TRARG1 trafficking regulator of GLUT4 (SLC2A4) 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TRARG1provided by HGNC
Official Full Name: trafficking regulator of GLUT4 (SLC2A4) 1provided by HGNC
Primary source: HGNC:HGNC:29592
See related: Ensembl:ENSG00000184811 MIM:612211; AllianceGenome:HGNC:29592
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: BEC-1; DSPB1; LOST1; TUSC5; IFITMD3
Summary: Predicted to be involved in endosome to plasma membrane protein transport and glucose import in response to insulin stimulus. Predicted to act upstream of or within vesicle fusion to plasma membrane. Predicted to be located in cytoplasmic vesicle membrane and plasma membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward fat (RPKM 61.1) See more
Orthologs: mouse all
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Genomic context

Location:: 17p13.3

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (1279662..1300978)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (1171047..1192364)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (1182956..1204272)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Trafficking regulator of GLUT4-1 (TRARG1) is a GSK3 substrate.
Title: Trafficking regulator of GLUT4-1 (TRARG1) is a GSK3 substrate.
Low TUSC5 expression is associated with Breast Cancer.
Title: miR-3188 Regulates Cell Proliferation, Apoptosis, and Migration in Breast Cancer by Targeting TUSC5 and Regulating the p38 MAPK Signaling Pathway.
Aberrant DNA hypermethylation of TUSC5 in breast cancer suggests epigenetic mechanism of cancer associated down-regulation
Title: Hypermethylation of TUSC5 genes in breast cancer tissue.
These findings may point to participation of Tusc5 in shared adipose-nervous system functions.
Title: Characterization of Tusc5, an adipocyte gene co-expressed in peripheral neurons.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Process	Evidence Code	Pubs
involved_in cellular response to insulin stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in endosome to plasma membrane protein transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in glucose import in response to insulin stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization to plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in vesicle fusion to plasma membrane	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasmic vesicle membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in endomembrane system	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: trafficking regulator of GLUT4 1

Names: brain endothelial cell derived gene-1; dispanin subfamily B member 1; interferon induced transmembrane protein domain containing 3; interferon-induced transmembrane domain-containing protein D3; located at seventeen p thirteen point three 1; protein located at seventeen-p-thirteen point three 1; tumor suppressor candidate 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.