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    Haus8 HAUS augmin-like complex, subunit 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 290626, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Haus8provided by RGD
    Official Full Name
    HAUS augmin-like complex, subunit 8provided by RGD
    Primary source
    RGD:1311565
    See related
    Ensembl:ENSRNOG00000052038 AllianceGenome:RGD:1311565
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ny-sar-48; RGD1311565
    Summary
    Predicted to enable microtubule binding activity. Predicted to be involved in centrosome cycle and spindle assembly. Predicted to be located in mitotic spindle microtubule. Predicted to be part of HAUS complex. Predicted to be active in centrosome; cytoplasm; and nuclear microtubule. Orthologous to human HAUS8 (HAUS augmin like complex subunit 8). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 100.9), Spleen (RPKM 95.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Haus8 in Genome Data Viewer
    Location:
    16p14
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (17964813..17979313, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (17930819..17945254, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (19654785..19669221, complement)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482464 Neighboring gene zinc finger protein 878 Neighboring gene zinc finger protein 709 Neighboring gene myosin IXb Neighboring gene unconventional SNARE in the ER 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. HAUS, the 8-subunit human Augmin complex, regulates centrosome and spindle integrity. Lawo S, et al. Curr Biol, 2009 May 26. PMID 19427217
    2. The augmin complex plays a critical role in spindle microtubule generation for mitotic progression and cytokinesis in human cells. Uehara R, et al. Proc Natl Acad Sci U S A, 2009 Apr 28. PMID 19369198, Free PMC Article
    3. Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. Jakobsen L, et al. EMBO J, 2011 Apr 20. PMID 21399614, Free PMC Article
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC108884

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in centrosome cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in centrosome cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in centrosome cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spindle assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spindle assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of HAUS complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of HAUS complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitotic spindle microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitotic spindle microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nuclear microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in spindle pole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    HAUS augmin-like complex subunit 8
    Names
    HEC1/NDC80-interacting centrosome-associated protein 1
    sarcoma antigen NY-SAR-48 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024971.2 → NP_001020142.2  HAUS augmin-like complex subunit 8

      See identical proteins and their annotated locations for NP_001020142.2

      Status: VALIDATED

      Source sequence(s)
      BF412974, BQ207735, CB691625, DY317896
      UniProtKB/Swiss-Prot
      Q5BK57
      UniProtKB/TrEMBL
      A6K9R7
      Conserved Domains (1) summary
      TIGR02168
      Location:135 → 346
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      17964813..17979313 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008771077.4 → XP_008769299.1  HAUS augmin-like complex subunit 8 isoform X4

      UniProtKB/TrEMBL
      A6K9R7
      Conserved Domains (1) summary
      TIGR02168
      Location:134 → 319
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    2. XM_039094283.2 → XP_038950211.1  HAUS augmin-like complex subunit 8 isoform X2

      UniProtKB/TrEMBL
      A6K9R7

    3. XM_008771076.4 → XP_008769298.1  HAUS augmin-like complex subunit 8 isoform X3

      UniProtKB/TrEMBL
      A6K9R7
      Conserved Domains (1) summary
      TIGR02168
      Location:165 → 376
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    4. XM_063275149.1 → XP_063131219.1  HAUS augmin-like complex subunit 8 isoform X6

    5. XM_008771074.4 → XP_008769296.1  HAUS augmin-like complex subunit 8 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JUK5, A6K9R7
      Related
      ENSRNOP00000069134.2
      Conserved Domains (1) summary
      TIGR02168
      Location:166 → 377
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    6. XM_039094287.2 → XP_038950215.1  HAUS augmin-like complex subunit 8 isoform X5

      UniProtKB/TrEMBL
      A0A8I5YCB2

    7. XM_039094286.2 → XP_038950214.1  HAUS augmin-like complex subunit 8 isoform X5

      UniProtKB/TrEMBL
      A0A8I5YCB2

    8. XM_063275147.1 → XP_063131217.1  HAUS augmin-like complex subunit 8 isoform X5

    9. XM_063275146.1 → XP_063131216.1  HAUS augmin-like complex subunit 8 isoform X5

    10. XM_063275148.1 → XP_063131218.1  HAUS augmin-like complex subunit 8 isoform X5

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5BK57.2 GenPept UniProtKB/Swiss-Prot:Q5BK57

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