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    Clec2e C-type lectin domain family 2, member e [ Mus musculus (house mouse) ]

    Gene ID: 232409, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Clec2eprovided by MGI
    Official Full Name
    C-type lectin domain family 2, member eprovided by MGI
    Primary source
    MGI:MGI:3028921
    See related
    Ensembl:ENSMUSG00000030155 AllianceGenome:MGI:3028921
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Clra; clr-a
    Summary
    Predicted to enable natural killer cell lectin-like receptor binding activity. Predicted to be located in cell surface and endoplasmic reticulum. Predicted to be active in external side of plasma membrane. Is expressed in brain; gut; liver lobe; and retina nuclear layer. Orthologous to human CLEC2D (C-type lectin domain family 2 member D). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in large intestine adult (RPKM 12.1), small intestine adult (RPKM 6.6) and 2 other tissues See more
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    Genomic context

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    See Clec2e in Genome Data Viewer
    Location:
    6 F3; 6 63.13 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (129068779..129077866, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (129091816..129100903, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene C-type lectin domain family 2, member f Neighboring gene STARR-seq mESC enhancer starr_17472 Neighboring gene killer cell lectin-like receptor subfamily B member 1F Neighboring gene STARR-seq mESC enhancer starr_17473 Neighboring gene STARR-seq mESC enhancer starr_17475 Neighboring gene killer cell lectin-like receptor subfamily B member 1, pseudogene 1 Neighboring gene predicted gene, 53342 Neighboring gene STARR-seq mESC enhancer starr_17476 Neighboring gene predicted gene, 26160

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Microbiota Inhibit Epithelial Pathogen Adherence by Epigenetically Regulating C-Type Lectin Expression. Woo V, et al. Front Immunol, 2019. PMID 31134059, Free PMC Article
    2. Molecular and genetic basis for strain-dependent NK1.1 alloreactivity of mouse NK cells. Carlyle JR, et al. J Immunol, 2006 Jun 15. PMID 16751398
    3. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Microbiota Inhibit Epithelial Pathogen Adherence by Epigenetically Regulating C-Type Lectin Expression.
      Title: Microbiota Inhibit Epithelial Pathogen Adherence by Epigenetically Regulating C-Type Lectin Expression.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables natural killer cell lectin-like receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    C-type lectin domain family 2 member E
    Names
    C-type lectin-related protein A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153506.4 → NP_705726.3  C-type lectin domain family 2 member E

      Status: VALIDATED

      Source sequence(s)
      AC174446
      Consensus CDS
      CCDS39656.1
      UniProtKB/TrEMBL
      H7BWZ4, I3QI44
      Related
      ENSMUSP00000032258.7, ENSMUST00000032258.8
      Conserved Domains (2) summary
      cd03593
      Location:89 → 201
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
      PHA03097
      Location:42 → 199
      PHA03097; C-type lectin-like protein; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      129068779..129077866 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80XD9.2 GenPept UniProtKB/Swiss-Prot:Q80XD9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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