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    MORF4 mortality factor 4 (pseudogene) [ Homo sapiens (human) ]

    Gene ID: 10934, updated on 10-Oct-2023

    Summary

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    Official Symbol
    MORF4provided by HGNC
    Official Full Name
    mortality factor 4 (pseudogene)provided by HGNC
    Primary source
    HGNC:HGNC:15773
    See related
    MIM:116960; AllianceGenome:HGNC:15773
    Gene type
    pseudo
    RefSeq status
    INFERRED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CSR; SEN; CSRB; SEN1
    Summary
    Cellular senescence, the terminal nondividing state that normal cells enter following completion of their proliferative potential, is the dominant phenotype in hybrids of normal and immortal cells. Fusions of immortal human cell lines with each other have led to their assignment to 1 of several complementation groups. MORF4 is a gene on chromosome 4 that induces a senescent-like phenotype in cell lines assigned to complementation group B.[supplied by OMIM, Apr 2004]
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    Genomic context

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    See MORF4 in Genome Data Viewer
    Location:
    4q34.1
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (173615736..173616842, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (176955498..176956606, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (174536887..174537993, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene HAND2 antisense RNA 1 Neighboring gene uncharacterized LOC124900816 Neighboring gene NANOG hESC enhancer GRCh37_chr4:174457885-174458386 Neighboring gene heart and neural crest derivatives expressed 2 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:174529467-174530044 Neighboring gene RAN pseudogene 6 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr4:174617544-174618743 Neighboring gene uncharacterized LOC107986203

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Emerging role of the MORF/MRG gene family in various biological processes, including aging. Chen M, et al. Ann N Y Acad Sci, 2010 Jun. PMID 20536842, Free PMC Article
    2. The cell senescence inducing gene product MORF4 is regulated by degradation via the ubiquitin/proteasome pathway. Tominaga K, et al. Exp Cell Res, 2010 Jan 1. PMID 19769966, Free PMC Article
    3. A mortality gene(s) for the human adenocarcinoma line HeLa maps to a 130-kb region of human chromosome 4q22-q23. Bryce SD, et al. Neoplasia, 2002 Nov-Dec. PMID 12407449, Free PMC Article
    4. Genetic approaches to the study of replicative senescence. Ran Q, et al. Exp Gerontol, 2000 Feb. PMID 10705034
    5. Genetic and functional analyses exclude mortality factor 4 (MORF4) as a keratinocyte senescence gene. Bryce SD, et al. Cancer Res, 1999 May 1. PMID 10232582

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MORF4 is a highly unstable protein and is rapidly degraded by the ubiquitin/ proteasome pathway in cancer cells.
      Title: The cell senescence inducing gene product MORF4 is regulated by degradation via the ubiquitin/proteasome pathway.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Variation

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    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Other Names

    • mortality factor 4 like 1 pseudogene
    • senescence (cellular)-related 1
    • senescence-related, cellular, 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_028235.2 

      Range
      1..1107
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      173615736..173616842 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      176955498..176956606 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_006792.2: Suppressed sequence

      Description
      NM_006792.2: This RefSeq was permanently suppressed because it is now thought that this gene is a pseudogene.
    Nucleotide Protein
    Heading Accession and Version

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