Nlrp2 NLR family, pyrin domain containing 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nlrp2provided by MGI
Official Full Name: NLR family, pyrin domain containing 2provided by MGI
Primary source: MGI:MGI:3041206
See related: Ensembl:ENSMUSG00000035177 AllianceGenome:MGI:3041206
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NBS1; PAN1; Nalp2; PYPAF2; E330007A02Rik
Summary: Predicted to enable several functions, including Pyrin domain binding activity; aspartic-type endopeptidase inhibitor activity; and caspase binding activity. Predicted to be located in Golgi apparatus and cytosol. Predicted to colocalize with chromosome, telomeric region. Is expressed in early conceptus and gonad. Human ortholog(s) of this gene implicated in gestational trophoblastic neoplasm. Orthologous to several human genes including NLRP2 (NLR family pyrin domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: 7 A1; 7 3.07 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (5301546..5354034, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (5298547..5351035, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of the Maternal Effect Gene Nlrp2 Alters the Transcriptome of Ovulated Mouse Oocytes and Impacts Expression of Histone Demethylase KDM1B.
Title: Loss of the Maternal Effect Gene Nlrp2 Alters the Transcriptome of Ovulated Mouse Oocytes and Impacts Expression of Histone Demethylase KDM1B.
Activation of NLRP2 in Triple-Negative Breast Cancer sensitizes chemotherapeutic therapy through facilitating hnRNPK function.
Title: Activation of NLRP2 in Triple-Negative Breast Cancer sensitizes chemotherapeutic therapy through facilitating hnRNPK function.
Reproductive Outcomes from Maternal Loss of Nlrp2 Are Not Improved by IVF or Embryo Transfer Consistent with Oocyte-Specific Defect.
Title: Reproductive Outcomes from Maternal Loss of Nlrp2 Are Not Improved by IVF or Embryo Transfer Consistent with Oocyte-Specific Defect.
Activation of the NLRP2 inflammasome leads to activation of dorsal root ganglion neurons and subsequent development of pain hypersensitivity.
Title: NLRP2 inflammasome in dorsal root ganglion as a novel molecular platform that produces inflammatory pain hypersensitivity.
NLRP2 might be a potential target for developing effective therapeutic strategy to prevent Nonalcoholic fatty liver disease progression.
Title: Suppressing NLRP2 expression accelerates hepatic steatosis: A mechanism involving inflammation and oxidative stress.
Study shownd that apoptosis signal-regulating kinase 1 (ASK1) silencing and ASK1 inhibition reduced ischemic injury-induced nucleotide-binding oligomerization domain-like receptor pyrin domain-containing 2 inflammasomes in the brain and astrocyte cell line, respectively.
Title: Apoptosis Signal-regulating Kinase 1 Silencing on Astroglial Inflammasomes in an Experimental Model of Ischemic Stroke.
female mice lacking NLRP2 are subfertile because of early embryonic loss and the production of fewer offspring that have a wide array of developmental phenotypes and abnormal DNA methylation at imprinted loci.
Title: Maternally expressed NLRP2 links the subcortical maternal complex (SCMC) to fertility, embryogenesis and epigenetic reprogramming.
NLRP2 interacts with FAF1 under normal physiological conditions
Title: NLRP2 and FAF1 deficiency blocks early embryogenesis in the mouse.
This work identifies Nlrp2 as a critical regulator of oocyte quality
Title: NLRP2 controls age-associated maternal fertility.
high expression of NLRP2, especially in astrocytes, may play important roles in the pathophysiological process of ischemic stroke and has potential clinical value for the treatment of ischemic stroke.
Title: NLRP2 is highly expressed in a mouse model of ischemic stroke.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation
Targeted (4) 1 citation

General gene information

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Markers

Nlrp2 (e-PCR), detects polymorphism
- UniSTS:516674

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables Pyrin domain binding	ISO Inferred from Sequence Orthology more info
enables aspartic-type endopeptidase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables caspase binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables interleukin-1 binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in regulation of inflammatory response	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
colocalizes_with chromosome, telomeric region	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: NACHT, LRR and PYD domains-containing protein 2

Names: NACHT, leucine rich repeat and PYD containing 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_177690.3 → NP_808358.2 NACHT, LRR and PYD domains-containing protein 2

See identical proteins and their annotated locations for NP_808358.2

Status: VALIDATED

Source sequence(s)

AC155171, DQ066881

Consensus CDS

CCDS39746.1

UniProtKB/TrEMBL

Q4PLS0

Related

ENSMUSP00000045077.8, ENSMUST00000045022.9

Conserved Domains (4) summary

cd00116
Location:769 → 1008

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

cd08320
Location:11 → 94

Pyrin_NALPs; Pyrin death domain found in NALP proteins

sd00033
Location:743 → 766

LRR_RI; leucine-rich repeat [structural motif]

cl21455
Location:182 → 345

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases