Slc2a2 solute carrier family 2 member 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc2a2provided by RGD
Official Full Name: solute carrier family 2 member 2provided by RGD
Primary source: RGD:3705
See related: Ensembl:ENSRNOG00000011875 AllianceGenome:RGD:3705
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: GTT2; Glut2
Summary: Enables D-glucose transmembrane transporter activity; dehydroascorbic acid transmembrane transporter activity; and insulin receptor binding activity. Involved in several processes, including carbohydrate utilization; dehydroascorbic acid transport; and hexose transmembrane transport. Located in several cellular components, including apical plasma membrane; basolateral plasma membrane; and brush border membrane. Human ortholog(s) of this gene implicated in Fanconi syndrome; glycogen storage disease; and type 2 diabetes mellitus. Orthologous to human SLC2A2 (solute carrier family 2 member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 1233.6) and Kidney (RPKM 253.5) See more
Orthologs: human mouse all
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Genomic context

Location:: 2q24

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (113537884..113568422)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (111609798..111639930)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (114413427..114445418)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HCV affects KATP channels through GnT-IVa-mediated N-glycosylation of GLUT2 on the surface of pancreatic beta-cells leading to impaired insulin secretion.
Title: HCV affects K(ATP) channels through GnT-IVa-mediated N-glycosylation of GLUT2 on the surface of pancreatic β-cells leading to impaired insulin secretion.
Sex Dimorphic Glucose Transporter-2 Regulation of Hypothalamic Astrocyte Glucose and Energy Sensor Expression and Glycogen Metabolism.
Title: Sex Dimorphic Glucose Transporter-2 Regulation of Hypothalamic Astrocyte Glucose and Energy Sensor Expression and Glycogen Metabolism.
Perinatal stress exposure induced oxidative stress, metabolism disorder, and reduced GLUT-2 in adult offspring of rats.
Title: Perinatal stress exposure induced oxidative stress, metabolism disorder, and reduced GLUT-2 in adult offspring of rats.
Fructose-rich diet and walnut supplementation differently regulate rat hypothalamic and hippocampal glucose transporters expression.
Title: Fructose-rich diet and walnut supplementation differently regulate rat hypothalamic and hippocampal glucose transporters expression.
The Postnatal Offspring of Finasteride-Treated Male Rats Shows Hyperglycaemia, Elevated Hepatic Glycogen Storage and Altered GLUT2, IR, and AR Expression in the Liver.
Title: The Postnatal Offspring of Finasteride-Treated Male Rats Shows Hyperglycaemia, Elevated Hepatic Glycogen Storage and Altered GLUT2, IR, and AR Expression in the Liver.
Piperlongumine attenuates oxidative stress, inflammatory, and apoptosis through modulating the GLUT-2/4 and AKT signaling pathway in streptozotocin-induced diabetic rats.
Title: Piperlongumine attenuates oxidative stress, inflammatory, and apoptosis through modulating the GLUT-2/4 and AKT signaling pathway in streptozotocin-induced diabetic rats.
Glut2 and Glut4 regulate glucose transport during wound healing beneath the injured dental pulp area. This may contribute to the development of new vital pulp therapy for patients with deep caries
Title: Glucose Transporter 2 and 4 Are Involved in Glucose Supply during Pulpal Wound Healing after Pulpotomy with Mineral Trioxide Aggregate in Rat Molars.
activation of the p38MAPK alpha might be required for thyroid stimulating hormone-induced GLUT2 gene transcription in pancreatic beta cells.
Title: Thyroid stimulating hormone stimulates the expression of glucose transporter 2 via its receptor in pancreatic β cell line, INS-1 cells.
GLUT2 inhibition in tanycytes disrupted the hypothalamic glucosensing mechanism that controls feeding behavior. Inhibition of GLUT2 expression resulted in increased food intake and a gain in body weight in rats.
Title: Glial hypothalamic inhibition of GLUT2 expression alters satiety, impacting eating behavior.
A single low streptozotocin (STZ) dose into the lateral ventricles of the adult rats induces wide-spread neuroinflammation in the cortical, hippocampal and hypothalamic regions and more regional-specific alterations in GLUT2 and insulin receptor (IR) protein expression, observed as early as 1 h after the treatment. GLUT2 and IR expression was altered in areas close to the site of STZ release and downstream the CSF flow.
Title: Rat brain glucose transporter-2, insulin receptor and glial expression are acute targets of intracerebroventricular streptozotocin: risk factors for sporadic Alzheimer's disease?

Submit: New GeneRIF Correction See all GeneRIFs (54)

General gene information

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Markers

RH127898 (e-PCR)
- UniSTS:211208

RH94421 (e-PCR)
- UniSTS:119669

D2Wox47 (e-PCR)
- UniSTS:240044

RH94776 (e-PCR)
- UniSTS:120023

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables D-glucose transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables D-glucose transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables D-glucose transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables D-glucose transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables dehydroascorbic acid transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables dehydroascorbic acid transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables dehydroascorbic acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables fructose transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables fructose transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables fructose transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables galactose transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables galactose transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables galactose transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables glucose transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables glucose transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables glucose transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables insulin receptor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in carbohydrate utilization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to fatty acid	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to organic cyclic compound	IDA Inferred from Direct Assay more info	PubMed
involved_in dehydroascorbic acid transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in dehydroascorbic acid transport	IDA Inferred from Direct Assay more info	PubMed
involved_in dehydroascorbic acid transport	IEA Inferred from Electronic Annotation more info
involved_in dehydroascorbic acid transport	ISO Inferred from Sequence Orthology more info
involved_in fructose transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in fructose transmembrane transport	IEP Inferred from Expression Pattern more info	PubMed
involved_in fructose transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in fructose transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in galactose transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in galactose transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in galactose transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in glucose import	IBA Inferred from Biological aspect of Ancestor more info
involved_in glucose transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in glucose transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in glucose transmembrane transport	IEP Inferred from Expression Pattern more info	PubMed
involved_in glucose transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus	ISO Inferred from Sequence Orthology more info
involved_in response to glucose	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to peptide hormone	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in brush border	IBA Inferred from Biological aspect of Ancestor more info
located_in brush border	IDA Inferred from Direct Assay more info	PubMed
located_in brush border	IEA Inferred from Electronic Annotation more info
located_in brush border	ISO Inferred from Sequence Orthology more info
located_in brush border membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cell-cell junction	IEA Inferred from Electronic Annotation more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: solute carrier family 2, facilitated glucose transporter member 2

Names: GLUT-2; glucose transporter type 2, liver; solute carrier family 2 (facilitated glucose transporter), member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012879.2 → NP_037011.2 solute carrier family 2, facilitated glucose transporter member 2

See identical proteins and their annotated locations for NP_037011.2

Status: PROVISIONAL

Source sequence(s)

BC078875

UniProtKB/Swiss-Prot

P12336, Q6LE98

UniProtKB/TrEMBL

Q68FZ1

Related

ENSRNOP00000015866.3, ENSRNOT00000015866.7

Conserved Domains (1) summary

cd17431
Location:12 → 488

MFS_GLUT_Class1; Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

113537884..113568422

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039101783.2 → XP_038957711.1 solute carrier family 2, facilitated glucose transporter member 2 isoform X1

UniProtKB/Swiss-Prot

P12336, Q6LE98

UniProtKB/TrEMBL

Q68FZ1

Conserved Domains (1) summary

cd17431
Location:12 → 488

MFS_GLUT_Class1; Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily