Laptm4b lysosomal protein transmembrane 4 beta [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Laptm4bprovided by RGD
Official Full Name: lysosomal protein transmembrane 4 betaprovided by RGD
Primary source: RGD:1311853
See related: Ensembl:ENSRNOG00000006766 AllianceGenome:RGD:1311853
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable ceramide binding activity; enzyme binding activity; and phosphatidylinositol bisphosphate binding activity. Predicted to be involved in several processes, including negative regulation of macromolecule metabolic process; regulation of lysosomal membrane permeability; and regulation of lysosome organization. Predicted to be located in several cellular components, including endosome; lysosome; and plasma membrane. Predicted to be active in lysosomal membrane. Orthologous to human LAPTM4B (lysosomal protein transmembrane 4 beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 592.1), Testes (RPKM 329.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q22

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (67319438..67362547)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (65434525..65477386)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (72924911..72968099)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Downregulation of LAPTM4B Contributes to the Impairment of the Autophagic Flux via Unopposed Activation of mTORC1 Signaling During Myocardial Ischemia/Reperfusion Injury.
Title: Downregulation of LAPTM4B Contributes to the Impairment of the Autophagic Flux via Unopposed Activation of mTORC1 Signaling During Myocardial Ischemia/Reperfusion Injury.

Submit: New GeneRIF Correction

General gene information

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Markers

RH134681 (e-PCR)
- UniSTS:217960

RH128820 (e-PCR)
- UniSTS:212128

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ceramide binding	IEA Inferred from Electronic Annotation more info
enables ceramide binding	ISO Inferred from Sequence Orthology more info
enables ceramide binding	ISS Inferred from Sequence or Structural Similarity more info
enables kinase binding	IEA Inferred from Electronic Annotation more info
enables kinase binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol bisphosphate binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol bisphosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol bisphosphate binding	ISS Inferred from Sequence or Structural Similarity more info
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in endosome organization	IEA Inferred from Electronic Annotation more info
involved_in endosome organization	ISO Inferred from Sequence Orthology more info
involved_in endosome organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in endosome transport via multivesicular body sorting pathway	IEA Inferred from Electronic Annotation more info
involved_in endosome transport via multivesicular body sorting pathway	ISO Inferred from Sequence Orthology more info
involved_in endosome transport via multivesicular body sorting pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of lysosomal protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of lysosomal protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of lysosomal protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of transforming growth factor beta1 production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transforming growth factor beta1 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transforming growth factor beta1 production	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of lysosomal membrane permeability	IEA Inferred from Electronic Annotation more info
involved_in regulation of lysosomal membrane permeability	ISO Inferred from Sequence Orthology more info
involved_in regulation of lysosomal membrane permeability	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of lysosome organization	IEA Inferred from Electronic Annotation more info
involved_in regulation of lysosome organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of lysosome organization	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cell projection	ISO Inferred from Sequence Orthology more info
located_in cell projection	ISS Inferred from Sequence or Structural Similarity more info
located_in early endosome	IEA Inferred from Electronic Annotation more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in early endosome	ISS Inferred from Sequence or Structural Similarity more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in endosome	ISS Inferred from Sequence or Structural Similarity more info
located_in late endosome membrane	ISO Inferred from Sequence Orthology more info
located_in late endosome membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in lysosomal membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info
located_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
located_in lysosomal membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in lysosome	ISS Inferred from Sequence or Structural Similarity more info
located_in multivesicular body membrane	IEA Inferred from Electronic Annotation more info
located_in multivesicular body membrane	ISO Inferred from Sequence Orthology more info
located_in multivesicular body membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in multivesicular body, internal vesicle	IEA Inferred from Electronic Annotation more info
located_in multivesicular body, internal vesicle	ISO Inferred from Sequence Orthology more info
located_in multivesicular body, internal vesicle	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: lysosomal-associated transmembrane protein 4B

Names: lysosomal-associated protein transmembrane 4B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013174.1 → NP_001013192.1 lysosomal-associated transmembrane protein 4B

See identical proteins and their annotated locations for NP_001013192.1

Status: PROVISIONAL

Source sequence(s)

BC086442

UniProtKB/Swiss-Prot

Q5U1W4

UniProtKB/TrEMBL

A6HQZ5

Related

ENSRNOP00000008969.4, ENSRNOT00000008969.7

Conserved Domains (1) summary

cl04276
Location:9 → 227

Mtp; Golgi 4-transmembrane spanning transporter

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

67319438..67362547

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039079227.2 → XP_038935155.1 lysosomal-associated transmembrane protein 4B isoform X1

UniProtKB/TrEMBL

A0A8I5ZNQ3

Related

ENSRNOP00000079765.1

Conserved Domains (1) summary

cl04276
Location:73 → 229

Mtp; Golgi 4-transmembrane spanning transporter