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    Zfp324 zinc finger protein 324 [ Mus musculus (house mouse) ]

    Gene ID: 243834, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Zfp324provided by MGI
    Official Full Name
    zinc finger protein 324provided by MGI
    Primary source
    MGI:MGI:2444641
    See related
    Ensembl:ENSMUSG00000004500 AllianceGenome:MGI:2444641
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ZF5128; A930002M05; D430030K24Rik
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in 1st branchial arch maxillary component; early conceptus; genitourinary system; and heart. Orthologous to several human genes including ZNF324 (zinc finger protein 324). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in ovary adult (RPKM 6.1), adrenal adult (RPKM 3.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp324 in Genome Data Viewer
    Location:
    7 A1; 7 7.71 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (12699765..12707749)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (12965838..12974244)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene ring finger protein 225 Neighboring gene predicted gene, 26325 Neighboring gene RIKEN cDNA 1810019N24 gene Neighboring gene STARR-seq mESC enhancer starr_18063 Neighboring gene predicted gene 29638 Neighboring gene zinc finger protein 446 Neighboring gene solute carrier family 27 (fatty acid transporter), member 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
    2. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
    3. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    4. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 324A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362139.1 → NP_001349068.1  zinc finger protein 324A isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK054407, AK152107, BC053093
      UniProtKB/TrEMBL
      Q8BW39
      Conserved Domains (3) summary
      COG5048
      Location:69 → 269
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:65 → 85
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:274 → 297
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001362140.1 → NP_001349069.1  zinc finger protein 324A isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK052251, AK054407, AK152107, BC053093
      UniProtKB/TrEMBL
      Q8BW39
      Conserved Domains (3) summary
      COG5048
      Location:69 → 269
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:65 → 85
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:274 → 297
      zf-H2C2_2; Zinc-finger double domain

    3. NM_178732.4 → NP_848847.3  zinc finger protein 324A isoform 1

      See identical proteins and their annotated locations for NP_848847.3

      Status: VALIDATED

      Source sequence(s)
      AK152107, BC053093
      Consensus CDS
      CCDS20819.1
      UniProtKB/TrEMBL
      Q78F42
      Related
      ENSMUSP00000041944.8, ENSMUST00000038701.8
      Conserved Domains (6) summary
      smart00349
      Location:31 → 91
      KRAB; krueppel associated box
      COG5048
      Location:297 → 497
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:293 → 313
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:403 → 425
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:31 → 70
      KRAB; KRAB box
      pfam13465
      Location:305 → 330
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      12699765..12707749
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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