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    Zfp746 zinc finger protein 746 [ Mus musculus (house mouse) ]

    Gene ID: 69228, updated on 12-May-2024

    Summary

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    Official Symbol
    Zfp746provided by MGI
    Official Full Name
    zinc finger protein 746provided by MGI
    Primary source
    MGI:MGI:1916478
    See related
    Ensembl:ENSMUSG00000057691 AllianceGenome:MGI:1916478
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Znf746; 2810407L07Rik
    Summary
    Enables ubiquitin protein ligase binding activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of neuron death. Predicted to be located in cytosol and nucleoplasm. Is expressed in bladder; left lung epithelium; right lung epithelium; testis; and ureter. Orthologous to human ZNF746 (zinc finger protein 746). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in ovary adult (RPKM 14.4), thymus adult (RPKM 13.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp746 in Genome Data Viewer
    Location:
    6 B2.3; 6 23.04 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (48039325..48064275, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (48062391..48086986, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_15786 Neighboring gene nuclear encoded tRNA cysteine 57 (anticodon GCA) Neighboring gene STARR-seq mESC enhancer starr_15788 Neighboring gene zinc finger protein 777 Neighboring gene nuclear encoded tRNA cysteine 37 (anticodon GCA) Neighboring gene nuclear encoded tRNA cysteine 10 (anticodon GCA) Neighboring gene predicted gene, 30435 Neighboring gene predicted gene, 16630

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ZNF746/PARIS promotes the occurrence of hepatocellular carcinoma. Kim H, et al. Biochem Biophys Res Commun, 2021 Jul 23. PMID 34062393
    2. PARIS farnesylation prevents neurodegeneration in models of Parkinson's disease. Jo A, et al. Sci Transl Med, 2021 Jul 28. PMID 34321320, Free PMC Article
    3. Parkin interacting substrate zinc finger protein 746 is a pathological mediator in Parkinson's disease. Brahmachari S, et al. Brain, 2019 Aug 1. PMID 31237944, Free PMC Article
    4. Parkin loss leads to PARIS-dependent declines in mitochondrial mass and respiration. Stevens DA, et al. Proc Natl Acad Sci U S A, 2015 Sep 15. PMID 26324925, Free PMC Article
    5. Neuronal NLRP3 is a parkin substrate that drives neurodegeneration in Parkinson's disease. Panicker N, et al. Neuron, 2022 Aug 3. PMID 35654037, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Obesity-induced PARIS (ZNF746) accumulation in adipose progenitor cells leads to attenuated mitochondrial biogenesis and impaired adipogenesis.
      Title: Obesity-induced PARIS (ZNF746) accumulation in adipose progenitor cells leads to attenuated mitochondrial biogenesis and impaired adipogenesis.
    2. PARIS undergoes liquid-liquid phase separation and poly(ADP-ribose)-mediated solidification.
      Title: PARIS undergoes liquid-liquid phase separation and poly(ADP-ribose)-mediated solidification.
    3. ZNF746/PARIS promotes the occurrence of hepatocellular carcinoma.
      Title: ZNF746/PARIS promotes the occurrence of hepatocellular carcinoma.
    4. PARIS overexpression leads to reduced mitochondrial number and structural abnormalities
      Title: Parkin loss leads to PARIS-dependent declines in mitochondrial mass and respiration.
    5. Conditional knockout of parkin in adult animals leads to progressive loss of dopamine neurons in a PARIS-dependent manner.
      Title: PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's disease.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 746

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163475.1 → NP_001156947.1  zinc finger protein 746 isoform 1

      See identical proteins and their annotated locations for NP_001156947.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC166290
      Consensus CDS
      CCDS51762.1
      UniProtKB/Swiss-Prot
      E9QPR1, Q3U133
      Related
      ENSMUSP00000072868.7, ENSMUST00000073124.9
      Conserved Domains (6) summary
      cd07765
      Location:108 → 135
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      smart00349
      Location:107 → 156
      KRAB; krueppel associated box
      COG5048
      Location:518 → 596
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:519 → 539
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:573 → 595
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:531 → 555
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001347142.1 → NP_001334071.1  zinc finger protein 746 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AC166290
      Consensus CDS
      CCDS85036.1
      UniProtKB/TrEMBL
      A0A0N4SWG2
      Related
      ENSMUSP00000145506.2, ENSMUST00000203609.3

