Clasp2 cytoplasmic linker associated protein 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Clasp2provided by RGD
Official Full Name: cytoplasmic linker associated protein 2provided by RGD
Primary source: RGD:619789
See related: Ensembl:ENSRNOG00000009161 AllianceGenome:RGD:619789
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables microtubule binding activity. Involved in cellular response to insulin stimulus; negative regulation of microtubule depolymerization; and positive regulation of protein localization to membrane. Located in microtubule and ruffle membrane. Orthologous to human CLASP2 (cytoplasmic linker associated protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 402.6), Adrenal (RPKM 146.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q32

Exon count:: 45

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (122555532..122736934)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (113677345..113859957)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (122003719..122185495)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

KIF1C translocation to the cell periphery intensifies and KIF1C accumulates both in the proximity of peripheral microtubules that show enrichment for the plus-tip-associated proteins CLASPs and around podosomes.
Title: Podosome-regulating kinesin KIF1C translocates to the cell periphery in a CLASP-dependent manner.
GSK3beta may play an essential role in the electric field-induced cell polarization via CLASP2 regulation and beta-catenin coordination
Title: Electric signals regulate directional migration of ventral midbrain derived dopaminergic neural progenitor cells via Wnt/GSK3β signaling.
CLASP2 directs the delivery of GLUT4 to cell cortex landing zones important for insulin action
Title: Identification of a role for CLASP2 in insulin action.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BF390126 (e-PCR)
- UniSTS:249390

BF397826 (e-PCR)
- UniSTS:246332

BF390322 (e-PCR)
- UniSTS:249440

BF404140 (e-PCR)
- UniSTS:246926

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin filament binding	ISO Inferred from Sequence Orthology more info
enables dystroglycan binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IDA Inferred from Direct Assay more info	PubMed
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables microtubule plus-end binding	ISO Inferred from Sequence Orthology more info
enables microtubule plus-end binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein tyrosine kinase binding	ISO Inferred from Sequence Orthology more info
enables tubulin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Golgi organization	ISO Inferred from Sequence Orthology more info
involved_in Golgi organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in cellular response to insulin stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in establishment of cell polarity	ISO Inferred from Sequence Orthology more info
involved_in establishment of mitotic spindle localization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within establishment or maintenance of cell polarity	ISO Inferred from Sequence Orthology more info
involved_in exit from mitosis	ISO Inferred from Sequence Orthology more info
involved_in exit from mitosis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within fibroblast migration	ISO Inferred from Sequence Orthology more info
involved_in microtubule anchoring	ISO Inferred from Sequence Orthology more info
involved_in microtubule anchoring	ISS Inferred from Sequence or Structural Similarity more info
involved_in microtubule cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in microtubule cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of microtubule depolymerization	ISO Inferred from Sequence Orthology more info
involved_in microtubule nucleation	ISO Inferred from Sequence Orthology more info
involved_in microtubule nucleation	ISS Inferred from Sequence or Structural Similarity more info
involved_in microtubule organizing center organization	ISO Inferred from Sequence Orthology more info
involved_in microtubule organizing center organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitotic spindle assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic spindle organization	ISO Inferred from Sequence Orthology more info
involved_in mitotic spindle organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of focal adhesion assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of microtubule depolymerization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of microtubule depolymerization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of stress fiber assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of supramolecular fiber organization	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of wound healing, spreading of epidermal cells	ISO Inferred from Sequence Orthology more info
involved_in platelet-derived growth factor receptor-beta signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of basement membrane assembly involved in embryonic body morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of exocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of extracellular matrix disassembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in presynaptic cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of axon extension	ISO Inferred from Sequence Orthology more info
involved_in regulation of epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in regulation of gastrulation	ISO Inferred from Sequence Orthology more info
involved_in regulation of microtubule polymerization	ISO Inferred from Sequence Orthology more info
involved_in regulation of microtubule polymerization or depolymerization	IEA Inferred from Electronic Annotation more info
involved_in regulation of microtubule polymerization or depolymerization	ISO Inferred from Sequence Orthology more info
involved_in regulation of microtubule-based process	ISO Inferred from Sequence Orthology more info
involved_in regulation of microtubule-based process	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of supramolecular fiber organization	IEA Inferred from Electronic Annotation more info
involved_in vesicle targeting	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
located_in axonal growth cone	ISO Inferred from Sequence Orthology more info
is_active_in basal cortex	IBA Inferred from Biological aspect of Ancestor more info
located_in basal cortex	ISO Inferred from Sequence Orthology more info
located_in cell cortex	ISO Inferred from Sequence Orthology more info
located_in cell leading edge	ISO Inferred from Sequence Orthology more info
located_in cell leading edge	ISS Inferred from Sequence or Structural Similarity more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in cortical microtubule plus-end	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasmic microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic microtubule	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic microtubule	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in kinetochore	IBA Inferred from Biological aspect of Ancestor more info
located_in kinetochore	IEA Inferred from Electronic Annotation more info
located_in kinetochore	ISO Inferred from Sequence Orthology more info
located_in kinetochore	ISS Inferred from Sequence or Structural Similarity more info
located_in microtubule	IDA Inferred from Direct Assay more info	PubMed
located_in microtubule	ISO Inferred from Sequence Orthology more info
located_in microtubule cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
is_active_in microtubule organizing center	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitotic spindle	IBA Inferred from Biological aspect of Ancestor more info
located_in mitotic spindle	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in ruffle membrane	IDA Inferred from Direct Assay more info	PubMed
located_in ruffle membrane	ISO Inferred from Sequence Orthology more info
located_in ruffle membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in spindle microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: CLIP-associating protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053722.2 → NP_446174.1 CLIP-associating protein 2

See identical proteins and their annotated locations for NP_446174.1

Status: VALIDATED

Source sequence(s)

AJ288060, CX570719, DY568613

UniProtKB/Swiss-Prot

Q99JD4

UniProtKB/TrEMBL

A0A8I6GL90, A6I3M4

Related

ENSRNOP00000095678.1, ENSRNOT00000100370.1

Conserved Domains (2) summary

sd00044
Location:648 → 675

HEAT; HEAT repeat [structural motif]

pfam12348
Location:99 → 311

CLASP_N; CLASP N terminal

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

122555532..122736934

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063264756.1 → XP_063120826.1 CLIP-associating protein 2 isoform X32

UniProtKB/TrEMBL

A0A8I6AMK8
XM_063264733.1 → XP_063120803.1 CLIP-associating protein 2 isoform X1
XM_039080674.2 → XP_038936602.1 CLIP-associating protein 2 isoform X6

UniProtKB/TrEMBL

A0A8I5ZKF9

Conserved Domains (3) summary

sd00044
Location:91 → 121

HEAT; HEAT repeat [structural motif]

pfam15402
Location:687 → 809

Spc7_N; N-terminus of kinetochore NMS complex subunit Spc7

pfam12348
Location:326 → 538

CLASP_N; CLASP N terminal
XM_063264735.1 → XP_063120805.1 CLIP-associating protein 2 isoform X3
XM_039080677.2 → XP_038936605.1 CLIP-associating protein 2 isoform X10

UniProtKB/TrEMBL

A0A8I5ZKF9

Conserved Domains (3) summary

PHA03307
Location:570 → 824

PHA03307; transcriptional regulator ICP4; Provisional

sd00044
Location:91 → 121

HEAT; HEAT repeat [structural motif]

pfam12348
Location:326 → 538

CLASP_N; CLASP N terminal
XM_063264739.1 → XP_063120809.1 CLIP-associating protein 2 isoform X8
XM_063264745.1 → XP_063120815.1 CLIP-associating protein 2 isoform X16
XM_063264743.1 → XP_063120813.1 CLIP-associating protein 2 isoform X13
XM_063264747.1 → XP_063120817.1 CLIP-associating protein 2 isoform X19
XM_063264750.1 → XP_063120820.1 CLIP-associating protein 2 isoform X24
XM_063264752.1 → XP_063120822.1 CLIP-associating protein 2 isoform X27
XM_063264736.1 → XP_063120806.1 CLIP-associating protein 2 isoform X4
XM_063264741.1 → XP_063120811.1 CLIP-associating protein 2 isoform X11
XM_063264748.1 → XP_063120818.1 CLIP-associating protein 2 isoform X20
XM_039080685.2 → XP_038936613.1 CLIP-associating protein 2 isoform X22

UniProtKB/TrEMBL

A0A8I5ZX03

Related

ENSRNOP00000071109.2

Conserved Domains (2) summary

sd00044
Location:91 → 121

HEAT; HEAT repeat [structural motif]

pfam12348
Location:326 → 538

CLASP_N; CLASP N terminal
XM_063264738.1 → XP_063120808.1 CLIP-associating protein 2 isoform X7
XM_039080680.2 → XP_038936608.1 CLIP-associating protein 2 isoform X15

