LMTK2 lemur tyrosine kinase 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: LMTK2provided by HGNC
Official Full Name: lemur tyrosine kinase 2provided by HGNC
Primary source: HGNC:HGNC:17880
See related: Ensembl:ENSG00000164715 MIM:610989; AllianceGenome:HGNC:17880
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: BREK; KPI2; LMR2; cprk; KPI-2; hBREK; AATYK2; PPP1R100
Summary: The protein encoded by this gene belongs to the protein kinase superfamily and the protein tyrosine kinase family. It contains N-terminal transmembrane helices and a long C-terminal cytoplasmic tail with serine/threonine/tyrosine kinase activity. This protein interacts with several other proteins, such as Inhibitor-2 (Inh2), protein phosphatase-1 (PP1C), p35, and myosin VI. It phosporylates other proteins, and is itself also phosporylated when interacting with cyclin-dependent kinase 5 (cdk5)/p35 complex. This protein involves in nerve growth factor (NGF)-TrkA signalling, and also plays a critical role in endosomal membrane trafficking. Mouse studies suggested an essential role of this protein in spermatogenesis. [provided by RefSeq, Oct 2009]
Expression: Ubiquitous expression in brain (RPKM 11.9), colon (RPKM 7.7) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 7q21.3

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (98106862..98209638)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (99335937..99439778)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (97736174..97838950)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lemur tyrosine kinase 2 has a tumor-inhibition function in human glioblastoma by regulating the RUNX3/Notch pathway.
Title: Lemur tyrosine kinase 2 has a tumor-inhibition function in human glioblastoma by regulating the RUNX3/Notch pathway.
Neuropathological characterization of Lemur tyrosine kinase 2 (LMTK2) in Alzheimer's disease and neocortical Lewy body disease.
Title: Neuropathological characterization of Lemur tyrosine kinase 2 (LMTK2) in Alzheimer's disease and neocortical Lewy body disease.
silencing of LMTK2 suppresses the proliferation and invasion of hepatocellular carcinoma cells.
Title: Silencing of lemur tyrosine kinase 2 restricts the proliferation and invasion of hepatocellular carcinoma through modulation of GSK-3β/Wnt/β-catenin signaling.
LMTK2 binds to KLC1 to direct axonal transport of p35 and its loss may contribute to Alzheimer's disease.
Title: LMTK2 binds to kinesin light chains to mediate anterograde axonal transport of cdk5/p35 and LMTK2 levels are reduced in Alzheimer's disease brains.
Our findings demonstrate that circLMTK2 functions as a tumour promoter in GC through the miR-150-5p/c-Myc axis and could thus be a prognostic predictor and therapeutic target for GC.
Title: circLMTK2 acts as a sponge of miR-150-5p and promotes proliferation and metastasis in gastric cancer.
both BIM and BCL2 proteins are regulated by LMTK2 in a GSK3beta- and PP1A-dependent manner.
Title: Lemur tyrosine kinase 2 (LMTK2) is a determinant of cell sensitivity to apoptosis by regulating the levels of the BCL2 family members.
Mutation of the di-acidic export motif led to endoplasmic reticulum retention of LMTK2, and an increase in protein half-life.
Title: Signal dependent ER export of lemur tyrosine kinase 2.
Lemur Tyrosine Kinase-2 (LMTK2), negatively regulates androgen-dependent and androgen-independent prostate cancer cell proliferation. In addition, LMTK2 also negatively regulates the androgen receptor transcriptional activity.
Title: Lemur Tyrosine Kinase 2, a novel target in prostate cancer therapy.
Data indicate that Lemur tyrosine kinase 2 (LMTK2) localizes at the plasma membrane and co-immunoprecipitates with cystic fibrosis transmembrane conductance regulator (CFTR) in airway epithelial cells.
Title: LMTK2-mediated phosphorylation regulates CFTR endocytosis in human airway epithelial cells.
The results indicate that lemur tyrosine kinase 2 is an integral membrane protein in which both the amino and carboxyl termini are exposed to the cytoplasm. Moreover, this topology places the kinase active site within the cytoplasm.
Title: Determination of the membrane topology of lemur tyrosine kinase 2 (LMTK2) by fluorescence protease protection.

Submit: New GeneRIF Correction See all GeneRIFs (24)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Identification of seven new prostate cancer susceptibility loci through a genome-wide association study. EBI GWAS Catalog EBI GWAS CatalogPubMed
Multiple newly identified loci associated with prostate cancer susceptibility. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH118588 (e-PCR)
- UniSTS:137987

A004H27 (e-PCR)
- UniSTS:63599

D12S335 (e-PCR), detects polymorphism
- UniSTS:65420

RH46467 (e-PCR)
- UniSTS:72660

RH103935 (e-PCR)
- UniSTS:98260

SHGC-149626 (e-PCR)
- UniSTS:177122

D15S1390 (e-PCR)
- UniSTS:474340

SGC33213 (e-PCR)
- UniSTS:31978

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	NAS Non-traceable Author Statement more info	PubMed
enables myosin VI binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein phosphatase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in early endosome to late endosome transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocytic recycling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-serine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidyl-threonine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in receptor recycling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transferrin transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in early endosome	IDA Inferred from Direct Assay more info	PubMed
located_in growth cone	IEA Inferred from Electronic Annotation more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in recycling endosome	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: serine/threonine-protein kinase LMTK2

Names: CDK5/p35-regulated kinase; apoptosis-associated tyrosine kinase 2; brain-enriched kinase; cyclin-dependent kinase 5/p35-regulated kinase; kinase/phosphatase/inhibitor 2; protein phosphatase 1, regulatory subunit 100; serine/threonine-protein kinase KPI-2

NP_055731.2

EC 2.7.11.1

XP_011514283.1

EC 2.7.11.1

XP_054213609.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_013375.1 RefSeqGene

Range

4978..107754

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_014916.4 → NP_055731.2 serine/threonine-protein kinase LMTK2 precursor

See identical proteins and their annotated locations for NP_055731.2

Status: REVIEWED

Source sequence(s)

AC073101, AC091654, AY130988, BC146773, BE049530

Consensus CDS

CCDS5654.1

UniProtKB/Swiss-Prot

A4D272, Q75MG7, Q8IWU2, Q9UPS3

Related

ENSP00000297293.5, ENST00000297293.6

Conserved Domains (2) summary

cd05086
Location:139 → 409

PTKc_Aatyk2; Catalytic domain of the Protein Tyrosine Kinase, Apoptosis-associated tyrosine kinase 2

pfam07714
Location:137 → 407

Pkinase_Tyr; Protein tyrosine kinase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000007.14 Reference GRCh38.p14 Primary Assembly

Range

98106862..98209638

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011515981.4 → XP_011514283.1 serine/threonine-protein kinase LMTK2 isoform X1

Conserved Domains (2) summary

cd05086
Location:137 → 407

PTKc_Aatyk2; Catalytic domain of the Protein Tyrosine Kinase, Apoptosis-associated tyrosine kinase 2

pfam07714
Location:135 → 405

Pkinase_Tyr; Protein tyrosine kinase