Vill villin-like [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Villprovided by MGI
Official Full Name: villin-likeprovided by MGI
Primary source: MGI:MGI:1201781
See related: Ensembl:ENSMUSG00000038775 AllianceGenome:MGI:1201781
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Villp
Summary: Predicted to enable actin filament binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in actin filament severing; actin polymerization or depolymerization; and barbed-end actin filament capping. Predicted to act upstream of or within actin filament capping. Predicted to be active in actin cytoskeleton and cytoplasm. Is expressed in several structures, including alimentary system; metanephros; nervous system; sensory organ; and skeleton. Orthologous to human VILL (villin like). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in stomach adult (RPKM 30.1), kidney adult (RPKM 10.4) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 F3; 9 71.32 cM

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (118881797..118900593)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (119052729..119071525)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

H. pylori induction of villin in the stomach correlates with activation and cooperative binding of Elk-1 and the SRF to the proximal promoter of villin
Title: Helicobacter-induced intestinal metaplasia in the stomach correlates with Elk-1 and serum response factor induction of villin.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW212592 (e-PCR)
- UniSTS:179990

RH126779 (e-PCR)
- UniSTS:208465

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-4,5-bisphosphate binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within actin filament capping	IEA Inferred from Electronic Annotation more info
involved_in actin filament severing	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin polymerization or depolymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in barbed-end actin filament capping	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytoskeleton organization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: villin-like protein

Names: EF-6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001164567.1 → NP_001158039.1 villin-like protein isoform 1

See identical proteins and their annotated locations for NP_001158039.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).

Source sequence(s)

AK028229, AK166823, BQ833192, CF171710, CN670511

Consensus CDS

CCDS52962.1

UniProtKB/Swiss-Prot

P97809, Q8BIS5, Q8R211, Q8VDI8, Q91YD6

UniProtKB/TrEMBL

G5E8C6

Related

ENSMUSP00000061731.7, ENSMUST00000051386.13

Conserved Domains (7) summary

cd11288
Location:508 → 596

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11289
Location:136 → 229

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11291
Location:611 → 707

gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins

cd11292
Location:249 → 345

gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

cd11293
Location:385 → 485

gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

cl02491
Location:824 → 844

VHP; Villin headpiece domain

cl15697
Location:16 → 121

ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
NM_011700.2 → NP_035830.2 villin-like protein isoform 2

See identical proteins and their annotated locations for NP_035830.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate exon and uses a different splice site in the 3' coding region, compared to variant 1. The resulting protein (isoform 2) has a shorter C-terminus when compared to isoform 1.

Source sequence(s)

AK028229, AK166652, AK166823, BB611096, CN670511

Consensus CDS

CCDS23606.1

UniProtKB/Swiss-Prot

P97809, Q8BIS5, Q8R211, Q8VDI8, Q91YD6

UniProtKB/TrEMBL

G5E8H0

Related

ENSMUSP00000074294.7, ENSMUST00000074734.13

Conserved Domains (6) summary

cd11288
Location:508 → 596

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11289
Location:136 → 229

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11292
Location:249 → 345

gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

cd11293
Location:385 → 485

gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

cl02491
Location:740 → 760

VHP; Villin headpiece domain

cl15697
Location:16 → 121

ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

118881797..118900593

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006512061.2 → XP_006512124.1 villin-like protein isoform X2

UniProtKB/Swiss-Prot

P97809, Q8BIS5, Q8R211, Q8VDI8, Q91YD6

Conserved Domains (7) summary

cd11288
Location:508 → 596

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11289
Location:136 → 229

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11291
Location:611 → 713

gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins

cd11292
Location:249 → 345

gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

cd11293
Location:385 → 485

gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

pfam02209
Location:808 → 828

VHP; Villin headpiece domain

cl15697
Location:16 → 121

ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
XM_006512062.2 → XP_006512125.1 villin-like protein isoform X3

UniProtKB/Swiss-Prot

P97809, Q8BIS5, Q8R211, Q8VDI8, Q91YD6

Conserved Domains (7) summary

cd11288
Location:508 → 596

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11289
Location:136 → 229

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11291
Location:611 → 707

gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins

cd11292
Location:249 → 345

gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

cd11293
Location:385 → 485

gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

pfam02209
Location:802 → 822

VHP; Villin headpiece domain

cl15697
Location:16 → 121

ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
XM_006512059.4 → XP_006512122.1 villin-like protein isoform X1

See identical proteins and their annotated locations for XP_006512122.1

UniProtKB/Swiss-Prot

P97809, Q8BIS5, Q8R211, Q8VDI8, Q91YD6

Conserved Domains (7) summary

cd11288
Location:508 → 596

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11289
Location:136 → 229

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11291
Location:611 → 713

gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins

cd11292
Location:249 → 345

gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

cd11293
Location:385 → 485

gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

pfam02209
Location:830 → 850

VHP; Villin headpiece domain

cl15697
Location:16 → 121

ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
XM_006512063.4 → XP_006512126.1 villin-like protein isoform X4

UniProtKB/Swiss-Prot

P97809, Q8BIS5, Q8R211, Q8VDI8, Q91YD6

Conserved Domains (6) summary

cd11288
Location:508 → 596

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11289
Location:136 → 229

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11292
Location:249 → 345

gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

cd11293
Location:385 → 485

gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

pfam02209
Location:762 → 782

VHP; Villin headpiece domain

cl15697
Location:16 → 121

ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
XM_006512060.4 → XP_006512123.1 villin-like protein isoform X1

See identical proteins and their annotated locations for XP_006512123.1

UniProtKB/Swiss-Prot

P97809, Q8BIS5, Q8R211, Q8VDI8, Q91YD6

Conserved Domains (7) summary

cd11288
Location:508 → 596

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11289
Location:136 → 229

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11291
Location:611 → 713

gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins

cd11292
Location:249 → 345

gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

cd11293
Location:385 → 485

gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

pfam02209
Location:830 → 850

VHP; Villin headpiece domain

cl15697
Location:16 → 121

ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
XM_006512067.3 → XP_006512130.1 villin-like protein isoform X7

UniProtKB/TrEMBL

D3Z669

Related

ENSMUSP00000116262.2, ENSMUST00000126251.8

Conserved Domains (4) summary

cd11288
Location:116 → 204

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11291
Location:219 → 321

gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins

cd11293
Location:2 → 93

gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

pfam02209
Location:438 → 458

VHP; Villin headpiece domain
XM_006512065.3 → XP_006512128.1 villin-like protein isoform X5

UniProtKB/TrEMBL

D3Z669

Related

ENSMUSP00000116546.2, ENSMUST00000141185.8

Conserved Domains (4) summary

cd11288
Location:124 → 212

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11291
Location:227 → 329

gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins

cd11293
Location:1 → 101

gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

pfam02209
Location:446 → 466

VHP; Villin headpiece domain
XM_006512066.5 → XP_006512129.1 villin-like protein isoform X6

UniProtKB/TrEMBL

D3Z669

Conserved Domains (4) summary

cd11288
Location:124 → 212

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11291
Location:227 → 329

gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins

cd11293
Location:7 → 101

gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

pfam02209
Location:446 → 466

VHP; Villin headpiece domain