Ptges3 prostaglandin E synthase 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ptges3provided by RGD
Official Full Name: prostaglandin E synthase 3provided by RGD
Primary source: RGD:1561913
See related: Ensembl:ENSRNOG00000002642 AllianceGenome:RGD:1561913
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1561913
Summary: Enables several functions, including Hsp90 protein binding activity; p53 binding activity; and prostaglandin-E synthase activity. Involved in several processes, including negative regulation of cell death; prostaglandin biosynthetic process; and sensory perception of pain. Located in several cellular components, including actin filament; neuronal cell body; and perinuclear region of cytoplasm. Part of protein-containing complex. Orthologous to human PTGES3 (prostaglandin E synthase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 650.6), Kidney (RPKM 608.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q11

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (1075230..1092363)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (490698..507759)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (2479267..2497024)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study in cultured rat fibroblasts suggests that cPGES/p23 is involved in the activation of ERK to promote c-Fos expression.
Title: Cytosolic Prostaglandin E Synthase Is Involved in c-Fos Expression in Rat Fibroblastic 3Y1 Cells.
Cytosolic prostaglandin E2 synthase plays an important role in mediating early responses during spinal nociceptive processing.
Title: Downregulation of cytosolic prostaglandin E2 synthase results in decreased nociceptive behavior in rats.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:234880 (e-PCR)
- UniSTS:234880

RH127823 (e-PCR)
- UniSTS:211133

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA polymerase binding	IEA Inferred from Electronic Annotation more info
enables DNA polymerase binding	ISO Inferred from Sequence Orthology more info
enables Hsp90 protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables Hsp90 protein binding	IDA Inferred from Direct Assay more info	PubMed
enables Hsp90 protein binding	IEA Inferred from Electronic Annotation more info
enables Hsp90 protein binding	ISO Inferred from Sequence Orthology more info
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables isomerase activity	IEA Inferred from Electronic Annotation more info
enables p53 binding	IDA Inferred from Direct Assay more info	PubMed
enables prostaglandin-E synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables prostaglandin-E synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables prostaglandin-E synthase activity	IEA Inferred from Electronic Annotation more info
enables prostaglandin-E synthase activity	ISO Inferred from Sequence Orthology more info
enables prostaglandin-E synthase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein-folding chaperone binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein-folding chaperone binding	IEA Inferred from Electronic Annotation more info
enables telomerase activity	ISO Inferred from Sequence Orthology more info
enables unfolded protein binding	ISO Inferred from Sequence Orthology more info
enables unfolded protein binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in chaperone cofactor-dependent protein refolding	ISO Inferred from Sequence Orthology more info
involved_in chaperone-mediated protein complex assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in chaperone-mediated protein complex assembly	ISO Inferred from Sequence Orthology more info
involved_in fibroblast proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within fibroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in glycogen biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glycogen biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in intracellular glucocorticoid receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within intracellular glucocorticoid receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in lung saccule development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lung saccule development	ISO Inferred from Sequence Orthology more info
involved_in neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in prostaglandin biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in prostaglandin biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in prostaglandin biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in prostaglandin biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within prostaglandin biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in prostaglandin biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in prostaglandin biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in prostaglandin metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info
involved_in skin development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within skin development	ISO Inferred from Sequence Orthology more info
involved_in telomerase holoenzyme complex assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in telomerase holoenzyme complex assembly	IEA Inferred from Electronic Annotation more info
involved_in telomerase holoenzyme complex assembly	ISO Inferred from Sequence Orthology more info
involved_in telomere maintenance via telomerase	IBA Inferred from Biological aspect of Ancestor more info
involved_in telomere maintenance via telomerase	IEA Inferred from Electronic Annotation more info
acts_upstream_of_positive_effect telomere maintenance via telomerase	ISO Inferred from Sequence Orthology more info
involved_in telomere maintenance via telomerase	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in actin filament	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
part_of protein folding chaperone complex	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of telomerase holoenzyme complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: prostaglandin E synthase 3

Names: cPGES; cytosolic prostaglandin E2 synthase; hsp90 co-chaperone; progesterone receptor complex p23; prostaglandin E synthase 3 (cytosolic); telomerase-binding protein p23

NP_001124461.1

EC 5.3.99.3

XP_063119767.1

EC 5.3.99.3

XP_063119768.1

EC 5.3.99.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001130989.2 → NP_001124461.1 prostaglandin E synthase 3

See identical proteins and their annotated locations for NP_001124461.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000007

UniProtKB/Swiss-Prot

P83868

UniProtKB/TrEMBL

A0A8I6AQE2, B2GV92, R9PXR7

Related

ENSRNOP00000003787.8, ENSRNOT00000003787.8

Conserved Domains (1) summary

cd00237
Location:3 → 109

p23; p23 binds heat shock protein (Hsp)90 and participates in the folding of a number of Hsp90 clients, including the progesterone receptor. p23 also has a passive chaperoning activity and in addition may participate in prostaglandin synthesis.

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

1075230..1092363

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063263698.1 → XP_063119768.1 prostaglandin E synthase 3 isoform X2

UniProtKB/TrEMBL

A0A8I5ZTE4
XM_063263697.1 → XP_063119767.1 prostaglandin E synthase 3 isoform X1