Unc13a unc-13 homolog A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Unc13aprovided by MGI
Official Full Name: unc-13 homolog Aprovided by MGI
Primary source: MGI:MGI:3051532
See related: Ensembl:ENSMUSG00000034799 AllianceGenome:MGI:3051532
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Munc13-1; 2410078G03Rik
Summary: Enables diacylglycerol binding activity. Involved in several processes, including positive regulation of glutamate receptor signaling pathway; positive regulation of synaptic plasticity; and synaptic vesicle exocytosis. Acts upstream of or within several processes, including amyloid-beta metabolic process; chemical synaptic transmission; and modulation of chemical synaptic transmission. Located in calyx of Held and neuromuscular junction. Is active in glutamatergic synapse and presynaptic active zone. Is expressed in nervous system and neural retina. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis. Orthologous to human UNC13A (unc-13 homolog A). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cortex adult (RPKM 45.3), frontal lobe adult (RPKM 39.2) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 B3.3; 8 34.43 cM

Exon count:: 46

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (72079356..72124418, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (71624125..71671774, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variability in the Munc13-1 content of excitatory release sites.
Title: Variability in the Munc13-1 content of excitatory release sites.
Heterogeneous Presynaptic Distribution of Munc13 Isoforms at Retinal Synapses and Identification of an Unconventional Bipolar Cell Type with Dual Expression of Munc13 Isoforms: A Study Using Munc13-EXFP Knock-in Mice.
Title: Heterogeneous Presynaptic Distribution of Munc13 Isoforms at Retinal Synapses and Identification of an Unconventional Bipolar Cell Type with Dual Expression of Munc13 Isoforms: A Study Using Munc13-EXFP Knock-in Mice.
Munc13 activates the Munc18-1/syntaxin-1 complex and enables Munc18-1 to prime SNARE assembly.
Title: Munc13 activates the Munc18-1/syntaxin-1 complex and enables Munc18-1 to prime SNARE assembly.
Disentangling the Roles of RIM and Munc13 in Synaptic Vesicle Localization and Neurotransmission.
Title: Disentangling the Roles of RIM and Munc13 in Synaptic Vesicle Localization and Neurotransmission.
Data suggest that the Munc13-1/2 heterodimer is an active component of the vesicle docking, priming and release complex.
Title: Heterodimerization of Munc13 C(2)A domain with RIM regulates synaptic vesicle docking and priming.
Synaptic UNC13A protein variant causes increased neurotransmission and dyskinetic movement disorder
Title: Synaptic UNC13A protein variant causes increased neurotransmission and dyskinetic movement disorder.
CAPS1 binds to the full-length of cytoplasmic syntaxin-1 with preference to its "open" conformation, whereas Munc13-1 binds to the first 80 N-terminal residues of syntaxin-1.
Title: Calcium-dependent activator protein for secretion 1 (CAPS1) binds to syntaxin-1 in a distinct mode from Munc13-1.
Rab37 interacts with Munc13-1 to control TNF-alpha secretion from activated macrophages
Title: Release of TNF-α from macrophages is mediated by small GTPase Rab37.
These results indicate that synaptic vesicle docking at the plasma membrane and functional priming are respective morphological and physiological manifestations of the same molecular process mediated by SNARE complexes and Munc13-1/2s.
Title: A common molecular basis for membrane docking and functional priming of synaptic vesicles.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (7) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH126876 (e-PCR)
- UniSTS:209756

