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    Parp12 poly (ADP-ribose) polymerase family, member 12 [ Mus musculus (house mouse) ]

    Gene ID: 243771, updated on 8-May-2024

    Summary

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    Official Symbol
    Parp12provided by MGI
    Official Full Name
    poly (ADP-ribose) polymerase family, member 12provided by MGI
    Primary source
    MGI:MGI:2143990
    See related
    Ensembl:ENSMUSG00000038507 AllianceGenome:MGI:2143990
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ARTD12; PARP-12; Zc3hdc1; 9930021O16
    Summary
    Predicted to enable protein ADP-ribosylase activity. Predicted to be involved in protein auto-ADP-ribosylation and protein mono-ADP-ribosylation. Predicted to act upstream of or within protein ADP-ribosylation. Predicted to be located in nucleus. Is expressed in early conceptus; gallbladder; gut; metanephros; and reproductive system. Orthologous to human PARP12 (poly(ADP-ribose) polymerase family member 12). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in small intestine adult (RPKM 28.4), colon adult (RPKM 27.7) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Parp12 in Genome Data Viewer
    Location:
    6 B1; 6 17.85 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (39063346..39095283, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (39086412..39118349, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene thromboxane A synthase 1, platelet Neighboring gene RIKEN cDNA 1700025N23 gene Neighboring gene predicted gene, 46989 Neighboring gene RIKEN cDNA 4930599N23 gene Neighboring gene STARR-seq mESC enhancer starr_15629 Neighboring gene lysine (K)-specific demethylase 7A Neighboring gene STARR-positive B cell enhancer ABC_E3651 Neighboring gene STARR-seq mESC enhancer starr_15630 Neighboring gene STARR-positive B cell enhancer ABC_E6424 Neighboring gene predicted gene, 38794

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. PARP12 suppresses Zika virus infection through PARP-dependent degradation of NS1 and NS3 viral proteins. Li L, et al. Sci Signal, 2018 Jun 19. PMID 29921658, Free PMC Article
    2. PARP12, an interferon-stimulated gene involved in the control of protein translation and inflammation. Welsby I, et al. J Biol Chem, 2014 Sep 19. PMID 25086041, Free PMC Article
    3. Identification and characterization of human TIPARP gene within the CCNL amplicon at human chromosome 3q25.31. Katoh M, et al. Int J Oncol, 2003 Aug. PMID 12851707
    4. Interactome of vertebrate GAF/ThPOK reveals its diverse functions in gene regulation and DNA repair. Srivastava A, et al. J Biosci, 2020. PMID 32098917
    5. A global genomic transcriptional code associated with CNS-expressed genes. Bailey PJ, et al. Exp Cell Res, 2006 Oct 1. PMID 16919269

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PARP12 is required to repress the replication of a Mac1 mutant coronavirus in a cell- and tissue-specific manner.
      Title: PARP12 is required to repress the replication of a Mac1 mutant coronavirus in a cell- and tissue-specific manner.
    2. PARP12 regulates mouse oocyte meiotic maturation.
      Title: PARP12 regulates mouse oocyte meiotic maturation.
    3. To screen for antiviral IFN-stimulated genes that restricted Zika virus replication, and identified PARP12 as a strong inhibitor of Zika virus replication. Findings suggest that PARP12 mediated the ADP-ribosylation of NS1 and NS3, nonstructural viral proteins that are involved in viral replication and modulating host defense responses.
      Title: PARP12 suppresses Zika virus infection through PARP-dependent degradation of NS1 and NS3 viral proteins.
    4. PARP12 is an interferon-induced gene with a potential role in cellular defenses against viral infections.
      Title: PARP12, an interferon-stimulated gene involved in the control of protein translation and inflammation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NAD+ ADP-ribosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NAD+-protein ADP-ribosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NAD+-protein ADP-ribosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein auto-ADP-ribosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein mono-ADP-ribosyltransferase PARP12
    Names
    ADP-ribosyltransferase diphtheria toxin-like 12
    poly ADP-ribose polymerase 12
    poly [ADP-ribose] polymerase 12
    zinc finger CCCH domain-containing protein 1
    zinc finger CCCH type domain containing 1
    NP_766481.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172893.3 → NP_766481.2  protein mono-ADP-ribosyltransferase PARP12

      See identical proteins and their annotated locations for NP_766481.2

      Status: VALIDATED

      Source sequence(s)
      AK036886, BC048927, BC120733
      Consensus CDS
      CCDS20019.1
      UniProtKB/Swiss-Prot
      Q0VB94, Q80VL6, Q8BZ20, Q8K333, Q8R3U2
      UniProtKB/TrEMBL
      Q3U0S1
      Related
      ENSMUSP00000039704.7, ENSMUST00000038398.7
      Conserved Domains (5) summary
      smart00356
      Location:186 → 208
      ZnF_C3H1; zinc finger
      cd01439
      Location:571 → 687
      TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
      pfam00644
      Location:506 → 689
      PARP; Poly(ADP-ribose) polymerase catalytic domain
      pfam02825
      Location:387 → 468
      WWE; WWE domain
      cl02729
      Location:309 → 382
      WWE; WWE domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      39063346..39095283 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BZ20.3 GenPept UniProtKB/Swiss-Prot:Q8BZ20

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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