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    Nyap1 neuronal tyrosine-phosphorylated phosphoinositide 3-kinase adaptor 1 [ Mus musculus (house mouse) ]

    Gene ID: 243300, updated on 12-May-2024

    Summary

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    Official Symbol
    Nyap1provided by MGI
    Official Full Name
    neuronal tyrosine-phosphorylated phosphoinositide 3-kinase adaptor 1provided by MGI
    Primary source
    MGI:MGI:2443880
    See related
    Ensembl:ENSMUSG00000045348 AllianceGenome:MGI:2443880
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    6430598A04Rik
    Summary
    Involved in neuron projection morphogenesis and phosphatidylinositol 3-kinase signaling. Is expressed in central nervous system; neural retina; nucleus pulposus; and spinal ganglion. Orthologous to human NYAP1 (neuronal tyrosine phosphorylated phosphoinositide-3-kinase adaptor 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in whole brain E14.5 (RPKM 38.4), CNS E18 (RPKM 37.3) and 12 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nyap1 in Genome Data Viewer
    Location:
    5 G2; 5 76.62 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (137729144..137739430, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (137730882..137741168, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene 15498 Neighboring gene predicted gene, 54308 Neighboring gene Sp110 nuclear body protein, pseudogene 2 Neighboring gene Tsc22 domain family, member 4 Neighboring gene predicted gene, 57848 Neighboring gene sperm acrosome developmental regulator

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Nyap1 Regulates Multipolar-Bipolar Transition and Morphology of Migrating Neurons by Fyn Phosphorylation during Corticogenesis. Wang S, et al. Cereb Cortex, 2020 Mar 14. PMID 31609430
    2. The netrin-G1 ligand NGL-1 promotes the outgrowth of thalamocortical axons. Lin JC, et al. Nat Neurosci, 2003 Dec. PMID 14595443
    3. NYAP: a phosphoprotein family that links PI3K to WAVE1 signalling in neurons. Yokoyama K, et al. EMBO J, 2011 Sep 23. PMID 21946561, Free PMC Article
    4. Notch signaling is a novel regulator of visceral smooth muscle cell differentiation in the murine ureter. Kurz J, et al. Development, 2022 Feb 15. PMID 35103284
    5. The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis. Menon S, et al. Mol Biol Cell, 2021 Feb 15. PMID 33378226, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in neuron projection morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuron projection morphogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1
    Names
    neuronal tyrosine phosphorylated adaptor for phosphoinositide 3-kinase adaptor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347505.1 → NP_001334434.1  neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.
      Source sequence(s)
      AC124730, AC125063
      Consensus CDS
      CCDS84980.1
      UniProtKB/TrEMBL
      E9PXJ0
      Related
      ENSMUSP00000148318.2, ENSMUST00000212152.2
      Conserved Domains (2) summary
      pfam15439
      Location:4 → 413
      NYAP_N; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter
      pfam15452
      Location:577 → 832
      NYAP_C; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter

    2. NM_175521.4 → NP_780730.2  neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1 isoform 1

      See identical proteins and their annotated locations for NP_780730.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK032567, BC057372, CJ292493
      Consensus CDS
      CCDS19775.1
      UniProtKB/Swiss-Prot
      E1CB66, Q3UF51, Q6PFX7, Q8BNR4, Q8CCL6
      UniProtKB/TrEMBL
      E9PXJ0
      Related
      ENSMUSP00000113397.2, ENSMUST00000118326.8
      Conserved Domains (2) summary
      pfam15439
      Location:15 → 410
      NYAP_N; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter
      pfam15452
      Location:571 → 833
      NYAP_C; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      137729144..137739430 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504576.5 → XP_006504639.1  neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1 isoform X1

      See identical proteins and their annotated locations for XP_006504639.1

      UniProtKB/TrEMBL
      E9PXJ0
      Conserved Domains (2) summary
      pfam15439
      Location:4 → 413
      NYAP_N; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter
      pfam15452
      Location:577 → 832
      NYAP_C; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter

    2. XM_006504577.5 → XP_006504640.1  neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1 isoform X1

      See identical proteins and their annotated locations for XP_006504640.1

      UniProtKB/TrEMBL
      E9PXJ0
      Conserved Domains (2) summary
      pfam15439
      Location:4 → 413
      NYAP_N; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter
      pfam15452
      Location:577 → 832
      NYAP_C; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PFX7.1 GenPept UniProtKB/Swiss-Prot:Q6PFX7

    Gene LinkOut

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