suv39h1a SUV39H1 histone lysine methyltransferase a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: suv39h1aprovided by ZNC
Official Full Name: SUV39H1 histone lysine methyltransferase aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040801-111
See related: Ensembl:ENSDARG00000026799 AllianceGenome:ZFIN:ZDB-GENE-040801-111
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fe02c04; suv39h1; wu:fe02c04; zgc:101027
Summary: Predicted to enable histone methyltransferase activity (H3-K9 specific). Acts upstream of or within exocrine pancreas development; histone H3-K9 methylation; and retina morphogenesis in camera-type eye. Predicted to be located in chromosome, centromeric region. Predicted to be active in nucleus. Is expressed in several structures, including blastomere; digestive system; head; integument; and trunk musculature. Orthologous to several human genes including SUV39H1 (SUV39H1 histone lysine methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 8

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (23395366..23405093)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (23374204..23383866)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The identification of a histone H3 lysine 9 histone methyltransferase, SUV39H1, as a suppressor of embryonal rhabdomyosarcoma formation in zebrafish, is described.
Title: The histone methyltransferase SUV39H1 suppresses embryonal rhabdomyosarcoma formation in zebrafish.
These results suggest that Dnmt1 activity helps direct histone methylation by Suv39h1 and that, together, Dnmt1 and Suv39h1 help guide the terminal differentiation of particular tissues.
Title: Zebra fish Dnmt1 and Suv39h1 regulate organ-specific terminal differentiation during development.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables histone H3K9 methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone H3K9 methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K9 methyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables histone H3K9 monomethyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K9 trimethyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K9me2 methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chromatin remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within exocrine pancreas development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within methylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within retina morphogenesis in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in chromosome, centromeric region	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: histone-lysine N-methyltransferase SUV39H1-A

Names: su(var)3-9 homolog 1-A; suppressor of variegation 3-9 homolog 1; suppressor of variegation 3-9 homolog 1-A; suppressor of variegation 3-9 homolog 1a; suppressor of variegation 3-9-like 1a

NP_001003592.1

EC 2.1.1.366

XP_005167085.1

EC 2.1.1.366

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001003592.1 → NP_001003592.1 histone-lysine N-methyltransferase SUV39H1-A

See identical proteins and their annotated locations for NP_001003592.1

Status: PROVISIONAL

Source sequence(s)

BC076417

UniProtKB/Swiss-Prot

A5XBP4, B0S580, Q6DGD3

Related

ENSDARP00000034818.6, ENSDART00000038955.7

Conserved Domains (3) summary

smart00317
Location:242 → 365

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

pfam00385
Location:44 → 91

Chromo; Chromo (CHRromatin Organization MOdifier) domain

pfam05033
Location:139 → 234

Pre-SET; Pre-SET motif

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007119.7 Reference GRCz11 Primary Assembly

Range

23395366..23405093

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005167028.4 → XP_005167085.1 histone-lysine N-methyltransferase SUV39H1-A isoform X1

UniProtKB/TrEMBL

A0A8M2BEH8

Conserved Domains (3) summary

smart00317
Location:242 → 285

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

pfam00385
Location:44 → 91

Chromo; Chromo (CHRromatin Organization MOdifier) domain

pfam05033
Location:140 → 234

Pre-SET; Pre-SET motif