULT1E1 activity ratio seem to be lower in ECs than in controls. STS is an important route for estrogen supply in endometrial cells.
      Title: The sulfatase pathway as estrogen supply in endometrial cancer.
    6. Increased expression of SULT1E1 is associated with obstructive cholestasis.
      Title: Cholestasis-induced bile acid elevates estrogen level via farnesoid X receptor-mediated suppression of the estrogen sulfotransferase SULT1E1.
    7. Galeterone and abiraterone are novel inhibitors of DHEA sulfonation, as determined in enzymatic incubations containing human tissue cytosol (liver or intestinal) or human recombinant SULT enzyme (SULT2A1, SULT2B1b, or SULT1E1).
      Title: Identification of Galeterone and Abiraterone as Inhibitors of Dehydroepiandrosterone Sulfonation Catalyzed by Human Hepatic Cytosol, SULT2A1, SULT2B1b, and SULT1E1.
    8. Single nucleotide polymorphisms in SULT1E1 were significantly associated with time to treatment failure in men on abiraterone acetate therapy. The single nucleotide polymorphisms may serve as predictive markers for treatment with abiraterone acetate.
      Title: Inherited Variants in SULT1E1 and Response to Abiraterone Acetate by Men with Metastatic Castration Refractory Prostate Cancer.
    9. Resveratrol and all its derivatives reduced also SULT1E1 mRNA transcript level. The reduced expression of AhR, CYP1A1, and 1B1 was also found as a result of treatment with these compounds.
      Title: Resveratrol and its methoxy derivatives modulate the expression of estrogen metabolism enzymes in breast epithelial cells by AhR down-regulation.
    10. Data show that both estrogen sulfatase (STS) and estrogen sulfotransferase (EST) were highly expressed in the human umbilical vein
      Title: Melatonin affects the dynamic steady-state equilibrium of estrogen sulfates in human umbilical vein endothelial cells by regulating the balance between estrogen sulfatase and sulfotransferase.
    Submit: New GeneRIF Correction See all GeneRIFs (49)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC34459

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables aryl sulfotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables estrone sulfotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables flavonol 3-sulfotransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables steroid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables steroid sulfotransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sulfotransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in 3'-phosphoadenosine 5'-phosphosulfate metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in estrogen catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in estrogen metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ethanol catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in steroid metabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in sulfation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within sulfation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sulfation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in nuclear membrane IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    sulfotransferase 1E1
    Names
    estrogen sulfotransferase
    estrone sulfotransferase
    sulfotransferase family 1E, estrogen-preferring, member 1
    sulfotransferase, estrogen-preferring
    NP_005411.1
    XP_011530512.1
    XP_047272056.1
    XP_047272057.1
    XP_054206726.1
    XP_054206727.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005420.3 → NP_005411.1  sulfotransferase 1E1

      See identical proteins and their annotated locations for NP_005411.1

      Status: REVIEWED

      Source sequence(s)
      AC108941
      Consensus CDS
      CCDS3531.1
      UniProtKB/Swiss-Prot
      P49888, Q8N6X5
      UniProtKB/TrEMBL
      Q53X91
      Related
      ENSP00000226444.3, ENST00000226444.4
      Conserved Domains (1) summary
      pfam00685
      Location:37 → 287
      Sulfotransfer_1; Sulfotransferase domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      69821122..69860145 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047416101.1 → XP_047272057.1  sulfotransferase 1E1 isoform X1

      UniProtKB/Swiss-Prot
      P49888, Q8N6X5
      UniProtKB/TrEMBL
      Q53X91

    2. XM_047416100.1 → XP_047272056.1  sulfotransferase 1E1 isoform X1

      UniProtKB/Swiss-Prot
      P49888, Q8N6X5
      UniProtKB/TrEMBL
      Q53X91

    3. XM_011532210.3 → XP_011530512.1  sulfotransferase 1E1 isoform X2

      Conserved Domains (1) summary
      pfam00685
      Location:37 → 165
      Sulfotransfer_1; Sulfotransferase domain

    RNA

    1. XR_007057952.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      73176039..73194989 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054350751.1 → XP_054206726.1  sulfotransferase 1E1 isoform X1

      UniProtKB/Swiss-Prot
      P49888, Q8N6X5
      UniProtKB/TrEMBL
      Q53X91

    2. XM_054350752.1 → XP_054206727.1  sulfotransferase 1E1 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P49888.1 GenPept UniProtKB/Swiss-Prot:P49888

    Gene LinkOut

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