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    TLR9 toll like receptor 9 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 574395, updated on 9-Nov-2023

    Summary

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    Gene symbol
    TLR9
    Gene description
    toll like receptor 9
    See related
    Ensembl:ENSMMUG00000012263 Ensembl:ENSMMUG00000047685
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
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    Genomic context

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    See TLR9 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 2 NC_041755.1 (108361487..108379379, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 2 NC_027894.1 (90000878..90003974)

    Chromosome 2 - NC_041755.1Genomic Context describing neighboring genes Neighboring gene fructose-bisphosphate aldolase A-like Neighboring gene 5'-aminolevulinate synthase 1 Neighboring gene uncharacterized LOC114676359 Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent 1M Neighboring gene WD repeat domain 82 Neighboring gene microRNA let-7g

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Whole blood stimulation with Toll-like receptor (TLR)-7/8 and TLR-9 agonists induces interleukin-12p40 expression in plasmacytoid dendritic cells in rhesus macaques but not in humans. Koopman G, et al. Clin Exp Immunol, 2013 Oct. PMID 23750720, Free PMC Article
    2. Human and rhesus plasmacytoid dendritic cell and B-cell responses to Toll-like receptor stimulation. Gujer C, et al. Immunology, 2011 Nov. PMID 21977996, Free PMC Article
    3. Genetic analysis of Toll/Interleukin-1 Receptor (TIR) domain sequences from rhesus macaque Toll-like receptors (TLRs) 1-10 reveals high homology to human TLR/TIR sequences. Sanghavi SK, et al. Immunogenetics, 2004 Dec. PMID 15578265
    4. Divergent TLR7 and TLR9 signaling and type I interferon production distinguish pathogenic and nonpathogenic AIDS virus infections. Mandl JN, et al. Nat Med, 2008 Oct. PMID 18806803
    5. Natural selection in the TLR-related genes in the course of primate evolution. Nakajima T, et al. Immunogenetics, 2008 Dec. PMID 18810425

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In contrast to humans, plasmacytoid dendritic cells in rhesus macaques express the interleukin (IL)-12p40 subunit in response to TLR-7/8 as well as TLR-9 agonist stimulation.
      Title: Whole blood stimulation with Toll-like receptor (TLR)-7/8 and TLR-9 agonists induces interleukin-12p40 expression in plasmacytoid dendritic cells in rhesus macaques but not in humans.
    2. Data suggest that the response pattern of human and rhesus B cells and pDCs to TLR7/8 and TLR9 is similar, although some differences in the cell surface phenotype of the differentiating cells exist.
      Title: Human and rhesus plasmacytoid dendritic cell and B-cell responses to Toll-like receptor stimulation.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables actin monomer binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables pattern recognition receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin filament depolymerization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in barbed-end actin filament capping IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in defense response to virus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of NF-kappaB transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of interleukin-6 production IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of neuron projection development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of lamellipodium assembly IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in sequestering of actin monomers IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in toll-like receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in actin filament IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in myofibril IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    toll-like receptor 9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130431.2 → NP_001123903.1  toll-like receptor 9 precursor

      See identical proteins and their annotated locations for NP_001123903.1

      Status: VALIDATED

      Source sequence(s)
      EU204947, QNVO02000283
      UniProtKB/TrEMBL
      A0A5K1UUW9, B3Y667, F6UZJ0
      Related
      ENSMMUP00000016086.4, ENSMMUT00000017176.4
      Conserved Domains (5) summary
      PLN00113
      Location:65 → 588
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      sd00033
      Location:476 → 497
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:701 → 762
      LRR_8; Leucine rich repeat
      cl23749
      Location:870 → 1009
      TIR_2; TIR domain
      cl42388
      Location:599 → 777
      PPP1R42; protein phosphatase 1 regulatory subunit 42

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041755.1 Reference Mmul_10 Primary Assembly

      Range
      108361487..108379379 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028843050.1 → XP_028698883.1  toll-like receptor 9 isoform X2

      Conserved Domains (6) summary
      PRK15370
      Location:317 → 533
      PRK15370; E3 ubiquitin-protein ligase SlrP; Provisional
      cd11284
      Location:176 → 294
      ADF_Twf-C_like; C-terminal ADF domain of twinfilin and related proteins
      cd11285
      Location:4 → 142
      ADF_Twf-N_like; N-terminal ADF domain of twinfilin and related proteins
      PLN00113
      Location:493 → 1036
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      sd00033
      Location:769 → 790
      LRR_RI; leucine-rich repeat [structural motif]
      cl23749
      Location:1163 → 1302
      TIR_2; TIR domain

    2. XM_028843049.1 → XP_028698882.1  toll-like receptor 9 isoform X1

      UniProtKB/TrEMBL
      F6UZG1
      Related
      ENSMMUP00000016089.2, ENSMMUT00000017179.4
      Conserved Domains (2) summary
      cd11284
      Location:176 → 311
      ADF_Twf-C_like; C-terminal ADF domain of twinfilin and related proteins
      cd11285
      Location:4 → 142
      ADF_Twf-N_like; N-terminal ADF domain of twinfilin and related proteins
    Nucleotide Protein
    Heading Accession and Version

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