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    Unc45b unc-45 myosin chaperone B [ Mus musculus (house mouse) ]

    Gene ID: 217012, updated on 12-May-2024

    Summary

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    Official Symbol
    Unc45bprovided by MGI
    Official Full Name
    unc-45 myosin chaperone Bprovided by MGI
    Primary source
    MGI:MGI:2443377
    See related
    Ensembl:ENSMUSG00000018845 AllianceGenome:MGI:2443377
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cmya4; Unc45; UNC-45B; D230041A13Rik
    Summary
    Enables Hsp90 protein binding activity. Acts upstream of or within chaperone-mediated protein folding. Located in cytosol. Is expressed in soleus and testis. Human ortholog(s) of this gene implicated in cataract 43 and myofibrillar myopathy. Orthologous to human UNC45B (unc-45 myosin chaperone B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in heart adult (RPKM 41.6), mammary gland adult (RPKM 6.5) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Unc45b in Genome Data Viewer
    Location:
    11 C; 11 50.3 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (82802112..82834284)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (82911253..82943406)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene fibronectin type III domain containing 8 Neighboring gene notchless homolog 1 Neighboring gene unc-45 myosin chaperone B, opposite strand Neighboring gene schlafen 5, opposite strand Neighboring gene schlafen 5 Neighboring gene SET domain-containing protein 8 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Chaperone-mediated reversible inhibition of the sarcomeric myosin power stroke. Nicholls P, et al. FEBS Lett, 2014 Nov 3. PMID 25240199
    2. Chaperone-enhanced purification of unconventional myosin 15, a molecular motor specialized for stereocilia protein trafficking. Bird JE, et al. Proc Natl Acad Sci U S A, 2014 Aug 26. PMID 25114250, Free PMC Article
    3. Unc45b forms a cytosolic complex with Hsp90 and targets the unfolded myosin motor domain. Srikakulam R, et al. PLoS One, 2008 May 14. PMID 18478096, Free PMC Article
    4. Unc45 activates Hsp90-dependent folding of the myosin motor domain. Liu L, et al. J Biol Chem, 2008 May 9. PMID 18326487, Free PMC Article
    5. Two mammalian UNC-45 isoforms are related to distinct cytoskeletal and muscle-specific functions. Price MG, et al. J Cell Sci, 2002 Nov 1. PMID 12356907

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (2)  1 citation
    • Endonuclease-mediated (1) 
    • Transgenic (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC91090

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables Hsp90 protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables Hsp90 protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chaperone-mediated protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within chaperone-mediated protein folding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within muscle organ development IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein unc-45 homolog B
    Names
    cardiomyopathy associated 4
    striated muscle UNC45
    unc-45 homolog B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001415076.1 → NP_001402005.1  protein unc-45 homolog B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL603745

    2. NM_178680.5 → NP_848795.3  protein unc-45 homolog B isoform 1

      See identical proteins and their annotated locations for NP_848795.3

      Status: VALIDATED

      Source sequence(s)
      AL603745
      Consensus CDS
      CCDS36251.1
      UniProtKB/Swiss-Prot
      Q5XG72, Q8BHC5, Q8BWK3, Q8CGY6
      Related
      ENSMUSP00000018989.8, ENSMUST00000018989.14
      Conserved Domains (5) summary
      cd00020
      Location:716 → 831
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      sd00006
      Location:6 → 34
      TPR; TPR repeat [structural motif]
      pfam11701
      Location:344 → 489
      UNC45-central; Myosin-binding striated muscle assembly central
      pfam13414
      Location:5 → 73
      TPR_11; TPR repeat
      sd00043
      Location:752 → 786
      ARM; armadillo repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      82802112..82834284
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CGY6.1 GenPept UniProtKB/Swiss-Prot:Q8CGY6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools