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    Mpc1 mitochondrial pyruvate carrier 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171087, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Mpc1provided by RGD
    Official Full Name
    mitochondrial pyruvate carrier 1provided by RGD
    Primary source
    RGD:620902
    See related
    Ensembl:ENSRNOG00000012415 AllianceGenome:RGD:620902
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Brp44l; SLC54A1
    Summary
    Predicted to enable pyruvate transmembrane transporter activity. Predicted to be involved in mitochondrial pyruvate transmembrane transport. Predicted to act upstream of or within cellular response to leukemia inhibitory factor and mitochondrial acetyl-CoA biosynthetic process from pyruvate. Predicted to be located in mitochondrion. Predicted to be integral component of mitochondrial inner membrane. Human ortholog(s) of this gene implicated in mitochondrial pyruvate carrier deficiency. Orthologous to human MPC1 (mitochondrial pyruvate carrier 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 3557.4), Kidney (RPKM 2878.6) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mpc1 in Genome Data Viewer
    Location:
    1q12
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (54985305..54996979, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (52437745..52449399, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (53026608..53038229, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene proline rich 18 Neighboring gene SFT2 domain containing 1 Neighboring gene uncharacterized LOC134482722 Neighboring gene C-C motif chemokine receptor 6 Neighboring gene centrosomal protein 43 Neighboring gene uncharacterized LOC134484997

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mitochondrial pyruvate carrier 1 alleviates hypoxic-ischemic brain injury in rats. Liu Y, et al. Life Sci, 2023 Jul 15. PMID 37030616
    2. Inhibition of mitochondrial pyruvate carrier 1 by lapatinib ditosylate mitigates Alzheimer's-like disease in D-galactose/ovariectomized rats. Mansour HM, et al. Neurochem Int, 2021 Nov. PMID 34481907
    3. Identification and functional expression of the mitochondrial pyruvate carrier. Herzig S, et al. Science, 2012 Jul 6. PMID 22628554
    4. A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans. Bricker DK, et al. Science, 2012 Jul 6. PMID 22628558, Free PMC Article
    5. Proteomic analysis of the mouse liver mitochondrial inner membrane. Da Cruz S, et al. J Biol Chem, 2003 Oct 17. PMID 12865426

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mitochondrial pyruvate carrier 1 alleviates hypoxic-ischemic brain injury in rats.
      Title: Mitochondrial pyruvate carrier 1 alleviates hypoxic-ischemic brain injury in rats.
    2. Inhibition of mitochondrial pyruvate carrier 1 by lapatinib ditosylate mitigates Alzheimer's-like disease in D-galactose/ovariectomized rats.
      Title: Inhibition of mitochondrial pyruvate carrier 1 by lapatinib ditosylate mitigates Alzheimer's-like disease in D-galactose/ovariectomized rats.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables pyruvate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to pyruvate transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables pyruvate transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within acetyl-CoA biosynthetic process from pyruvate ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in acetyl-CoA biosynthetic process from pyruvate ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial pyruvate transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial pyruvate transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within mitochondrial pyruvate transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial pyruvate transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial pyruvate transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial pyruvate carrier 1
    Names
    apoptosis-regulating basic protein
    brain protein 44-like protein
    solute carrier family 54 member 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133561.2 → NP_598245.1  mitochondrial pyruvate carrier 1

      See identical proteins and their annotated locations for NP_598245.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      P63031, Q4V8N5
      Conserved Domains (1) summary
      pfam03650
      Location:24 → 105
      MPC; Uncharacterized protein family (UPF0041)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      54985305..54996979 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063274096.1 → XP_063130166.1  mitochondrial pyruvate carrier 1 isoform X3

      UniProtKB/Swiss-Prot
      P63031, Q4V8N5

    2. XM_063274062.1 → XP_063130132.1  mitochondrial pyruvate carrier 1 isoform X2

      UniProtKB/TrEMBL
      A6KK36

    3. XM_039086663.2 → XP_038942591.1  mitochondrial pyruvate carrier 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZR29, A0A8L2Q8K1, A6KK31
      Related
      ENSRNOP00000017282.6
      Conserved Domains (1) summary
      pfam03650
      Location:2 → 81
      MPC; Uncharacterized protein family (UPF0041)

    4. XM_063274001.1 → XP_063130071.1  mitochondrial pyruvate carrier 1 isoform X2

      UniProtKB/TrEMBL
      A6KK36
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P63031.1 GenPept UniProtKB/Swiss-Prot:P63031

    Gene LinkOut

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