NoName (e-PCR)
- UniSTS:235925

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables SNARE binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calmodulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin binding	IDA Inferred from Direct Assay more info	PubMed
enables calmodulin binding	ISO Inferred from Sequence Orthology more info
enables diacylglycerol binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phospholipid binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables spectrin binding	ISO Inferred from Sequence Orthology more info
enables syntaxin binding	ISO Inferred from Sequence Orthology more info
enables syntaxin-1 binding	IBA Inferred from Biological aspect of Ancestor more info
enables syntaxin-1 binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within amyloid-beta metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
NOT involved_in dense core granule docking	IGI Inferred from Genetic Interaction more info	PubMed
involved_in dense core granule priming	IBA Inferred from Biological aspect of Ancestor more info
involved_in dense core granule priming	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within exocytosis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within innervation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in long-term synaptic potentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuromuscular junction development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in neuronal dense core vesicle exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of neurotransmitter secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neurotransmitter secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendrite extension	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glutamate receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of neurotransmitter secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of synaptic plasticity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in presynaptic dense core vesicle exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in presynaptic dense core vesicle exocytosis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of amyloid precursor protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of short-term neuronal synaptic plasticity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synaptic vesicle priming	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic vesicle priming	TAS Traceable Author Statement more info	PubMed
involved_in synaptic transmission, glutamatergic	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within synaptic transmission, glutamatergic	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within synaptic transmission, glutamatergic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle docking	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within synaptic vesicle docking	IGI Inferred from Genetic Interaction more info	PubMed
involved_in synaptic vesicle exocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in synaptic vesicle exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within synaptic vesicle maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle priming	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic vesicle priming	IGI Inferred from Genetic Interaction more info	PubMed
involved_in synaptic vesicle priming	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle priming	ISO Inferred from Sequence Orthology more info
involved_in synaptic vesicle priming	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi-associated vesicle	ISO Inferred from Sequence Orthology more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
is_active_in calyx of Held	IDA Inferred from Direct Assay more info	PubMed
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in excitatory synapse	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in neuromuscular junction	IBA Inferred from Biological aspect of Ancestor more info
located_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in presynapse	IDA Inferred from Direct Assay more info	PubMed
located_in presynaptic active zone	IC Inferred by Curator more info	PubMed
is_active_in presynaptic active zone	IDA Inferred from Direct Assay more info	PubMed
located_in presynaptic active zone	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic active zone cytoplasmic component	IBA Inferred from Biological aspect of Ancestor more info
located_in presynaptic active zone cytoplasmic component	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in presynaptic membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic membrane	ISO Inferred from Sequence Orthology more info
is_active_in synaptic vesicle membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in terminal bouton	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein unc-13 homolog A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001029873.2 → NP_001025044.2 protein unc-13 homolog A

See identical proteins and their annotated locations for NP_001025044.2

Status: VALIDATED

Source sequence(s)

AK147408, CB250050, CJ106055, CJ250255

Consensus CDS

CCDS22402.2

UniProtKB/Swiss-Prot

E9QKH9, Q3UHG2, Q4KUS2

Related

ENSMUSP00000030170.9, ENSMUST00000030170.15

Conserved Domains (6) summary

cd04027
Location:685 → 811

C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins

cd08394
Location:1 → 127

C2A_Munc13; C2 domain first repeat in Munc13 (mammalian uncoordinated) proteins

cd08395
Location:1555 → 1674

C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins

cd00029
Location:563 → 612

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

pfam06292
Location:1003 → 1111

DUF1041; Domain of Unknown Function (DUF1041)

pfam10540
Location:1356 → 1517

Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

72079356..72124418 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017312875.3 → XP_017168364.1 protein unc-13 homolog A isoform X2

Conserved Domains (6) summary

cd04027
Location:690 → 816

C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins

cd08394
Location:1 → 127

C2A_Munc13; C2 domain first repeat in Munc13 (mammalian uncoordinated) proteins

cd08395
Location:1578 → 1697

C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins

cd00029
Location:568 → 617

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

pfam06292
Location:1008 → 1114

DUF1041; Domain of Unknown Function (DUF1041)

pfam10540
Location:1359 → 1521

Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain
XM_030243646.2 → XP_030099506.1 protein unc-13 homolog A isoform X5

Conserved Domains (6) summary

cd04027
Location:675 → 801

C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins

cd08394
Location:1 → 117

C2A_Munc13; C2 domain first repeat in Munc13 (mammalian uncoordinated) proteins

cd08395
Location:1564 → 1683

C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins

cd00029
Location:553 → 602

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

pfam06292
Location:993 → 1099

DUF1041; Domain of Unknown Function (DUF1041)

pfam10540
Location:1345 → 1507

Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain
XM_006509693.5 → XP_006509756.1 protein unc-13 homolog A isoform X4

Conserved Domains (6) summary

cd04027
Location:680 → 806

C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins

cd08394
Location:1 → 117

C2A_Munc13; C2 domain first repeat in Munc13 (mammalian uncoordinated) proteins

cd08395
Location:1569 → 1688

C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins

cd00029
Location:558 → 607

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

pfam06292
Location:998 → 1104

DUF1041; Domain of Unknown Function (DUF1041)

pfam10540
Location:1350 → 1512

Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain
XM_017312883.3 → XP_017168372.1 protein unc-13 homolog A isoform X13

Conserved Domains (6) summary

cd04027
Location:685 → 811

C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins

cd08394
Location:1 → 127

C2A_Munc13; C2 domain first repeat in Munc13 (mammalian uncoordinated) proteins

cd08395
Location:1530 → 1649

C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins

cd00029
Location:563 → 612

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

pfam06292
Location:1003 → 1109

DUF1041; Domain of Unknown Function (DUF1041)

pfam10540
Location:1355 → 1492

Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain
XM_017312882.3 → XP_017168371.1 protein unc-13 homolog A isoform X12

