ZNF32 zinc finger protein 32 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ZNF32provided by HGNC
Official Full Name: zinc finger protein 32provided by HGNC
Primary source: HGNC:HGNC:13095
See related: Ensembl:ENSG00000169740 MIM:194539; AllianceGenome:HGNC:13095
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: KOX30; ZNF637; Zfp637
Summary: Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in ovary (RPKM 6.7), thyroid (RPKM 6.7) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 10q11.21

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	10	NC_000010.11 (43643862..43648881, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	10	NC_060934.1 (44524781..44529800, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	10	NC_000010.10 (44139310..44144329, complement)

Chromosome 10 - NC_000010.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ZNF32 prevents the activation of cancer-associated fibroblasts through negative regulation of TGFB1 transcription in breast cancer.
Title: ZNF32 prevents the activation of cancer-associated fibroblasts through negative regulation of TGFB1 transcription in breast cancer.
ZNF32 promotes the self-renewal of colorectal cancer cells by regulating the LEPR-STAT3 signaling pathway.
Title: ZNF32 promotes the self-renewal of colorectal cancer cells by regulating the LEPR-STAT3 signaling pathway.
We conclude that ZNF32 can engage GPER/ERK signalling and confer breast cancer stem cell-like properties, which may indicate poor prognosis of breast cancer patients. ZNF32 and GPER targeted therapies might provide new solutions for breast cancer treatment.
Title: Zinc finger protein 32 promotes breast cancer stem cell-like properties through directly promoting GPER transcription.
ZNF32 contributes to anoikis resistance by maintaining redox homeostasis and activating Src/FAK signaling in HepG2 cells.
Title: ZNF32 induces anoikis resistance through maintaining redox homeostasis and activating Src/FAK signaling in hepatocellular carcinoma.
ZNF32 was found to directly bind to the TGF-betaR2 (transforming growth factor-beta receptor 2) promoter to promote its expression.
Title: ZNF32 contributes to the induction of multidrug resistance by regulating TGF-β receptor 2 signaling in lung adenocarcinoma.
Sp1-ZNF32-C1QBP axis protects against oxidative stress/apoptosis in hepatocellular carcinoma cells.
Title: ZNF32 protects against oxidative stress-induced apoptosis by modulating C1QBP transcription.
ZNF32 acts as an effective autophagy inhibitor to protect breast cancer cells from excessive stimulus-autophagy-induced cell death.
Title: ZNF32 inhibits autophagy through the mTOR pathway and protects MCF-7 cells from stimulus-induced cell death.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH11338 (e-PCR)
- UniSTS:21851

D10S2374 (e-PCR)
- UniSTS:59771

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: zinc finger protein 32

Names: C2H2-546; zinc finger protein 32 (KOX 30); zinc finger protein KOX30

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001005368.3 → NP_001005368.1 zinc finger protein 32 isoform a

See identical proteins and their annotated locations for NP_001005368.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).

Source sequence(s)

BC022842, HY045180

Consensus CDS

CCDS7206.1

UniProtKB/Swiss-Prot

P17041, Q92951

Related

ENSP00000379143.1, ENST00000395797.1

Conserved Domains (2) summary

COG5048
Location:47 → 237

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:79 → 99

ZF_C2H2; C2H2 Zn finger [structural motif]
NM_001324164.2 → NP_001311093.1 zinc finger protein 32 isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (3) and variant 4 both encode the same isoform (b).

Source sequence(s)

AL645634

Conserved Domains (2) summary

COG5048
Location:51 → 241

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:83 → 103

ZF_C2H2; C2H2 Zn finger [structural motif]
NM_001324165.2 → NP_001311094.1 zinc finger protein 32 isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (4) and variant 3 both encode the same isoform (b).

Source sequence(s)

BC022842, HY045180, HY148951

UniProtKB/Swiss-Prot

P17041

Conserved Domains (2) summary

COG5048
Location:51 → 241

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:83 → 103

ZF_C2H2; C2H2 Zn finger [structural motif]
NM_001324166.2 → NP_001311095.1 zinc finger protein 32 isoform c

Status: VALIDATED

Description

Transcript Variant: This variant (5), as well as variants 6 and 7, encodes isoform c.

Source sequence(s)

AL645634

Conserved Domains (2) summary

COG5048
Location:22 → 212

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:54 → 74

ZF_C2H2; C2H2 Zn finger [structural motif]
NM_001324167.2 → NP_001311096.1 zinc finger protein 32 isoform c

Status: VALIDATED

Description

Transcript Variant: This variant (6), as well as variants 5 and 7, encodes isoform c.

Source sequence(s)

AL645634

Conserved Domains (2) summary

COG5048
Location:22 → 212

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:54 → 74

ZF_C2H2; C2H2 Zn finger [structural motif]
NM_001324168.2 → NP_001311097.1 zinc finger protein 32 isoform c

Status: VALIDATED

Description

Transcript Variant: This variant (7), as well as variants 5 and 6, encodes isoform c.

Source sequence(s)

BC022842, HY045180

UniProtKB/Swiss-Prot

P17041

Conserved Domains (2) summary

COG5048
Location:22 → 212

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:54 → 74

ZF_C2H2; C2H2 Zn finger [structural motif]
NM_006973.3 → NP_008904.1 zinc finger protein 32 isoform a

See identical proteins and their annotated locations for NP_008904.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the more frequently occurring variant. Variants 1 and 2 both encode the same isoform (a).

Source sequence(s)

AL645634, BC022842, BG477527

Consensus CDS

CCDS7206.1

UniProtKB/Swiss-Prot

P17041, Q92951

Related

ENSP00000363556.2, ENST00000374433.7

Conserved Domains (2) summary

COG5048
Location:47 → 237

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:79 → 99

ZF_C2H2; C2H2 Zn finger [structural motif]