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    Lgi4 leucine-rich repeat LGI family, member 4 [ Mus musculus (house mouse) ]

    Gene ID: 243914, updated on 12-May-2024

    Summary

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    Official Symbol
    Lgi4provided by MGI
    Official Full Name
    leucine-rich repeat LGI family, member 4provided by MGI
    Primary source
    MGI:MGI:2180197
    See related
    Ensembl:ENSMUSG00000036560 AllianceGenome:MGI:2180197
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    clp; Lgil3
    Summary
    Involved in regulation of myelination. Acts upstream of or within adult locomotory behavior and neurogenesis. Located in extracellular space. Is expressed in several structures, including adipose tissue; alimentary system; nervous system; reproductive system; and sensory organ. Human ortholog(s) of this gene implicated in arthrogryposis multiplex congenita-1 and childhood absence epilepsy. Orthologous to human LGI4 (leucine rich repeat LGI family member 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in stomach adult (RPKM 10.9), bladder adult (RPKM 9.6) and 18 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Lgi4 in Genome Data Viewer
    Location:
    7 B1; 7 19.29 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (30758360..30770347)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (31058909..31070935)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38984 Neighboring gene FXYD domain-containing ion transport regulator 7 Neighboring gene FXYD domain-containing ion transport regulator 1 Neighboring gene FXYD domain-containing ion transport regulator 3 Neighboring gene predicted gene, 53358 Neighboring gene hepsin Neighboring gene STARR-positive B cell enhancer mm9_chr7:31896031-31896332

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Fxyd3 and Lgi4 expression in the adult mouse: a case of endogenous antisense expression. Runkel F, et al. Mamm Genome, 2003 Oct. PMID 14694902
    2. Evidence against altered forms of MAG in the dysmyelinated mouse mutant claw paw. Niemann S, et al. Mamm Genome, 1998 Nov. PMID 9799842
    3. The mouse mutation claw paw: forelimb deformity and delayed myelination throughout the peripheral nervous system. Henry EW, et al. J Hered, 1991 Jul-Aug. PMID 1652607
    4. Regional distribution of the leucine-rich glioma inactivated (LGI) gene family transcripts in the adult mouse brain. Herranz-Pérez V, et al. Brain Res, 2010 Jan 11. PMID 19833108
    5. The effect of the mouse mutation claw paw on myelination and nodal frequency in sciatic nerves. Koszowski AG, et al. J Neurosci, 1998 Aug 1. PMID 9671673, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Our results identify a new mechanism regulating enteric gliogenesis as well as novel functions for Lgi4 regulating the proliferation and maturation of glial lineage cells throughout the peripheral nervous system
      Title: Lgi4 promotes the proliferation and differentiation of glial lineage cells throughout the developing peripheral nervous system.
    2. lGI4 distribution in the vertical limb of the diagonal band and in putative hippocampal interneurons suggests that the function of these genes might be related to the generation of hippocampal theta rhythm.
      Title: Regional distribution of the leucine-rich glioma inactivated (LGI) gene family transcripts in the adult mouse brain.
    3. Fxyd3 and Lgi4 transcripts potentially form double-stranded RNA molecules in many cell types in vivo, which may impact on their respective expression
      Title: Fxyd3 and Lgi4 expression in the adult mouse: a case of endogenous antisense expression.
    4. the abnormalities observed in claw paw mice are attributable to the loss of Lgi4 function
      Title: The claw paw mutation reveals a role for Lgi4 in peripheral nerve development.
    Submit: New GeneRIF Correction

    Phenotypes

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    Associated conditions

    Description Tests
    claw paw
    GeneReviews: Not available

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Spontaneous (1) 
    • Targeted (5)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC107385

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within Schwann cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within adult locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within glial cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within glial cell proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within gliogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within gliogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within myelination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within myelination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in myelination in peripheral nervous system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within myelination in peripheral nervous system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within neuron maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of myelination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of myelination ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    leucine-rich repeat LGI family member 4
    Names
    LGI1-like protein 3
    leucine-rich glioma inactivated protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001419302.1 → NP_001406231.1  leucine-rich repeat LGI family member 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC149055, AC158993

    2. NM_144556.3 → NP_653139.2  leucine-rich repeat LGI family member 4 isoform 1 precursor

      See identical proteins and their annotated locations for NP_653139.2

      Status: VALIDATED

      Source sequence(s)
      AC149055, AC158993
      Consensus CDS
      CCDS21124.1
      UniProtKB/Swiss-Prot
      Q8K1S1, Q8K4Y8
      UniProtKB/TrEMBL
      Q3UYI9
      Related
      ENSMUSP00000041579.8, ENSMUST00000039775.9
      Conserved Domains (5) summary
      smart00082
      Location:158 → 206
      LRRCT; Leucine rich repeat C-terminal domain
      sd00031
      Location:54 → 77
      LRR_1; leucine-rich repeat [structural motif]
      pfam03736
      Location:396 → 438
      EPTP; EPTP domain
      pfam12799
      Location:102 → 140
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:76 → 136
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      30758360..30770347
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153096.1 → XP_036008989.1  leucine-rich repeat LGI family member 4 isoform X1

      UniProtKB/TrEMBL
      Q3UYI9
      Conserved Domains (4) summary
      TIGR00864
      Location:131 → 192
      PCC; polycystin cation channel protein
      sd00031
      Location:54 → 77
      LRR_1; leucine-rich repeat [structural motif]
      pfam03736
      Location:394 → 434
      EPTP; EPTP domain
      pfam13855
      Location:76 → 136
      LRR_8; Leucine rich repeat

    2. XM_011250576.4 → XP_011248878.1  leucine-rich repeat LGI family member 4 isoform X4

      Conserved Domains (3) summary
      TIGR00864
      Location:131 → 192
      PCC; polycystin cation channel protein
      sd00031
      Location:54 → 77
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:77 → 136
      LRR_8; Leucine rich repeat

    3. XM_006539958.5 → XP_006540021.2  leucine-rich repeat LGI family member 4 isoform X2

      See identical proteins and their annotated locations for XP_006540021.2

      UniProtKB/TrEMBL
      Q3UYI9
      Conserved Domains (4) summary
      TIGR00864
      Location:70 → 131
      PCC; polycystin cation channel protein
      sd00031
      Location:17 → 40
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:16 → 75
      LRR_8; Leucine rich repeat
      pfam03736
      Location:336 → 376
      EPTP; EPTP domain

    4. XM_036153097.1 → XP_036008990.1  leucine-rich repeat LGI family member 4 isoform X3

      Conserved Domains (1) summary
      pfam03736
      Location:162 → 202
      EPTP; EPTP domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K1S1.1 GenPept UniProtKB/Swiss-Prot:Q8K1S1

    Gene LinkOut

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