CCR4 C-C motif chemokine receptor 4 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CCR4provided by HGNC
Official Full Name: C-C motif chemokine receptor 4provided by HGNC
Primary source: HGNC:HGNC:1605
See related: Ensembl:ENSG00000183813 MIM:604836; AllianceGenome:HGNC:1605
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CKR4; K5-5; CD194; CMKBR4; ChemR13; CC-CKR-4; HGCN:14099
Summary: The protein encoded by this gene belongs to the G-protein-coupled receptor family . It is a receptor for the CC chemokine - MIP-1, RANTES, TARC and MCP-1. Chemokines are a group of small polypeptide, structurally related molecules that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. [provided by RefSeq, Jul 2008]
Expression: Biased expression in appendix (RPKM 6.5), urinary bladder (RPKM 6.3) and 12 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 3p22.3

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	3	NC_000003.12 (32951644..32956349)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	3	NC_060927.1 (32953438..32958143)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	3	NC_000003.11 (32993136..32997841)

Chromosome 3 - NC_000003.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CCR4-NOT differentially controls host versus virus poly(a)-tail length and regulates HCMV infection.
Title: CCR4-NOT differentially controls host versus virus poly(a)-tail length and regulates HCMV infection.
Blockade of CCR4 breaks immune tolerance in chronic hepatitis B patients by modulating regulatory pathways.
Title: Blockade of CCR4 breaks immune tolerance in chronic hepatitis B patients by modulating regulatory pathways.
Contributions of Ccr4 and Gcn2 to the Translational Response of C. neoformans to Host-Relevant Stressors and Integrated Stress Response Induction.
Title: Contributions of Ccr4 and Gcn2 to the Translational Response of C. neoformans to Host-Relevant Stressors and Integrated Stress Response Induction.
FOXP3/HAT1 Axis Controls Treg Infiltration in the Tumor Microenvironment by Inducing CCR4 Expression in Breast Cancer.
Title: FOXP3/HAT1 Axis Controls Treg Infiltration in the Tumor Microenvironment by Inducing CCR4 Expression in Breast Cancer.
Targeting CCL2-CCR4 axis suppress cell migration of head and neck squamous cell carcinoma.
Title: Targeting CCL2-CCR4 axis suppress cell migration of head and neck squamous cell carcinoma.
RNF219 attenuates global mRNA decay through inhibition of CCR4-NOT complex-mediated deadenylation.
Title: RNF219 attenuates global mRNA decay through inhibition of CCR4-NOT complex-mediated deadenylation.
Immune signature of CCR7(+) central memory T cells associates with disease severity and Immunoglobulin E in bronchial asthma.
Title: Immune signature of CCR7(+) central memory T cells associates with disease severity and Immunoglobulin E in bronchial asthma.
Tumors establish resistance to immunotherapy by regulating Treg recruitment via CCR4.
Title: Tumors establish resistance to immunotherapy by regulating T(reg) recruitment via CCR4.
Identification of Phosphorylated Amino Acids in Human TNRC6A C-Terminal Region and Their Effects on the Interaction with the CCR4-NOT Complex.
Title: Identification of Phosphorylated Amino Acids in Human TNRC6A C-Terminal Region and Their Effects on the Interaction with the CCR4-NOT Complex.
MiR-532-5p Suppresses Migration and Invasion of Lung Cancer Cells Through Inhibiting CCR4.
Title: MiR-532-5p Suppresses Migration and Invasion of Lung Cancer Cells Through Inhibiting CCR4.

Submit: New GeneRIF Correction See all GeneRIFs (92)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Multiple common variants for celiac disease influencing immune gene expression. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	An envelope-mediated fusion assay demonstrates low HIV-1 gp120 use of CCR4 as a coreceptor for some primary HIV-1 isolates; treatment of PBMC with CCL22 causes down-modulation of endogenous CCR4 but has no significant effect on HIV-1 entry	PubMed
Tat	tat	CCR4 is upregulated by HIV-1 Tat treatment in human epithelial cells	PubMed
Vif	vif	HIV-1 Vif upregulates the expression of chemokine (C-C motif) receptor 4 (CCR4) in Vif-expression T cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D8S2279 (e-PCR)
- UniSTS:473907

D3S4501 (e-PCR)
- UniSTS:474433

CCR4_517 (e-PCR)
- UniSTS:277064

L17796 (e-PCR)
- UniSTS:12896

L17709 (e-PCR)
- UniSTS:42599

RH91673 (e-PCR)
- UniSTS:87663

NoName (e-PCR)
- UniSTS:482160

SHGC-76800 (e-PCR)
- UniSTS:72360

G29868 (e-PCR)
- UniSTS:74164

PMC135988P7 (e-PCR)
- UniSTS:270793

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables C-C chemokine binding	IBA Inferred from Biological aspect of Ancestor more info
enables C-C chemokine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables chemokine receptor activity	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in calcium-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in chemokine-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in chemotaxis	TAS Traceable Author Statement more info	PubMed
involved_in homeostasis of number of cells	IEA Inferred from Electronic Annotation more info
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in interneuron migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of positive chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in response to bacterium	IEA Inferred from Electronic Annotation more info
involved_in tolerance induction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: C-C chemokine receptor type 4

Names: C-C CKR-4; CCR-4; chemokine (C-C motif) receptor 4; chemokine (C-C) receptor 4

NP_005499.1

EC 3.1.13.4

XP_016861176.1

EC 3.1.13.4

XP_054201145.1

EC 3.1.13.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_005508.5 → NP_005499.1 C-C chemokine receptor type 4

See identical proteins and their annotated locations for NP_005499.1

Status: REVIEWED

Source sequence(s)

AC137560, BC071751

Consensus CDS

CCDS2656.1

UniProtKB/Swiss-Prot

P51679, Q9ULY6, Q9ULY7

UniProtKB/TrEMBL

A0A024R2J7, A0N0Q1

Related

ENSP00000332659.5, ENST00000330953.6

Conserved Domains (1) summary

cd14984
Location:40 → 315

7tmA_Chemokine_R; classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000003.12 Reference GRCh38.p14 Primary Assembly

Range

32951644..32956349

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017005687.2 → XP_016861176.1 C-C chemokine receptor type 4 isoform X1

UniProtKB/Swiss-Prot

P51679, Q9ULY6, Q9ULY7

UniProtKB/TrEMBL

A0A024R2J7, A0N0Q1

Conserved Domains (1) summary

cd14984
Location:40 → 315

7tmA_Chemokine_R; classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

Alternate T2T-CHM13v2.0

Genomic

NC_060927.1 Alternate T2T-CHM13v2.0

Range

32953438..32958143

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054345170.1 → XP_054201145.1 C-C chemokine receptor type 4 isoform X1

UniProtKB/Swiss-Prot

P51679, Q9ULY6, Q9ULY7

UniProtKB/TrEMBL

A0A024R2J7, A0N0Q1