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    Cdh24 cadherin-like 24 [ Mus musculus (house mouse) ]

    Gene ID: 239096, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Cdh24provided by MGI
    Official Full Name
    cadherin-like 24provided by MGI
    Primary source
    MGI:MGI:1928330
    See related
    Ensembl:ENSMUSG00000059674 AllianceGenome:MGI:1928330
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1700040A22Rik
    Summary
    Predicted to enable several functions, including alpha-catenin binding activity; beta-catenin binding activity; and delta-catenin binding activity. Predicted to be involved in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; cell morphogenesis; and cell-cell junction organization. Predicted to act upstream of or within cell-cell adhesion. Predicted to be located in cell-cell junction. Predicted to be part of catenin complex. Predicted to be active in adherens junction. Is expressed in brain and retina. Orthologous to human CDH24 (cadherin 24). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in thymus adult (RPKM 40.1), whole brain E14.5 (RPKM 18.9) and 14 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cdh24 in Genome Data Viewer
    Location:
    14 C2; 14 27.87 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (54868688..54878853, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (54631231..54642067, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr14:55236824-55237125 Neighboring gene proteasome (prosome, macropain) subunit, beta type 5 Neighboring gene microRNA 686 Neighboring gene proteasome (prosome, macropain) subunit, beta type, 11 Neighboring gene microRNA 6948 Neighboring gene apoptotic chromatin condensation inducer 1 Neighboring gene RIKEN cDNA 4930579G18 gene Neighboring gene STARR-positive B cell enhancer ABC_E1473

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Multiple cadherin mRNA expression and developmental regulation of a novel cadherin in the developing mouse eye. Faulkner-Jones BE, et al. Exp Neurol, 1999 Apr. PMID 10328938
    2. Comparative analysis of type II classic cadherin mRNA distribution patterns in the developing and adult mouse somatosensory cortex and hippocampus suggests significant functional redundancy. Lefkovics K, et al. J Comp Neurol, 2012 May 1. PMID 22102170
    3. Differential Spatiotemporal Expression of Type I and Type II Cadherins Associated With the Segmentation of the Central Nervous System and Formation of Brain Nuclei in the Developing Mouse. Polanco J, et al. Front Mol Neurosci, 2021. PMID 33833667, Free PMC Article
    4. Type II cadherins guide assembly of a direction-selective retinal circuit. Duan X, et al. Cell, 2014 Aug 14. PMID 25126785
    5. A dual-strategy expression screen for candidate connectivity labels in the developing thalamus. Bibollet-Bahena O, et al. PLoS One, 2017. PMID 28558017, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC67331

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables alpha-catenin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables beta-catenin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables beta-catenin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cadherin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables delta-catenin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in adherens junction organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell-cell adhesion mediated by cadherin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell junction assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in multicellular organism development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in adherens junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of catenin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cadherin-24
    Names
    EY-cadherin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199470.3 → NP_955764.1  cadherin-24 precursor

      See identical proteins and their annotated locations for NP_955764.1

      Status: VALIDATED

      Source sequence(s)
      CT009512
      Consensus CDS
      CCDS36923.1
      UniProtKB/Swiss-Prot
      Q6PFX6
      Related
      ENSMUSP00000066005.7, ENSMUST00000067784.8
      Conserved Domains (4) summary
      cd11304
      Location:378 → 475
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:70 → 148
      CA; Cadherin repeats
      cl29226
      Location:485 → 577
      Cadherin; Cadherin domain
      pfam01049
      Location:625 → 776
      Cadherin_C; Cadherin cytoplasmic region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      54868688..54878853 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247794.2 → XP_030103654.1  cadherin-24 isoform X2

      Conserved Domains (2) summary
      cd11304
      Location:154 → 255
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:70 → 148
      CA; Cadherin repeats

    2. XM_006518975.5 → XP_006519038.1  cadherin-24 isoform X3

      Conserved Domains (2) summary
      cd11304
      Location:154 → 255
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:70 → 148
      CA; Cadherin repeats
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PFX6.1 GenPept UniProtKB/Swiss-Prot:Q6PFX6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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