Cckar cholecystokinin A receptor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cckarprovided by MGI
Official Full Name: cholecystokinin A receptorprovided by MGI
Primary source: MGI:MGI:99478
See related: Ensembl:ENSMUSG00000029193 AllianceGenome:MGI:99478
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable cholecystokinin receptor activity and peptide hormone binding activity. Acts upstream of or within axonogenesis; forebrain development; and neuron migration. Predicted to be located in several cellular components, including endosome; lysosome; and terminal bouton. Predicted to be integral component of plasma membrane. Is expressed in several structures, including brain; genitourinary system; gut; and respiratory system. Human ortholog(s) of this gene implicated in obesity. Orthologous to human CCKAR (cholecystokinin A receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in lung adult (RPKM 14.7), kidney adult (RPKM 12.1) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 C1; 5 29.52 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (53855827..53865046, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (53698485..53707704, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cholecystokinin Activation of Cholecystokinin 1 Receptors: a Purkinje Cell Neuroprotective Pathway.
Title: Cholecystokinin Activation of Cholecystokinin 1 Receptors: a Purkinje Cell Neuroprotective Pathway.
The studies establish chronic pancreatitis as an IL-33-dependent inflammation resulting from synergistic interactions between the NOD1 and CCKR signaling pathways.
Title: Nucleotide-binding oligomerization domain 1 acts in concert with the cholecystokinin receptor agonist, cerulein, to induce IL-33-dependent chronic pancreatitis.
There is functional synergy between cholecystokinin receptors CCKAR and CCKBR in mammalian brain development.
Title: Functional synergy between cholecystokinin receptors CCKAR and CCKBR in mammalian brain development.
mice lacking CCK receptors exhibited a functional shift from the gastrin-CCK pathways to the neuronal pathway in control of the ECL cells and eventually the acid secretion
Title: Gene expression profiling of gastric mucosa in mice lacking CCK and gastrin receptors.
cellular and subcellular localization of cholecystokinin (CCK)-1 receptors in the pancreas, gallbladder, and stomach
Title: Cellular and subcellular localization of cholecystokinin (CCK)-1 receptors in the pancreas, gallbladder, and stomach of mice.
The lithogenic diet was associated with significantly lower CAV3 in the liver and lower CAV3 and CCKAR in the gallbladder compared with the control mice.
Title: Association of caveolin-3 and cholecystokinin A receptor with cholesterol gallstone disease in mice.
CCK-8S increases [Ca(2+)]i in gastric antral interstitial cells of Cajal via the CCK(1) receptor
Title: Mechanisms of cholecystokinin-induced calcium mobilization in gastric antral interstitial cells of Cajal.
CCK1 receptor activation does not have a greater effect combination with upregulated leptin signalling in high-fat-fed mice
Title: Comparison of the metabolic effects of sustained CCK1 receptor activation alone and in combination with upregulated leptin signalling in high-fat-fed mice.
Suggest role for ependymal CCK-1 receptors in infant satiety-controlling mechanisms.
Title: Infant satiety depends on transient expression of cholecystokinin-1 receptors on ependymal cells lining the third ventricle in mice.
CCK-1 and -2 receptors may function synergistically in single PaPo neurons and deletion of CCK-1 receptors may facilitate CCK-2 receptor signaling.
Title: Functional compensation between cholecystokinin-1 and -2 receptors in murine paraventricular nucleus neurons.

Submit: New GeneRIF Correction See all GeneRIFs (29)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation
Targeted (4) 1 citation

General gene information

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Markers

PMC129753P2 (e-PCR)
- UniSTS:270600

AF015963 (e-PCR)
- UniSTS:163360

Cckar (e-PCR), detects polymorphism
- UniSTS:265052

Cckar (e-PCR), detects polymorphism
- UniSTS:525206

AW106902 (e-PCR)
- UniSTS:179164

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables cholecystokinin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables cholecystokinin receptor activity	ISO Inferred from Sequence Orthology more info
enables peptide binding	IBA Inferred from Biological aspect of Ancestor more info
enables peptide hormone binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to hormone stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in cholecystokinin signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in eating behavior	ISO Inferred from Sequence Orthology more info
involved_in feeding behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within forebrain development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gastric acid secretion	ISO Inferred from Sequence Orthology more info
involved_in insulin secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of somatostatin secretion	ISO Inferred from Sequence Orthology more info
involved_in reduction of food intake in response to dietary excess	ISO Inferred from Sequence Orthology more info
involved_in regulation of calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of hormone secretion	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of potassium ion transport	ISO Inferred from Sequence Orthology more info
involved_in response to starvation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
involved_in temperature homeostasis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in terminal bouton	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cholecystokinin receptor type A

Names: CCK-A receptor; CCK-AR; CCK1-R; cholecystokinin-1 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001347354.1 → NP_001334283.1 cholecystokinin receptor type A isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.

Source sequence(s)

AC084054, AC122196

Consensus CDS

CCDS84881.1

UniProtKB/TrEMBL

Q3TPL0

Related

ENSMUSP00000144103.2, ENSMUST00000200691.4
NM_009827.2 → NP_033957.1 cholecystokinin receptor type A isoform 1

See identical proteins and their annotated locations for NP_033957.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AK004730, AK147052

Consensus CDS

CCDS19293.1

UniProtKB/Swiss-Prot

O08786, Q8VCC7, Q9DBV6

Related

ENSMUSP00000031093.4, ENSMUST00000031093.5

Conserved Domains (3) summary

pfam00001
Location:58 → 378

7tm_1; 7 transmembrane receptor (rhodopsin family)

pfam09193
Location:1 → 47

CholecysA-Rec_N; Cholecystokinin A receptor, N-terminal

cl21561
Location:48 → 196

7tm_4; Olfactory receptor