DACT2 dishevelled binding antagonist of beta catenin 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: DACT2provided by HGNC
Official Full Name: dishevelled binding antagonist of beta catenin 2provided by HGNC
Primary source: HGNC:HGNC:21231
See related: Ensembl:ENSG00000164488 MIM:608966; AllianceGenome:HGNC:21231
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: DPR2; DAPPER2; C6orf116; bA503C24.7
Summary: Predicted to enable several functions, including beta-catenin binding activity; delta-catenin binding activity; and protein kinase C binding activity. Predicted to be involved in several processes, including epithelial cell morphogenesis; inner medullary collecting duct development; and negative regulation of nodal signaling pathway. Predicted to act upstream of or within hematopoietic progenitor cell differentiation. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in placenta (RPKM 6.6), prostate (RPKM 2.5) and 8 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 6q27

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	6	NC_000006.12 (168292830..168319777, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	6	NC_060930.1 (169636986..169662545, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	6	NC_000006.11 (168693510..168720457, complement)

Chromosome 6 - NC_000006.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Different expression of DACT1, DACT2, and CYCLIN D1 genes in human colorectal cancer tissues and its association with clinicopathological characteristics.
Title: Different expression of DACT1, DACT2, and CYCLIN D1 genes in human colorectal cancer tissues and its association with clinicopathological characteristics.
Comparative exome sequencing reveals novel candidate genes for retinitis pigmentosa.
Title: Comparative exome sequencing reveals novel candidate genes for retinitis pigmentosa.
An association was found of DACT2 promoter methylation with advanced tumor stages. This gene has been suggested as a potential biomarker, however, more investigation is required to validate this function.
Title: Association between promoter hypermethylation of the DACT2 gene and tumor stages in breast cancer.
Studies suggested that DACT2 expression in nasopharyngeal carcinoma cells is restored by TET1 which demethylates its promotor region.
Title: TET1 exerts its anti-tumor functions via demethylating DACT2 and SFRP2 to antagonize Wnt/β-catenin signaling pathway in nasopharyngeal carcinoma cells.
Results demonstrate that DACT2 is frequently inactivated epigenetically by CpG methylation in nasopharyngeal carcinoma (NPC), while it inhibits NPC cell proliferation and metastasis via suppressing beta-catenin/Cdc25c signaling. These findings suggest that DACT2 promoter methylation is a potential epigenetic biomarker for the detection of NPC.
Title: The new 6q27 tumor suppressor DACT2, frequently silenced by CpG methylation, sensitizes nasopharyngeal cancer cells to paclitaxel and 5-FU toxicity via β-catenin/Cdc25c signaling and G2/M arrest.
Our findings provide a novel DACT2 demethylating stimulator to verify and expand previously established link between DACT2 and colorectal cancer (CRC), suggesting DACT2 demethylation is strongly correlated with CRC prognosis.
Title: DACT2 Epigenetic Stimulator Exerts Dual Efficacy for Colorectal Cancer Prevention and Treatment.
DACT2 suppresses breast cancer cell growth both in vitro and in vivo.
Title: Methylation of DACT2 promotes breast cancer development by activating Wnt signaling.
The rate of methylation of ZIC1, ZIC4, HHIP, and DACT2 in tumors was very high, while methylation of CXXC4 was low to moderate in OSCC and LSCC.
Title: Prognostic significance of the methylation of Wnt pathway antagonists-CXXC4, DACT2, and the inhibitors of sonic hedgehog signaling-ZIC1, ZIC4, and HHIP in head and neck squamous cell carcinomas.
Results demonstrate that DACT2 functions as a tumor suppressor for breast cancer but was frequently disrupted epigenetically in this cancer.
Title: DACT2 silencing by promoter CpG methylation disrupts its regulation of epithelial-to-mesenchymal transition and cytoskeleton reorganization in breast cancer cells.
The simultaneous methylation of DACT1 and DACT2 may play important roles in progression of ESCC and may serve as prognostic methylation biomarkers for ESCC patients.
Title: Aberrant methylation of DACT1 and DACT2 are associated with tumor progression and poor prognosis in esophageal squamous cell carcinoma.

Submit: New GeneRIF Correction See all GeneRIFs (23)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:482635

DACT2_3728 (e-PCR)
- UniSTS:471411

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables beta-catenin binding	ISS Inferred from Sequence or Structural Similarity more info
enables delta-catenin binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein kinase A binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein kinase C binding	ISS Inferred from Sequence or Structural Similarity more info
enables transcription factor binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in epithelial cell morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in hematopoietic progenitor cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in inner medullary collecting duct development	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of nodal signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of nodal signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in skin development	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: dapper homolog 2

Names: dapper antagonist of catenin 2; dapper homolog 2, antagonist of beta-catenin; dapper, antagonist of beta-catenin, homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001286350.2 → NP_001273279.1 dapper homolog 2 isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks a portion of the 5' UTR and 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a.

Source sequence(s)

AF318336, AL606970, BC092498, BC111790, BX377941

Consensus CDS

CCDS75554.1

UniProtKB/Swiss-Prot

Q5SW24

Related

ENSP00000476573.1, ENST00000610183.1

Conserved Domains (1) summary

pfam15268
Location:45 → 604

Dapper; Dapper
NM_001286351.2 → NP_001273280.1 dapper homolog 2 isoform c

Status: VALIDATED

Description

Transcript Variant: This variant (3) contains alternate 3' exon structure and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (c) has a distinct C-terminus and is shorter than isoform a.

Source sequence(s)

AF318336, AL606970, BC092498, BC111790

Consensus CDS

CCDS69241.1

UniProtKB/Swiss-Prot

Q5SW24

Related

ENSP00000355761.2, ENST00000366796.7

Conserved Domains (1) summary

pfam15268
Location:26 → 181

Dapper; Dapper
NM_214462.5 → NP_999627.2 dapper homolog 2 isoform a

See identical proteins and their annotated locations for NP_999627.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).

Source sequence(s)

AF318336, AL606970, BC092498, BC111790, BX377941

Consensus CDS

CCDS47519.1

UniProtKB/Swiss-Prot

Q2NKJ2, Q569G0, Q5SW24, Q8WYW2

Related

ENSP00000355760.3, ENST00000366795.4

Conserved Domains (1) summary

pfam15268
Location:26 → 774

Dapper

RNA

NR_104425.2 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks two internal exons and uses two alternate splice sites, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.

Source sequence(s)

AF318336, AL606970, BC092498, BC111764, BX377941

Related

ENST00000607983.1