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    Lrriq1 leucine-rich repeats and IQ motif containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 74978, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Lrriq1provided by MGI
    Official Full Name
    leucine-rich repeats and IQ motif containing 1provided by MGI
    Primary source
    MGI:MGI:1922228
    See related
    Ensembl:ENSMUSG00000019892 AllianceGenome:MGI:1922228
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm1557; 4930503E15Rik
    Summary
    Predicted to enable protein kinase binding activity. Predicted to be active in cytoplasm. Orthologous to human LRRIQ1 (leucine rich repeats and IQ motif containing 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 2.6), whole brain E14.5 (RPKM 0.3) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Lrriq1 in Genome Data Viewer
    Location:
    10 D1; 10 53.65 cM
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (102880238..103072236, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (103044377..103236375, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene 5175 Neighboring gene ALX homeobox 1 Neighboring gene predicted gene, 34298 Neighboring gene predicted gene, 25376 Neighboring gene STARR-seq mESC enhancer starr_27747 Neighboring gene STARR-seq mESC enhancer starr_27748 Neighboring gene STARR-seq mESC enhancer starr_27749 Neighboring gene STARR-seq mESC enhancer starr_27750 Neighboring gene STARR-seq mESC enhancer starr_27751 Neighboring gene RIKEN cDNA 6430590A10 gene Neighboring gene STARR-seq mESC enhancer starr_27752 Neighboring gene solute carrier family 6 (neurotransmitter transporter), member 15 Neighboring gene ribosomal protein L7A pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Lrriq1 is an essential factor for fertility by suppressing apoptosis. Fukutomi M, et al. J Assist Reprod Genet, 2022 Nov. PMID 36129630, Free PMC Article
    2. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Lrriq1 is an essential factor for fertility by suppressing apoptosis.
      Title: Lrriq1 is an essential factor for fertility by suppressing apoptosis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeat and IQ domain-containing protein 1
    Names
    IQ domain-containing protein LRRIQ1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163559.2 → NP_001157031.1  leucine-rich repeat and IQ domain-containing protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001157031.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC122850, AC162918
      Consensus CDS
      CCDS48687.1
      UniProtKB/Swiss-Prot
      Q0P5X1, Q3TYL6, Q9CUK8
      Related
      ENSMUSP00000131419.2, ENSMUST00000166240.8
      Conserved Domains (3) summary
      PTZ00121
      Location:173 → 657
      PTZ00121; MAEBL; Provisional
      sd00033
      Location:833 → 854
      LRR_RI; leucine-rich repeat [structural motif]
      NF033189
      Location:808 → 1056
      internalin_A; class 1 internalin InlA

    2. NM_001361058.1 → NP_001347987.1  leucine-rich repeat and IQ domain-containing protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC122850, AK015687, AK158531, BC051400
      Consensus CDS
      CCDS48686.1
      Conserved Domains (1) summary
      cl26511
      Location:173 → 534
      Neuromodulin_N; Gap junction protein N-terminal region

    3. NM_029134.2 → NP_083410.1  leucine-rich repeat and IQ domain-containing protein 1 isoform 2

      See identical proteins and their annotated locations for NP_083410.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses a distinct 3' CDS and UTR and lacks many 3' coding exons, compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK015687, BC051400
      Consensus CDS
      CCDS48686.1
      UniProtKB/Swiss-Prot
      Q0P5X1
      Related
      ENSMUSP00000020043.6, ENSMUST00000020043.12
      Conserved Domains (1) summary
      cl26511
      Location:173 → 534
      Neuromodulin_N; Gap junction protein N-terminal region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      102880238..103072236 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011243593.2 → XP_011241895.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011241895.1

      Conserved Domains (3) summary
      PTZ00121
      Location:173 → 657
      PTZ00121; MAEBL; Provisional
      sd00033
      Location:833 → 854
      LRR_RI; leucine-rich repeat [structural motif]
      NF033189
      Location:808 → 1056
      internalin_A; class 1 internalin InlA

    2. XM_030245337.1 → XP_030101197.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X6

      Conserved Domains (3) summary
      PTZ00121
      Location:173 → 657
      PTZ00121; MAEBL; Provisional
      sd00033
      Location:833 → 854
      LRR_RI; leucine-rich repeat [structural motif]
      NF033189
      Location:808 → 1056
      internalin_A; class 1 internalin InlA

    3. XM_030245336.1 → XP_030101196.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X5

      Conserved Domains (3) summary
      PTZ00121
      Location:173 → 657
      PTZ00121; MAEBL; Provisional
      sd00033
      Location:833 → 854
      LRR_RI; leucine-rich repeat [structural motif]
      NF033189
      Location:808 → 1056
      internalin_A; class 1 internalin InlA