Conserved Domains (6) summary

cd04027
Location:685 → 811

C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins

cd08394
Location:1 → 127

C2A_Munc13; C2 domain first repeat in Munc13 (mammalian uncoordinated) proteins

cd08395
Location:1549 → 1668

C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins

cd00029
Location:563 → 612

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

pfam06292
Location:1003 → 1109

DUF1041; Domain of Unknown Function (DUF1041)

pfam10540
Location:1355 → 1492

Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain
XM_006509692.5 → XP_006509755.1 protein unc-13 homolog A isoform X3

UniProtKB/TrEMBL

H3BJZ7

Related

ENSMUSP00000135189.2, ENSMUST00000177517.8

Conserved Domains (6) summary

cd04027
Location:685 → 811

C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins

cd08394
Location:1 → 127

C2A_Munc13; C2 domain first repeat in Munc13 (mammalian uncoordinated) proteins

cd08395
Location:1574 → 1693

C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins

cd00029
Location:563 → 612

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

pfam06292
Location:1003 → 1109

DUF1041; Domain of Unknown Function (DUF1041)

pfam10540
Location:1355 → 1517

Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain
XM_017312881.3 → XP_017168370.1 protein unc-13 homolog A isoform X10

Conserved Domains (6) summary

cd04027
Location:690 → 816

C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins

cd08394
Location:1 → 127

C2A_Munc13; C2 domain first repeat in Munc13 (mammalian uncoordinated) proteins

cd08395
Location:1535 → 1654

C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins

cd00029
Location:568 → 617

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

pfam06292
Location:1008 → 1114

DUF1041; Domain of Unknown Function (DUF1041)

pfam10540
Location:1360 → 1497

Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain
XM_017312879.3 → XP_017168368.1 protein unc-13 homolog A isoform X8

Conserved Domains (6) summary

cd04027
Location:690 → 816

C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins

cd08394
Location:1 → 127

C2A_Munc13; C2 domain first repeat in Munc13 (mammalian uncoordinated) proteins

cd08395
Location:1554 → 1673

C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins

cd00029
Location:568 → 617

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

pfam06292
Location:1008 → 1114

DUF1041; Domain of Unknown Function (DUF1041)

pfam10540
Location:1360 → 1497

Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain
XM_017312880.3 → XP_017168369.1 protein unc-13 homolog A isoform X9

Conserved Domains (6) summary

cd04027
Location:690 → 816

C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins

cd08394
Location:1 → 127

C2A_Munc13; C2 domain first repeat in Munc13 (mammalian uncoordinated) proteins

cd08395
Location:1537 → 1656

C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins

cd00029
Location:568 → 617

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

pfam06292
Location:1008 → 1114

DUF1041; Domain of Unknown Function (DUF1041)

pfam10540
Location:1360 → 1499

Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain
XM_017312878.3 → XP_017168367.1 protein unc-13 homolog A isoform X7

Conserved Domains (6) summary

cd04027
Location:690 → 816

C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins

cd08394
Location:1 → 127

C2A_Munc13; C2 domain first repeat in Munc13 (mammalian uncoordinated) proteins

cd08395
Location:1556 → 1675

C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins

cd00029
Location:568 → 617

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

pfam06292
Location:1008 → 1114

DUF1041; Domain of Unknown Function (DUF1041)

pfam10540
Location:1360 → 1499

Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain
XM_017312877.3 → XP_017168366.1 protein unc-13 homolog A isoform X6

Conserved Domains (6) summary

cd04027
Location:690 → 816

C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins

cd08394
Location:1 → 127

C2A_Munc13; C2 domain first repeat in Munc13 (mammalian uncoordinated) proteins

cd08395
Location:1560 → 1679

C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins

cd00029
Location:568 → 617

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

pfam06292
Location:1008 → 1114

DUF1041; Domain of Unknown Function (DUF1041)

pfam10540
Location:1360 → 1522

Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain
XM_017312874.3 → XP_017168363.1 protein unc-13 homolog A isoform X1

Conserved Domains (6) summary

cd04027
Location:690 → 816

C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins

cd08394
Location:1 → 127

C2A_Munc13; C2 domain first repeat in Munc13 (mammalian uncoordinated) proteins

cd08395
Location:1579 → 1698

C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins

cd00029
Location:568 → 617

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

pfam06292
Location:1008 → 1114

DUF1041; Domain of Unknown Function (DUF1041)

pfam10540
Location:1360 → 1522

Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain
XM_036154142.1 → XP_036010035.1 protein unc-13 homolog A isoform X11

Conserved Domains (5) summary

cd04027
Location:444 → 570

C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins

cd08395
Location:1333 → 1452

C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins

pfam06292
Location:762 → 870

DUF1041; Domain of Unknown Function (DUF1041)

pfam10540
Location:1114 → 1276

Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain

cd20859
Location:303 → 384

C1_Munc13-2-like; protein kinase C conserved region 1 (C1 domain) found in Munc13-2, Munc13-3 and similar proteins