UniProtKB/TrEMBL

A0A8I5ZKF9

Conserved Domains (2) summary

sd00044
Location:91 → 121

HEAT; HEAT repeat [structural motif]

pfam12348
Location:326 → 538

CLASP_N; CLASP N terminal
XM_063264742.1 → XP_063120812.1 CLIP-associating protein 2 isoform X12
XM_039080683.2 → XP_038936611.1 CLIP-associating protein 2 isoform X18

UniProtKB/TrEMBL

A0A8I5ZKF9

Conserved Domains (2) summary

sd00044
Location:91 → 121

HEAT; HEAT repeat [structural motif]

pfam12348
Location:326 → 538

CLASP_N; CLASP N terminal
XM_063264746.1 → XP_063120816.1 CLIP-associating protein 2 isoform X17
XM_039080686.2 → XP_038936614.1 CLIP-associating protein 2 isoform X23

UniProtKB/TrEMBL

A0A8I5ZKF9

Conserved Domains (2) summary

sd00044
Location:91 → 121

HEAT; HEAT repeat [structural motif]

pfam12348
Location:326 → 538

CLASP_N; CLASP N terminal
XM_063264749.1 → XP_063120819.1 CLIP-associating protein 2 isoform X21
XM_039080688.2 → XP_038936616.1 CLIP-associating protein 2 isoform X26

UniProtKB/TrEMBL

A0A8I5ZX03

Conserved Domains (2) summary

sd00044
Location:91 → 121

HEAT; HEAT repeat [structural motif]

pfam12348
Location:326 → 538

CLASP_N; CLASP N terminal
XM_063264754.1 → XP_063120824.1 CLIP-associating protein 2 isoform X29
XM_063264734.1 → XP_063120804.1 CLIP-associating protein 2 isoform X2
XM_063264740.1 → XP_063120810.1 CLIP-associating protein 2 isoform X9
XM_063264753.1 → XP_063120823.1 CLIP-associating protein 2 isoform X28
XM_063264737.1 → XP_063120807.1 CLIP-associating protein 2 isoform X5
XM_063264744.1 → XP_063120814.1 CLIP-associating protein 2 isoform X14
XM_063264771.1 → XP_063120841.1 CLIP-associating protein 2 isoform X49

UniProtKB/TrEMBL

A0A8I6AMJ1
XM_063264751.1 → XP_063120821.1 CLIP-associating protein 2 isoform X25
XM_039080691.2 → XP_038936619.1 CLIP-associating protein 2 isoform X30

UniProtKB/TrEMBL

A0A8I5ZX03

Related

ENSRNOP00000095411.1

Conserved Domains (2) summary

sd00044
Location:91 → 121

HEAT; HEAT repeat [structural motif]

pfam12348
Location:326 → 538

CLASP_N; CLASP N terminal
XM_063264755.1 → XP_063120825.1 CLIP-associating protein 2 isoform X31
XM_063264758.1 → XP_063120828.1 CLIP-associating protein 2 isoform X34
XM_063264761.1 → XP_063120831.1 CLIP-associating protein 2 isoform X37
XM_063264764.1 → XP_063120834.1 CLIP-associating protein 2 isoform X41
XM_063264768.1 → XP_063120838.1 CLIP-associating protein 2 isoform X45
XM_063264769.1 → XP_063120839.1 CLIP-associating protein 2 isoform X47
XM_063264770.1 → XP_063120840.1 CLIP-associating protein 2 isoform X48
XM_063264762.1 → XP_063120832.1 CLIP-associating protein 2 isoform X38
XM_063264757.1 → XP_063120827.1 CLIP-associating protein 2 isoform X33
XM_063264759.1 → XP_063120829.1 CLIP-associating protein 2 isoform X35
XM_017595407.3 → XP_017450896.1 CLIP-associating protein 2 isoform X39

UniProtKB/TrEMBL

A0A8I6GL90, A0A8L2UIH1

Related

ENSRNOP00000012545.5
XM_063264766.1 → XP_063120836.1 CLIP-associating protein 2 isoform X43
XM_063264767.1 → XP_063120837.1 CLIP-associating protein 2 isoform X44
XM_063264760.1 → XP_063120830.1 CLIP-associating protein 2 isoform X36
XM_063264763.1 → XP_063120833.1 CLIP-associating protein 2 isoform X40
XM_063264765.1 → XP_063120835.1 CLIP-associating protein 2 isoform X42
XM_039080695.2 → XP_038936623.1 CLIP-associating protein 2 isoform X46

UniProtKB/TrEMBL

A0A8I6GL90

Conserved Domains (2) summary

sd00044
Location:640 → 667

HEAT; HEAT repeat [structural motif]

pfam12348
Location:99 → 311

CLASP_N; CLASP N terminal