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    Hectd4 HECT domain E3 ubiquitin protein ligase 4 [ Mus musculus (house mouse) ]

    Gene ID: 269700, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Hectd4provided by MGI
    Official Full Name
    HECT domain E3 ubiquitin protein ligase 4provided by MGI
    Primary source
    MGI:MGI:3647820
    See related
    Ensembl:ENSMUSG00000042744 AllianceGenome:MGI:3647820
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm15800; EG545802; mKIAA0614; A130010L24
    Summary
    Predicted to be involved in glucose homeostasis and glucose metabolic process. Is expressed in several structures, including extraembryonic component; nervous system; neural retina; reproductive system; and tongue. Orthologous to human HECTD4 (HECT domain E3 ubiquitin protein ligase 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 19.5), whole brain E14.5 (RPKM 18.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Hectd4 in Genome Data Viewer
    Location:
    5 F; 5 61.72 cM
    Exon count:
    79
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (121357323..121506633)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (121219513..121368577)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase, non-receptor type 11 Neighboring gene STARR-positive B cell enhancer ABC_E4783 Neighboring gene STARR-positive B cell enhancer ABC_E6372 Neighboring gene STARR-seq mESC enhancer starr_14255 Neighboring gene STARR-positive B cell enhancer ABC_E4784 Neighboring gene predicted gene, 26205 Neighboring gene ribosomal protein L6 Neighboring gene STARR-positive B cell enhancer mm9_chr5:121780251-121780552 Neighboring gene predicted gene, 24671 Neighboring gene STARR-positive B cell enhancer ABC_E1688 Neighboring gene TRAF type zinc finger domain containing 1 Neighboring gene predicted gene, 42020 Neighboring gene N(alpha)-acetyltransferase 25, NatB auxiliary subunit Neighboring gene STARR-seq mESC enhancer starr_14257

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Upregulation of imprinted genes in mice: an insight into the intensity of gene expression and the evolution of genomic imprinting. Zaitoun I, et al. Epigenetics, 2010 Feb 16. PMID 20168089, Free PMC Article
    2. Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling. Angrand PO, et al. Mol Cell Proteomics, 2006 Dec. PMID 16959763
    3. Transcriptome analysis of mouse stem cells and early embryos. Sharov AA, et al. PLoS Biol, 2003 Dec. PMID 14691545, Free PMC Article
    4. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
    5. An Interaction Landscape of Ubiquitin Signaling. Zhang X, et al. Mol Cell, 2017 Mar 2. PMID 28190767

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in glucose homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glucose homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glucose metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    probable E3 ubiquitin-protein ligase HECTD4
    NP_852086.3
    XP_006530414.1
    XP_006530415.1
    XP_006530416.1
    XP_006530417.1
    XP_006530418.1
    XP_006530419.1
    XP_006530420.1
    XP_006530421.3
    XP_006530423.1
    XP_011246506.1
    XP_030110401.1
    XP_036021046.1
    XP_036021047.1
    XP_036021048.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_181421.5 → NP_852086.3  probable E3 ubiquitin-protein ligase HECTD4

      Status: VALIDATED

      Source sequence(s)
      AC110037, AC126938
      Consensus CDS
      CCDS57377.1
      UniProtKB/TrEMBL
      E9Q2E4
      Related
      ENSMUSP00000048345.7, ENSMUST00000042614.13
      Conserved Domains (3) summary
      smart00119
      Location:4060 → 4409
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd13735
      Location:2400 → 2555
      SPRY_HECT_like; SPRY domain in HECT E3
      cl00077
      Location:4020 → 4413
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      121357323..121506633
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006530351.5 → XP_006530414.1  probable E3 ubiquitin-protein ligase HECTD4 isoform X1

      Conserved Domains (3) summary
      cd13735
      Location:2507 → 2662
      SPRY_HECT_like; SPRY domain in HECT E3
      pfam15450
      Location:149 → 233
      CCDC154; Coiled-coil domain-containing protein 154
      cl27008
      Location:4127 → 4520
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

    2. XM_006530353.5 → XP_006530416.1  probable E3 ubiquitin-protein ligase HECTD4 isoform X3

      Conserved Domains (3) summary
      cd13735
      Location:2507 → 2662
      SPRY_HECT_like; SPRY domain in HECT E3
      pfam15450
      Location:149 → 233
      CCDC154; Coiled-coil domain-containing protein 154
      cl27008
      Location:4126 → 4519
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

