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    Trappc4 trafficking protein particle complex subunit 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 367073, updated on 25-Apr-2024

    Summary

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    Official Symbol
    Trappc4provided by RGD
    Official Full Name
    trafficking protein particle complex subunit 4provided by RGD
    Primary source
    RGD:1302991
    See related
    Ensembl:ENSRNOG00000011904 AllianceGenome:RGD:1302991
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Sbdn
    Summary
    Predicted to be involved in autophagy; dendrite development; and endoplasmic reticulum to Golgi vesicle-mediated transport. Predicted to be located in Golgi stack; dendrite; and synaptic vesicle. Predicted to be part of TRAPP complex. Orthologous to human TRAPPC4 (trafficking protein particle complex subunit 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 90.9), Brain (RPKM 86.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Trappc4 in Genome Data Viewer
    Location:
    8q22
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (53626382..53630042, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (44729458..44733285, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (48723755..48727182, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene hypoxia up-regulated 1 Neighboring gene solute carrier family 37 member 4 Neighboring gene ribosomal protein s25 Neighboring gene centrosomal AT-AC splicing factor Neighboring gene methyltransferase like 9, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Deficiencies in vesicular transport mediated by TRAPPC4 are associated with severe syndromic intellectual disability. Van Bergen NJ, et al. Brain, 2020 Jan 1. PMID 31794024, Free PMC Article
    2. Synbindin, A novel syndecan-2-binding protein in neuronal dendritic spines. Ethell IM, et al. J Cell Biol, 2000 Oct 2. PMID 11018053, Free PMC Article
    3. mBET3 is required for the organization of the TRAPP complexes. Menon S, et al. Biochem Biophys Res Commun, 2006 Nov 24. PMID 17027922
    4. C4orf41 and TTC-15 are mammalian TRAPP components with a role at an early stage in ER-to-Golgi trafficking. Scrivens PJ, et al. Mol Biol Cell, 2011 Jun 15. PMID 21525244, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in autophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in autophagy ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in dendrite development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in dendrite development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi stack IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi stack ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of TRAPP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of TRAPP complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of TRAPP complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of TRAPP complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in postsynaptic density membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in presynaptic active zone ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synaptic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    trafficking protein particle complex subunit 4
    Names
    synbindin
    trafficking protein particle complex 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003708.1 → NP_001003708.1  trafficking protein particle complex subunit 4

      See identical proteins and their annotated locations for NP_001003708.1

      Status: PROVISIONAL

      Source sequence(s)
      AY373378
      UniProtKB/Swiss-Prot
      Q4G098, Q69BT7
      UniProtKB/TrEMBL
      A0A8I6A204
      Related
      ENSRNOP00000016145.3, ENSRNOT00000016145.7
      Conserved Domains (1) summary
      pfam04099
      Location:3 → 209
      Sybindin; Sybindin-like family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      53626382..53630042 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039081858.2 → XP_038937786.1  trafficking protein particle complex subunit 4 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A204, A0A8I6GKF4, A6J3Y3
      Related
      ENSRNOP00000093760.1
      Conserved Domains (1) summary
      cd14856
      Location:4 → 193
      TRAPPC4_synbindin; Trafficking protein particle complex subunit 4

    2. XM_039081859.2 → XP_038937787.1  trafficking protein particle complex subunit 4 isoform X2

      Conserved Domains (1) summary
      cl38905
      Location:45 → 99
      longin-like; Longin-like domains
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q69BT7.1 GenPept UniProtKB/Swiss-Prot:Q69BT7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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