PGM5-AS1 PGM5 antisense RNA 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: PGM5-AS1provided by HGNC
Official Full Name: PGM5 antisense RNA 1provided by HGNC
Primary source: HGNC:HGNC:44181
See related: Ensembl:ENSG00000224958 AllianceGenome:HGNC:44181
Gene type: ncRNA
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: FAM233A
Expression: Biased expression in prostate (RPKM 31.6), endometrium (RPKM 17.6) and 4 other tissues See more
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Genomic context

Location:: 9q21.11

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	9	NC_000009.12 (68355164..68357866, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	9	NC_060933.1 (80528761..80531472, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	9	NC_000009.11 (70970080..70972782, complement)

Chromosome 9 - NC_000009.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LncRNA PGM5-AS1 Inhibits the Progression of Bladder Cancer by Regulating miR-587/SLIT3 Axis.
Title: LncRNA PGM5-AS1 Inhibits the Progression of Bladder Cancer by Regulating miR-587/SLIT3 Axis.
Long non-coding RNAs PGM5-AS1 upregulates Decorin (DCN) to inhibit cervical cancer progression by sponging miR-4284.
Title: Long non-coding RNAs PGM5-AS1 upregulates Decorin (DCN) to inhibit cervical cancer progression by sponging miR-4284.
Circulating lncRNA UCA1 and lncRNA PGM5-AS1 act as potential diagnostic biomarkers for early-stage colorectal cancer.
Title: Circulating lncRNA UCA1 and lncRNA PGM5-AS1 act as potential diagnostic biomarkers for early-stage colorectal cancer.
The Downregulation of lncRNA pgm5-as1 Inhibits the Proliferation and Metastasis Via Increasing miR-484 Expression in Colorectal Cancer.
Title: The Downregulation of lncRNA pgm5-as1 Inhibits the Proliferation and Metastasis Via Increasing miR-484 Expression in Colorectal Cancer.
Reduced long noncoding RNA PGM5-AS1 facilitated proliferation and invasion of colorectal cancer through sponging miR-100-5p.
Title: Reduced long noncoding RNA PGM5-AS1 facilitated proliferation and invasion of colorectal cancer through sponging miR-100-5p.
Down-regulation of long noncoding RNA PGM5-AS1 correlates with tumor progression and predicts poor prognosis in clear cell renal cell carcinoma.
Title: Down-regulation of long noncoding RNA PGM5-AS1 correlates with tumor progression and predicts poor prognosis in clear cell renal cell carcinoma.
our data indicate that PGM5-AS1 is a novel tumor suppressor in esophageal squamous cell carcinoma (ESCC) and restoration of PGM5-AS1 may be a promising avenue for treatment of ESCC patient.
Title: p53-induced long non-coding RNA PGM5-AS1 inhibits the progression of esophageal squamous cell carcinoma through regulating miR-466/PTEN axis.
High PGM5-AS1 expression levels were associated with worse overall survival in colorectal cancer.
Title: Identification of key lncRNAs in colorectal cancer progression based on associated protein-protein interaction analysis.
Long non-coding RNA LOC572558 functions as a tumor suppressor and regulates the p53 signaling pathway in bladder cancer.
Title: Long non-coding RNA LOC572558 inhibits bladder cancer cell proliferation and tumor growth by regulating the AKT-MDM2-p53 signaling axis.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

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General gene information

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Other Names

PGM5 antisense RNA 1 (non-protein coding)
family with sequence similarity 233, member A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

NR_015423.2 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate splice site at the 5' terminal exon, resulting in a shorter transcript, compared to variant 1.

Source sequence(s)

AY343894, BC017938, CB051276

Related

ENST00000653382.1
NR_121191.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript.

Source sequence(s)

BC017938, CB051276
NR_121192.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice site at the 5' terminal exon and contains an alternate internal exon, resulting in a shorter transcript, compared to variant 1.

Source sequence(s)

AL353608

Related

ENST00000420855.6