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    Cep55 centrosomal protein 55 [ Mus musculus (house mouse) ]

    Gene ID: 74107, updated on 12-May-2024

    Summary

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    Official Symbol
    Cep55provided by MGI
    Official Full Name
    centrosomal protein 55provided by MGI
    Primary source
    MGI:MGI:1921357
    See related
    Ensembl:ENSMUSG00000024989 AllianceGenome:MGI:1921357
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1200008O12Rik; 2700032M20Rik
    Summary
    Predicted to enable identical protein binding activity. Predicted to be involved in cranial skeletal system development; establishment of protein localization; and midbody abscission. Predicted to act upstream of or within cell division. Located in intercellular bridge and midbody. Is expressed in germ cell of testis and ovary. Human ortholog(s) of this gene implicated in multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia and hydranencephaly. Orthologous to human CEP55 (centrosomal protein 55). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in CNS E11.5 (RPKM 14.2), placenta adult (RPKM 6.0) and 11 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cep55 in Genome Data Viewer
    Location:
    19 C2; 19 32.69 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (38043423..38062873)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (38054970..38074425)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene myoferlin Neighboring gene predicted gene, 52397 Neighboring gene STARR-positive B cell enhancer mm9_chr19:38100719-38101020 Neighboring gene predicted gene, 52396 Neighboring gene STARR-seq mESC enhancer starr_46072 Neighboring gene STARR-positive B cell enhancer ABC_E971 Neighboring gene STARR-seq mESC enhancer starr_46073 Neighboring gene STARR-seq mESC enhancer starr_46074 Neighboring gene predicted gene, 23300 Neighboring gene free fatty acid receptor 4 Neighboring gene retinol binding protein 4, plasma

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. α-catenin interaction with YAP/FoxM1/TEAD-induced CEP55 supports liver cancer cell migration. Tang Y, et al. Cell Commun Signal, 2023 Jun 28. PMID 37381005, Free PMC Article
    2. Cep55 overexpression promotes genomic instability and tumorigenesis in mice. Sinha D, et al. Commun Biol, 2020 Oct 21. PMID 33087841, Free PMC Article
    3. Cep55 regulates spindle organization and cell cycle progression in meiotic oocyte. Xu ZY, et al. Sci Rep, 2015 Nov 19. PMID 26582107, Free PMC Article
    4. Knowing when to cut and run: mechanisms that control cytokinetic abscission. Agromayor M, et al. Trends Cell Biol, 2013 Sep. PMID 23706391
    5. CEP55 promotes cilia disassembly through stabilizing Aurora A kinase. Zhang YC, et al. J Cell Biol, 2021 Feb 1. PMID 33475699, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hsa-miR-195-5p Inhibits Autophagy and Gemcitabine Resistance of Lung Adenocarcinoma Cells via E2F7/CEP55.
      Title: Hsa-miR-195-5p Inhibits Autophagy and Gemcitabine Resistance of Lung Adenocarcinoma Cells via E2F7/CEP55.
    2. alpha-catenin interaction with YAP/FoxM1/TEAD-induced CEP55 supports liver cancer cell migration.
      Title: α-catenin interaction with YAP/FoxM1/TEAD-induced CEP55 supports liver cancer cell migration.
    3. MicroRNA-449a Suppresses Mouse Spermatogonia Proliferation via Inhibition of CEP55.
      Title: MicroRNA-449a Suppresses Mouse Spermatogonia Proliferation via Inhibition of CEP55.
    4. CEP55 promotes cilia disassembly through stabilizing Aurora A kinase.
      Title: CEP55 promotes cilia disassembly through stabilizing Aurora A kinase.
    5. Loss of Coiled-Coil Protein Cep55 Impairs Neural Stem Cell Abscission and Results in p53-Dependent Apoptosis in Developing Cortex.
      Title: Loss of Coiled-Coil Protein Cep55 Impairs Neural Stem Cell Abscission and Results in p53-Dependent Apoptosis in Developing Cortex.
    6. Cep55 overexpression promotes genomic instability and tumorigenesis in mice.
      Title: Cep55 overexpression promotes genomic instability and tumorigenesis in mice.
    7. This work defines Cep55 as an abscission regulator.
      Title: Cep55 promotes cytokinesis of neural progenitors but is dispensable for most mammalian cell divisions.
    8. Study found that Cep55-depleted mouse oocytes progress normally through early meiosis I, but that anaphase I fails as a result of persistent Cdk1 activity.
      Title: First meiotic anaphase requires Cep55-dependent inhibitory cyclin-dependent kinase 1 phosphorylation.
    9. that Cep55 overexpression causes change in germ cell proportions and manifests as a Sertoli cell only tubule phenotype
      Title: Cep55 overexpression causes male-specific sterility in mice by suppressing Foxo1 nuclear retention through sustained activation of PI3K/Akt signaling.
    10. Cep55 may act as an MTOC-associated protein regulating spindle organization, and thus cell cycle progression during mouse oocyte meiotic maturation.
      Title: Cep55 regulates spindle organization and cell cycle progression in meiotic oocyte.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cranial skeletal system development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in establishment of protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in establishment of protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in midbody abscission ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within mitotic cytokinesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Flemming body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intercellular bridge IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in midbody IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in midbody IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    centrosomal protein of 55 kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164362.2 → NP_001157834.1  centrosomal protein of 55 kDa isoform 1

