uckl1a uridine-cytidine kinase 1-like 1a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: uckl1aprovided by ZNC
Official Full Name: uridine-cytidine kinase 1-like 1aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040724-238
See related: Ensembl:ENSDARG00000001686 AllianceGenome:ZFIN:ZDB-GENE-040724-238
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: uckl1; zK70P6.2; si:dkey-70p6.2
Summary: Predicted to enable ATP binding activity and uridine kinase activity. Predicted to be involved in CTP salvage and UMP salvage. Predicted to act upstream of or within nucleoside metabolic process and phosphorylation. Predicted to be active in cytoplasm. Orthologous to human UCKL1 (uridine-cytidine kinase 1 like 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 8

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (23009662..23029903)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (22988423..23008668)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables uridine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in CTP salvage	IEA Inferred from Electronic Annotation more info
involved_in UMP salvage	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: uridine-cytidine kinase 1-like 1a; uridine-cytidine kinase-like 1a

Names: uridine-cytidine kinase 1-like 1; uridine/cytidine kinase-like 1

NP_001121731.1

EC 2.7.1.48

XP_005167107.1

EC 2.7.1.48

XP_017212851.1

EC 2.7.1.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001128259.1 → NP_001121731.1 uridine-cytidine kinase-like 1a

Status: PROVISIONAL

Source sequence(s)

BX649575

UniProtKB/TrEMBL

A0A8M1NH97, B0S7A4

Related

ENSDARP00000038740.6, ENSDART00000030885.7

Conserved Domains (3) summary

COG0572
Location:79 → 286

Udk; Uridine kinase [Nucleotide transport and metabolism]

cd02023
Location:80 → 279

UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...

pfam14681
Location:309 → 512

UPRTase; Uracil phosphoribosyltransferase

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007119.7 Reference GRCz11 Primary Assembly

Range

23009662..23029903

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005167050.4 → XP_005167107.1 uridine-cytidine kinase 1-like 1a isoform X1

UniProtKB/TrEMBL

A0A8M2BF24

Conserved Domains (3) summary

COG0572
Location:93 → 300

Udk; Uridine kinase [Nucleotide transport and metabolism]

cd02023
Location:94 → 293

UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...

pfam14681
Location:323 → 526

UPRTase; Uracil phosphoribosyltransferase
XM_017357362.2 → XP_017212851.1 uridine-cytidine kinase 1-like 1a isoform X2

UniProtKB/TrEMBL

A0A8M6YZU3