    3. NM_001362062.1 → NP_001348991.1  zinc finger protein 746 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses two alternate in-frame splice junctions and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC166290
      Conserved Domains (4) summary
      smart00349
      Location:111 → 171
      KRAB; krueppel associated box
      COG5048
      Location:490 → 568
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:491 → 511
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:545 → 567
      zf-C2H2; Zinc finger, C2H2 type

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      48039325..48064275 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036152290.1 → XP_036008183.1  zinc finger protein 746 isoform X12

      Conserved Domains (6) summary
      COG5048
      Location:479 → 557
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:480 → 500
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:534 → 556
      zf-C2H2; Zinc finger, C2H2 type
      pfam12417
      Location:25 → 81
      DUF3669; Zinc finger protein
      pfam13465
      Location:521 → 545
      zf-H2C2_2; Zinc-finger double domain
      cl02581
      Location:107 → 157
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

    2. XM_036152289.1 → XP_036008182.1  zinc finger protein 746 isoform X11

      Conserved Domains (6) summary
      COG5048
      Location:480 → 558
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:481 → 501
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:535 → 557
      zf-C2H2; Zinc finger, C2H2 type
      pfam12417
      Location:25 → 81
      DUF3669; Zinc finger protein
      pfam13465
      Location:522 → 546
      zf-H2C2_2; Zinc-finger double domain
      cl02581
      Location:107 → 157
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

    3. XM_036152291.1 → XP_036008184.1  zinc finger protein 746 isoform X14

      Conserved Domains (6) summary
      smart00349
      Location:107 → 156
      KRAB; krueppel associated box
      COG5048
      Location:475 → 553
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:476 → 496
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:530 → 552
      zf-C2H2; Zinc finger, C2H2 type
      pfam12417
      Location:25 → 81
      DUF3669; Zinc finger protein
      pfam13465
      Location:517 → 541
      zf-H2C2_2; Zinc-finger double domain

    4. XM_030255585.2 → XP_030111445.1  zinc finger protein 746 isoform X13

      Conserved Domains (6) summary
      smart00349
      Location:107 → 156
      KRAB; krueppel associated box
      COG5048
      Location:476 → 554
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:477 → 497
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:531 → 553
      zf-C2H2; Zinc finger, C2H2 type
      pfam12417
      Location:25 → 81
      DUF3669; Zinc finger protein
      pfam13465
      Location:518 → 542
      zf-H2C2_2; Zinc-finger double domain

    5. XM_006506559.5 → XP_006506622.1  zinc finger protein 746 isoform X6

      Conserved Domains (6) summary
      smart00349
      Location:107 → 156
      KRAB; krueppel associated box
      COG5048
      Location:524 → 602
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:525 → 545
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:579 → 601
      zf-C2H2; Zinc finger, C2H2 type
      pfam12417
      Location:25 → 81
      DUF3669; Zinc finger protein
      pfam13465
      Location:566 → 590
      zf-H2C2_2; Zinc-finger double domain

    6. XM_011241457.4 → XP_011239759.1  zinc finger protein 746 isoform X9

      Conserved Domains (6) summary
      COG5048
      Location:495 → 573
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:496 → 516
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:550 → 572
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:110 → 151
      KRAB; KRAB box
      pfam12417
      Location:25 → 81
      DUF3669; Zinc finger protein
      pfam13465
      Location:537 → 561
      zf-H2C2_2; Zinc-finger double domain

