Cdhr2 cadherin-related family member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cdhr2provided by MGI
Official Full Name: cadherin-related family member 2provided by MGI
Primary source: MGI:MGI:2687323
See related: Ensembl:ENSMUSG00000034918 AllianceGenome:MGI:2687323
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm624; PC-LKC; Pcdh24
Summary: Predicted to enable cell adhesion molecule binding activity. Predicted to be involved in several processes, including cell-cell adhesion mediated by cadherin; intermicrovillar adhesion; and negative regulation of cell growth involved in contact inhibition. Predicted to act upstream of or within cell differentiation. Predicted to be located in apical plasma membrane; brush border membrane; and microvillus membrane. Predicted to be spanning component of plasma membrane. Predicted to be integral component of plasma membrane. Orthologous to human CDHR2 (cadherin related family member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in small intestine adult (RPKM 326.0), duodenum adult (RPKM 242.2) and 3 other tissues See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 13 B1; 13 29.03 cM

Exon count:: 32

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (54849276..54884475)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (54701463..54736662)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CDHR2 functions to elongate microvilli and maximize their numbers on the apical surface, which together serve to increase the functional capacity of enterocyte.
Title: Brush border protocadherin CDHR2 promotes the elongation and maximized packing of microvilli in vivo.

Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1) 1 citation
Targeted (2) 1 citation

General gene information

Go to the top of the page Help

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables cell adhesion molecule binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in brush border assembly	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cell-cell adhesion mediated by cadherin	ISO Inferred from Sequence Orthology more info
involved_in epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IEA Inferred from Electronic Annotation more info
involved_in intermicrovillar adhesion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell growth involved in contact inhibition	ISO Inferred from Sequence Orthology more info
involved_in regulation of microvillus length	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in brush border	ISO Inferred from Sequence Orthology more info
located_in brush border membrane	ISO Inferred from Sequence Orthology more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in microvillus	ISO Inferred from Sequence Orthology more info
located_in microvillus membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: cadherin-related family member 2

Names: protocadherin 24; protocadherin LKC

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033364.3 → NP_001028536.2 cadherin-related family member 2 precursor

Status: VALIDATED

Source sequence(s)

AK144400, BC141301, BX630481

Consensus CDS

CCDS36669.1

UniProtKB/Swiss-Prot

B7ZP46, B9EJ32, E9Q7P9, Q3UN77

Related

ENSMUSP00000043596.8, ENSMUST00000037145.8

Conserved Domains (1) summary

cd11304
Location:485 → 582

Cadherin_repeat; Cadherin tandem repeat domain