    3. XM_006530352.5 → XP_006530415.1  probable E3 ubiquitin-protein ligase HECTD4 isoform X2

      Conserved Domains (3) summary
      cd13735
      Location:2506 → 2661
      SPRY_HECT_like; SPRY domain in HECT E3
      pfam15450
      Location:149 → 233
      CCDC154; Coiled-coil domain-containing protein 154
      cl27008
      Location:4126 → 4519
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

    4. XM_006530355.5 → XP_006530418.1  probable E3 ubiquitin-protein ligase HECTD4 isoform X5

      Conserved Domains (3) summary
      cd13735
      Location:2502 → 2657
      SPRY_HECT_like; SPRY domain in HECT E3
      pfam15450
      Location:149 → 233
      CCDC154; Coiled-coil domain-containing protein 154
      cl27008
      Location:4122 → 4515
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

    5. XM_006530356.5 → XP_006530419.1  probable E3 ubiquitin-protein ligase HECTD4 isoform X6

      Conserved Domains (3) summary
      cd13735
      Location:2498 → 2653
      SPRY_HECT_like; SPRY domain in HECT E3
      pfam15450
      Location:149 → 233
      CCDC154; Coiled-coil domain-containing protein 154
      cl27008
      Location:4118 → 4511
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

    6. XM_006530360.5 → XP_006530423.1  probable E3 ubiquitin-protein ligase HECTD4 isoform X8

      Conserved Domains (3) summary
      cd13735
      Location:2493 → 2648
      SPRY_HECT_like; SPRY domain in HECT E3
      pfam15450
      Location:149 → 233
      CCDC154; Coiled-coil domain-containing protein 154
      cl27008
      Location:4113 → 4506
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

    7. XM_006530354.5 → XP_006530417.1  probable E3 ubiquitin-protein ligase HECTD4 isoform X4

      Conserved Domains (3) summary
      cd13735
      Location:2505 → 2660
      SPRY_HECT_like; SPRY domain in HECT E3
      pfam15450
      Location:149 → 233
      CCDC154; Coiled-coil domain-containing protein 154
      cl27008
      Location:4125 → 4518
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

    8. XM_006530357.5 → XP_006530420.1  probable E3 ubiquitin-protein ligase HECTD4 isoform X7

      Conserved Domains (3) summary
      cd13735
      Location:2496 → 2651
      SPRY_HECT_like; SPRY domain in HECT E3
      pfam15450
      Location:149 → 233
      CCDC154; Coiled-coil domain-containing protein 154
      cl27008
      Location:4116 → 4509
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

    9. XM_036165153.1 → XP_036021046.1  probable E3 ubiquitin-protein ligase HECTD4 isoform X9

      Conserved Domains (2) summary
      cd13735
      Location:2422 → 2577
      SPRY_HECT_like; SPRY domain in HECT E3
      cl27008
      Location:4042 → 4435
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

    10. XM_036165154.1 → XP_036021047.1  probable E3 ubiquitin-protein ligase HECTD4 isoform X10

      Conserved Domains (2) summary
      cd13735
      Location:2420 → 2575
      SPRY_HECT_like; SPRY domain in HECT E3
      cl27008
      Location:4040 → 4433
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

    11. XM_030254541.1 → XP_030110401.1  probable E3 ubiquitin-protein ligase HECTD4 isoform X14

      Conserved Domains (2) summary
      cd13735
      Location:1894 → 2049
      SPRY_HECT_like; SPRY domain in HECT E3
      cl27008
      Location:3514 → 3907
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

    12. XM_006530358.5 → XP_006530421.3  probable E3 ubiquitin-protein ligase HECTD4 isoform X11

      Conserved Domains (2) summary
      cd13735
      Location:2389 → 2544
      SPRY_HECT_like; SPRY domain in HECT E3
      cl27008
      Location:4009 → 4402
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

    13. XM_036165155.1 → XP_036021048.1  probable E3 ubiquitin-protein ligase HECTD4 isoform X13

      Conserved Domains (2) summary
      cd13735
      Location:2124 → 2279
      SPRY_HECT_like; SPRY domain in HECT E3
      cl27008
      Location:3744 → 4137
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

    14. XM_011248204.4 → XP_011246506.1  probable E3 ubiquitin-protein ligase HECTD4 isoform X12

      Conserved Domains (2) summary
      cd13735
      Location:2377 → 2532
      SPRY_HECT_like; SPRY domain in HECT E3
      cl27008
      Location:3997 → 4390
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    Nucleotide Protein Strain
    Heading Accession and Version

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