    7. XM_017321730.3 → XP_017177219.1  zinc finger protein 746 isoform X10

      Conserved Domains (6) summary
      smart00349
      Location:111 → 171
      KRAB; krueppel associated box
      COG5048
      Location:491 → 569
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:492 → 512
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:546 → 568
      zf-C2H2; Zinc finger, C2H2 type
      pfam12417
      Location:25 → 81
      DUF3669; Zinc finger protein
      pfam13465
      Location:533 → 557
      zf-H2C2_2; Zinc-finger double domain

    8. XM_030255584.2 → XP_030111444.1  zinc finger protein 746 isoform X4

      Conserved Domains (6) summary
      smart00349
      Location:111 → 171
      KRAB; krueppel associated box
      COG5048
      Location:532 → 610
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:533 → 553
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:587 → 609
      zf-C2H2; Zinc finger, C2H2 type
      pfam12417
      Location:25 → 81
      DUF3669; Zinc finger protein
      pfam13465
      Location:574 → 598
      zf-H2C2_2; Zinc-finger double domain

    9. XM_006506557.5 → XP_006506620.1  zinc finger protein 746 isoform X3

      Conserved Domains (6) summary
      smart00349
      Location:111 → 171
      KRAB; krueppel associated box
      COG5048
      Location:533 → 611
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:534 → 554
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:588 → 610
      zf-C2H2; Zinc finger, C2H2 type
      pfam12417
      Location:25 → 81
      DUF3669; Zinc finger protein
      pfam13465
      Location:575 → 599
      zf-H2C2_2; Zinc-finger double domain

    10. XM_011241456.4 → XP_011239758.1  zinc finger protein 746 isoform X8

      Conserved Domains (5) summary
      smart00349
      Location:111 → 171
      KRAB; krueppel associated box
      sd00017
      Location:497 → 517
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:551 → 573
      zf-C2H2; Zinc finger, C2H2 type
      pfam12417
      Location:25 → 81
      DUF3669; Zinc finger protein
      pfam13465
      Location:538 → 562
      zf-H2C2_2; Zinc-finger double domain

    11. XM_011241455.4 → XP_011239757.1  zinc finger protein 746 isoform X7

      Conserved Domains (5) summary
      smart00349
      Location:111 → 171
      KRAB; krueppel associated box
      sd00017
      Location:498 → 518
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:552 → 574
      zf-C2H2; Zinc finger, C2H2 type
      pfam12417
      Location:25 → 81
      DUF3669; Zinc finger protein
      pfam13465
      Location:539 → 563
      zf-H2C2_2; Zinc-finger double domain

    12. XM_011241454.4 → XP_011239756.1  zinc finger protein 746 isoform X2

      Conserved Domains (6) summary
      smart00349
      Location:111 → 171
      KRAB; krueppel associated box
      COG5048
      Location:538 → 616
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:539 → 559
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:593 → 615
      zf-C2H2; Zinc finger, C2H2 type
      pfam12417
      Location:25 → 81
      DUF3669; Zinc finger protein
      pfam13465
      Location:580 → 604
      zf-H2C2_2; Zinc-finger double domain

    13. XM_006506556.5 → XP_006506619.1  zinc finger protein 746 isoform X1

      Conserved Domains (6) summary
      smart00349
      Location:111 → 171
      KRAB; krueppel associated box
      COG5048
      Location:539 → 617
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:540 → 560
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:594 → 616
      zf-C2H2; Zinc finger, C2H2 type
      pfam12417
      Location:25 → 81
      DUF3669; Zinc finger protein
      pfam13465
      Location:581 → 605
      zf-H2C2_2; Zinc-finger double domain

    14. XM_036152288.1 → XP_036008181.1  zinc finger protein 746 isoform X5

      Conserved Domains (6) summary
      smart00349
      Location:98 → 158
      KRAB; krueppel associated box
      COG5048
      Location:526 → 604
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:527 → 547
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:581 → 603
      zf-C2H2; Zinc finger, C2H2 type
      pfam12417
      Location:12 → 68
      DUF3669; Zinc finger protein
      pfam13465
      Location:568 → 592
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3U133.3 GenPept UniProtKB/Swiss-Prot:Q3U133

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