Ifit2 interferon-induced protein with tetratricopeptide repeats 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ifit2provided by RGD
Official Full Name: interferon-induced protein with tetratricopeptide repeats 2provided by RGD
Primary source: RGD:1307804
See related: Ensembl:ENSRNOG00000036604 AllianceGenome:RGD:1307804
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable RNA binding activity. Predicted to be involved in defense response to virus; negative regulation of protein binding activity; and positive regulation of apoptotic process. Predicted to act upstream of or within cellular response to interferon-alpha. Predicted to be located in endoplasmic reticulum. Predicted to be active in cytosol. Orthologous to human IFIT2 (interferon induced protein with tetratricopeptide repeats 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 87.7), Lung (RPKM 87.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q53

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (241515735..241521799)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (232102570..232108638)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (252894663..252900727)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AU026235 (e-PCR)
- UniSTS:114480

AI009765 (e-PCR)
- UniSTS:249946

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
acts_upstream_of_or_within antiviral innate immune response	ISO Inferred from Sequence Orthology more info
involved_in antiviral innate immune response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to interferon-alpha	ISO Inferred from Sequence Orthology more info
involved_in defense response to virus	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in response to virus	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: interferon-induced protein with tetratricopeptide repeats 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001024753.1 → NP_001019924.1 interferon-induced protein with tetratricopeptide repeats 2

See identical proteins and their annotated locations for NP_001019924.1

Status: PROVISIONAL

Source sequence(s)

BC097384

UniProtKB/TrEMBL

A6I135, Q4V8H9

Related

ENSRNOP00000051639.2, ENSRNOT00000054757.4

Conserved Domains (2) summary

sd00006
Location:242 → 270

TPR; TPR repeat [structural motif]

pfam13424
Location:51 → 126

TPR_12; Tetratricopeptide repeat