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    Bri3 brain protein I3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304284, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Bri3provided by RGD
    Official Full Name
    brain protein I3provided by RGD
    Primary source
    RGD:1309187
    See related
    Ensembl:ENSRNOG00000001009 AllianceGenome:RGD:1309187
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable identical protein binding activity. Predicted to be located in lysosomal membrane and perinuclear region of cytoplasm. Predicted to be integral component of membrane. Orthologous to human BRI3 (brain protein I3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 246.9), Heart (RPKM 167.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Bri3 in Genome Data Viewer
    Location:
    12p11
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (15454673..15478319, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (10341007..10364655, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (12322247..12330929, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene U4 spliceosomal RNA Neighboring gene BAR/IMD domain containing adaptor protein 2 like 1 Neighboring gene ubiquitin-conjugating enzyme E2N, pseudogene 5 Neighboring gene uncharacterized LOC102554669 Neighboring gene tectonin beta-propeller repeat containing 1 Neighboring gene basic helix-loop-helix family, member a15 Neighboring gene lemur tyrosine kinase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. MicroRNA-323 regulates ischemia/reperfusion injury-induced neuronal cell death by targeting BRI3. Yang L, et al. Int J Clin Exp Pathol, 2015. PMID 26617783, Free PMC Article
    2. Beta-amyloid protein converting enzyme 1 and brain-specific type II membrane protein BRI3: binding partners processed by furin. Wickham L, et al. J Neurochem, 2005 Jan. PMID 15606899
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. miR-323 might regulate ischemia/reperfusion-induced rat neuronal cell death via targeting BRI3.
      Title: MicroRNA-323 regulates ischemia/reperfusion injury-induced neuronal cell death by targeting BRI3.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC105711

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    membrane protein BRI3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009604.2 → NP_001009604.1  membrane protein BRI3 isoform 1

      See identical proteins and their annotated locations for NP_001009604.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/Swiss-Prot
      Q5PPK1
      Related
      ENSRNOP00000001336.4, ENSRNOT00000001336.7
      Conserved Domains (1) summary
      pfam10164
      Location:29 → 124
      DUF2367; Uncharacterized conserved protein (DUF2367)

    2. NM_001393811.1 → NP_001380740.1  membrane protein BRI3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      A0A8I6AW69
      Related
      ENSRNOP00000092853.1, ENSRNOT00000092487.2
      Conserved Domains (1) summary
      pfam10164
      Location:34 → 119
      DUF2367; Uncharacterized conserved protein (DUF2367)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      15454673..15478319 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5PPK1.1 GenPept UniProtKB/Swiss-Prot:Q5PPK1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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