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    Nrros negative regulator of reactive oxygen species [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303875, updated on 2-May-2024

    Summary

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    Official Symbol
    Nrrosprovided by RGD
    Official Full Name
    negative regulator of reactive oxygen speciesprovided by RGD
    Primary source
    RGD:1310771
    See related
    Ensembl:ENSRNOG00000001752 AllianceGenome:RGD:1310771
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Garpl1; Lrrc33; RGD1310771
    Summary
    Predicted to enable transforming growth factor beta binding activity. Predicted to be involved in several processes, including microglia development; sequestering of TGFbeta in extracellular matrix; and transforming growth factor beta1 activation. Predicted to be located in cell surface and endoplasmic reticulum. Orthologous to human NRROS (negative regulator of reactive oxygen species). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 284.4), Spleen (RPKM 276.1) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nrros in Genome Data Viewer
    Location:
    11q22
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (82133608..82151160)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (68628641..68646152)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (71872728..71889897)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481089 Neighboring gene uncharacterized LOC120095670 Neighboring gene uncharacterized LOC134481090 Neighboring gene centrosomal protein 19 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class X Neighboring gene small nucleolar RNA SNORA17 Neighboring gene p21 (RAC1) activated kinase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mice deficient in NRROS show abnormal microglial development and neurological disorders. Wong K, et al. Nat Immunol, 2017 Jun. PMID 28459434
    2. A Milieu Molecule for TGF-β Required for Microglia Function in the Nervous System. Qin Y, et al. Cell, 2018 Jun 28. PMID 29909984, Free PMC Article
    3. NRROS negatively regulates reactive oxygen species during host defence and autoimmunity. Noubade R, et al. Nature, 2014 May 8. PMID 24739962
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC108848

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables receptor ligand inhibitor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables transforming growth factor beta binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transforming growth factor beta binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transforming growth factor beta binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in inflammatory response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    NOT involved_in innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT involved_in innate immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in microglia development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in microglia development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microglia development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in sequestering of TGFbeta in extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sequestering of TGFbeta in extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sequestering of TGFbeta in extracellular matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in superoxide metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT involved_in superoxide metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in superoxide metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT involved_in superoxide metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in transforming growth factor beta receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transforming growth factor beta receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transforming growth factor beta receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell surface ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transforming growth factor beta activator LRRC33
    Names
    leucine rich repeat containing 33
    leucine-rich repeat-containing protein 33
    leucine-rich repeat-containing protein 33^

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024995.1 → NP_001020166.1  transforming growth factor beta activator LRRC33 precursor

      See identical proteins and their annotated locations for NP_001020166.1

      Status: PROVISIONAL

      Source sequence(s)
      BC091190
      UniProtKB/Swiss-Prot
      Q5BK65
      UniProtKB/TrEMBL
      A0A8I5Y5F1, A6IRT2
      Related
      ENSRNOP00000048680.3, ENSRNOT00000050364.4
      Conserved Domains (4) summary
      cd00116
      Location:328 → 549
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:330 → 353
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:537 → 574
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:157 → 217
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      82133608..82151160
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006248448.5 → XP_006248510.1  transforming growth factor beta activator LRRC33 isoform X1

      See identical proteins and their annotated locations for XP_006248510.1

      UniProtKB/Swiss-Prot
      Q5BK65
      UniProtKB/TrEMBL
      A0A8I5Y5F1, A6IRT2
      Conserved Domains (4) summary
      cd00116
      Location:328 → 549
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:330 → 353
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:537 → 574
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:157 → 217
      LRR_8; Leucine rich repeat
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5BK65.1 GenPept UniProtKB/Swiss-Prot:Q5BK65

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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