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    Spice1 spindle and centriole associated protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 288111, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Spice1provided by RGD
    Official Full Name
    spindle and centriole associated protein 1provided by RGD
    Primary source
    RGD:1310729
    See related
    Ensembl:ENSRNOG00000039024 AllianceGenome:RGD:1310729
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ccdc52; RGD1310729
    Summary
    Predicted to be involved in metaphase plate congression; mitotic spindle assembly; and regulation of centriole replication. Predicted to be located in cytoplasm. Predicted to be active in centriole; centrosome; and spindle. Orthologous to human SPICE1 (spindle and centriole associated protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 26.8), Lung (RPKM 23.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Spice1 in Genome Data Viewer
    Location:
    11q21
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (69796490..69838304, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (56289291..56332382, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (61250649..61294116, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene cilia and flagella associated protein 44 Neighboring gene uncharacterized LOC120095657 Neighboring gene uncharacterized LOC134481069 Neighboring gene SID1 transmembrane family, member 1 Neighboring gene U2 spliceosomal RNA Neighboring gene upstream transcription factor family member 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. SPICE--a previously uncharacterized protein required for centriole duplication and mitotic chromosome congression. Archinti M, et al. J Cell Sci, 2010 Sep 15. PMID 20736305
    2. Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. Jakobsen L, et al. EMBO J, 2011 Apr 20. PMID 21399614, Free PMC Article
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC95293

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in metaphase chromosome alignment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic spindle assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of centriole replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of centriole replication ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centriole ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in spindle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    spindle and centriole-associated protein 1
    Names
    coiled-coil domain containing 52
    coiled-coil domain-containing protein 52

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008285.1 → NP_001008286.1  spindle and centriole-associated protein 1

      See identical proteins and their annotated locations for NP_001008286.1

      Status: PROVISIONAL

      Source sequence(s)
      BC085954
      UniProtKB/Swiss-Prot
      Q5RKG1
      UniProtKB/TrEMBL
      A0A0G2JX08
      Related
      ENSRNOP00000061013.1, ENSRNOT00000064385.2
      Conserved Domains (1) summary
      pfam15678
      Location:33 → 434
      SPICE; Centriole duplication and mitotic chromosome congression

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      69796490..69838304 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008768719.4 → XP_008766941.1  spindle and centriole-associated protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JX08
      Conserved Domains (1) summary
      pfam15678
      Location:33 → 434
      SPICE; Centriole duplication and mitotic chromosome congression

    2. XM_063270392.1 → XP_063126462.1  spindle and centriole-associated protein 1 isoform X2

    3. XM_063270391.1 → XP_063126461.1  spindle and centriole-associated protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q5RKG1

    4. XM_006248332.5 → XP_006248394.1  spindle and centriole-associated protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006248394.1

      UniProtKB/Swiss-Prot
      Q5RKG1
      UniProtKB/TrEMBL
      A0A0G2JX08
      Conserved Domains (1) summary
      pfam15678
      Location:33 → 434
      SPICE; Centriole duplication and mitotic chromosome congression

    5. XM_006248334.4 → XP_006248396.1  spindle and centriole-associated protein 1 isoform X3

      See identical proteins and their annotated locations for XP_006248396.1

      UniProtKB/TrEMBL
      A0A8I5ZMT5
      Conserved Domains (1) summary
      pfam15678
      Location:1 → 381
      SPICE; Centriole duplication and mitotic chromosome congression

    RNA

    1. XR_005491006.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5RKG1.1 GenPept UniProtKB/Swiss-Prot:Q5RKG1

    Gene LinkOut

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