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    Elmo2 engulfment and cell motility 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362271, updated on 31-Mar-2024

    Summary

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    Symbol
    Elmo2provided by RGD
    Full Name
    engulfment and cell motility 2provided by RGD
    Primary source
    RGD:1305784
    See related
    Ensembl:ENSRNOG00000018747 AllianceGenome:RGD:1305784
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable receptor tyrosine kinase binding activity. Predicted to be involved in actin filament organization and cell chemotaxis. Predicted to be located in cytosol and membrane. Orthologous to human ELMO2 (engulfment and cell motility 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 140.6), Brain (RPKM 139.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Elmo2 in Genome Data Viewer
    Location:
    3q42
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (174442965..174716723, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (154023661..154061259, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (161812474..161850006, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486204 Neighboring gene solute carrier family 35 member C2 Neighboring gene zinc finger protein 663 Neighboring gene zinc finger protein 334 Neighboring gene osteoclast stimulatory transmembrane protein Neighboring gene solute carrier family 13 member 3 Neighboring gene uncharacterized LOC134486203 Neighboring gene Tp53 tumor protein p53 regulating kinase A Neighboring gene solute carrier family 2 member 10 Neighboring gene uncharacterized LOC120101927 Neighboring gene EYA transcriptional coactivator and phosphatase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Ephexin4 and EphA2 mediate cell migration through a RhoG-dependent mechanism. Hiramoto-Yamaki N, et al. J Cell Biol, 2010 Aug 9. PMID 20679435, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC109347

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables receptor tyrosine kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phagocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    engulfment and cell motility protein 2
    Names
    engulfment and cell motility 2, ced-12 homolog
    engulfment and cell motility protein 2-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134955.3 → NP_001128427.1  engulfment and cell motility protein 2

      See identical proteins and their annotated locations for NP_001128427.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6G6K9, A6JXF0, G3V982
      Related
      ENSRNOP00000039023.3, ENSRNOT00000049262.5
      Conserved Domains (3) summary
      cd13359
      Location:551 → 680
      PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain
      pfam04727
      Location:307 → 486
      ELMO_CED12; ELMO/CED-12 family
      pfam11841
      Location:116 → 283
      DUF3361; Domain of unknown function (DUF3361)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      174442965..174716723 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063284221.1 → XP_063140291.1  engulfment and cell motility protein 2 isoform X2

    2. XM_006235599.5 → XP_006235661.1  engulfment and cell motility protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006235661.1

      UniProtKB/TrEMBL
      A0A8I6G6K9, A6JXE9
      Related
      ENSRNOP00000096486.1
      Conserved Domains (3) summary
      cd13359
      Location:539 → 668
      PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain
      pfam04727
      Location:297 → 469
      ELMO_CED12; ELMO/CED-12 family
      pfam11841
      Location:115 → 271
      DUF3361; Domain of unknown function (DUF3361)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001013208.1: Suppressed sequence

      Description
      NM_001013208.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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