    4. XM_011243594.2 → XP_011241896.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X2

      Conserved Domains (3) summary
      PTZ00121
      Location:173 → 657
      PTZ00121; MAEBL; Provisional
      sd00033
      Location:833 → 854
      LRR_RI; leucine-rich repeat [structural motif]
      NF033189
      Location:808 → 1056
      internalin_A; class 1 internalin InlA

    5. XM_011243595.2 → XP_011241897.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X4

      Conserved Domains (3) summary
      PTZ00121
      Location:173 → 657
      PTZ00121; MAEBL; Provisional
      sd00033
      Location:833 → 854
      LRR_RI; leucine-rich repeat [structural motif]
      NF033189
      Location:808 → 1056
      internalin_A; class 1 internalin InlA

    6. XM_006514256.2 → XP_006514319.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X3

      Conserved Domains (3) summary
      PTZ00121
      Location:173 → 657
      PTZ00121; MAEBL; Provisional
      sd00033
      Location:833 → 854
      LRR_RI; leucine-rich repeat [structural motif]
      NF033189
      Location:808 → 1056
      internalin_A; class 1 internalin InlA

    7. XM_011243592.2 → XP_011241894.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011241894.1

      Conserved Domains (3) summary
      PTZ00121
      Location:173 → 657
      PTZ00121; MAEBL; Provisional
      sd00033
      Location:833 → 854
      LRR_RI; leucine-rich repeat [structural motif]
      NF033189
      Location:808 → 1056
      internalin_A; class 1 internalin InlA

    8. XM_011243596.1 → XP_011241898.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X11

      Conserved Domains (3) summary
      PTZ00121
      Location:73 → 557
      PTZ00121; MAEBL; Provisional
      sd00033
      Location:733 → 754
      LRR_RI; leucine-rich repeat [structural motif]
      NF033189
      Location:708 → 956
      internalin_A; class 1 internalin InlA

    9. XM_036156065.1 → XP_036011958.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X12

      Conserved Domains (4) summary
      PTZ00121
      Location:1 → 439
      PTZ00121; MAEBL; Provisional
      sd00033
      Location:615 → 636
      LRR_RI; leucine-rich repeat [structural motif]
      NF033189
      Location:482 → 836
      internalin_A; class 1 internalin InlA
      cd21340
      Location:618 → 872
      PPP1R42; protein phosphatase 1 regulatory subunit 42

    10. XM_030245338.2 → XP_030101198.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X8

      Conserved Domains (3) summary
      PTZ00121
      Location:173 → 657
      PTZ00121; MAEBL; Provisional
      sd00033
      Location:833 → 854
      LRR_RI; leucine-rich repeat [structural motif]
      NF033189
      Location:808 → 1056
      internalin_A; class 1 internalin InlA

    11. XM_036156063.1 → XP_036011956.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X7

      Conserved Domains (4) summary
      PTZ00121
      Location:173 → 657
      PTZ00121; MAEBL; Provisional
      sd00033
      Location:833 → 854
      LRR_RI; leucine-rich repeat [structural motif]
      NF033189
      Location:700 → 1054
      internalin_A; class 1 internalin InlA
      cd21340
      Location:836 → 1090
      PPP1R42; protein phosphatase 1 regulatory subunit 42

    12. XM_036156064.1 → XP_036011957.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X10

      Conserved Domains (4) summary
      PTZ00121
      Location:173 → 657
      PTZ00121; MAEBL; Provisional
      sd00033
      Location:833 → 854
      LRR_RI; leucine-rich repeat [structural motif]
      NF033189
      Location:700 → 1054
      internalin_A; class 1 internalin InlA
      cd21340
      Location:836 → 1090
      PPP1R42; protein phosphatase 1 regulatory subunit 42

    13. XM_006514259.3 → XP_006514322.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X9

      See identical proteins and their annotated locations for XP_006514322.1

      UniProtKB/Swiss-Prot
      Q0P5X1, Q3TYL6, Q9CUK8
      Conserved Domains (3) summary
      PTZ00121
      Location:173 → 657
      PTZ00121; MAEBL; Provisional
      sd00033
      Location:833 → 854
      LRR_RI; leucine-rich repeat [structural motif]
      NF033189
      Location:808 → 1056
      internalin_A; class 1 internalin InlA

    RNA

    1. XR_871734.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0P5X1.2 GenPept UniProtKB/Swiss-Prot:Q0P5X1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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