      See identical proteins and their annotated locations for NP_001157834.1

      Status: VALIDATED

      Source sequence(s)
      AC101774, AK004655, AW538141
      Consensus CDS
      CCDS50429.1
      UniProtKB/Swiss-Prot
      Q8BT07, Q8C2J0, Q8K2I8, Q8R2Y4, Q9DBZ8
      Related
      ENSMUSP00000127961.2, ENSMUST00000169673.3
      Conserved Domains (2) summary
      COG1196
      Location:58 → 397
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam12180
      Location:171 → 204
      EABR; TSG101 and ALIX binding domain of CEP55

    2. NM_001360663.1 → NP_001347592.1  centrosomal protein of 55 kDa isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC101774
      Consensus CDS
      CCDS50429.1
      UniProtKB/Swiss-Prot
      Q8BT07, Q8C2J0, Q8K2I8, Q8R2Y4, Q9DBZ8
      Related
      ENSMUSP00000157898.2, ENSMUST00000236044.2
      Conserved Domains (2) summary
      COG1196
      Location:58 → 397
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam12180
      Location:171 → 204
      EABR; TSG101 and ALIX binding domain of CEP55

    3. NM_028293.2 → NP_082569.1  centrosomal protein of 55 kDa isoform 1

      See identical proteins and their annotated locations for NP_082569.1

      Status: VALIDATED

      Source sequence(s)
      AC101774, AK004655, AK028216, AW538141, CJ074252
      Consensus CDS
      CCDS50429.1
      UniProtKB/Swiss-Prot
      Q8BT07, Q8C2J0, Q8K2I8, Q8R2Y4, Q9DBZ8
      Related
      ENSMUSP00000093802.5, ENSMUST00000096096.12
      Conserved Domains (2) summary
      COG1196
      Location:58 → 397
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam12180
      Location:171 → 204
      EABR; TSG101 and ALIX binding domain of CEP55

    4. NM_028760.3 → NP_083036.2  centrosomal protein of 55 kDa isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC101774, AK004655, AW538141
      Consensus CDS
      CCDS29782.1
      UniProtKB/Swiss-Prot
      Q8BT07
      Related
      ENSMUSP00000157871.2, ENSMUST00000237408.2
      Conserved Domains (2) summary
      pfam12180
      Location:171 → 204
      EABR; TSG101 and ALIX binding domain of CEP55
      cl19219
      Location:256 → 332
      DUF342; Protein of unknown function (DUF342)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      38043423..38062873
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527396.3 → XP_006527459.1  centrosomal protein of 55 kDa isoform X1

      See identical proteins and their annotated locations for XP_006527459.1

      UniProtKB/Swiss-Prot
      Q8BT07, Q8C2J0, Q8K2I8, Q8R2Y4, Q9DBZ8
      Conserved Domains (2) summary
      COG1196
      Location:58 → 397
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam12180
      Location:171 → 204
      EABR; TSG101 and ALIX binding domain of CEP55

    2. XM_006527399.4 → XP_006527462.1  centrosomal protein of 55 kDa isoform X1

      See identical proteins and their annotated locations for XP_006527462.1

      UniProtKB/Swiss-Prot
      Q8BT07, Q8C2J0, Q8K2I8, Q8R2Y4, Q9DBZ8
      Conserved Domains (2) summary
      COG1196
      Location:58 → 397
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam12180
      Location:171 → 204
      EABR; TSG101 and ALIX binding domain of CEP55

    3. XM_006527401.2 → XP_006527464.1  centrosomal protein of 55 kDa isoform X1

      See identical proteins and their annotated locations for XP_006527464.1

      UniProtKB/Swiss-Prot
      Q8BT07, Q8C2J0, Q8K2I8, Q8R2Y4, Q9DBZ8
      Conserved Domains (2) summary
      COG1196
      Location:58 → 397
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam12180
      Location:171 → 204
      EABR; TSG101 and ALIX binding domain of CEP55

    4. XM_030251115.2 → XP_030106975.1  centrosomal protein of 55 kDa isoform X2

      Conserved Domains (2) summary
      COG1196
      Location:78 → 244
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam12180
      Location:17 → 50
      EABR; TSG101 and ALIX binding domain of CEP55

    5. XM_006527402.3 → XP_006527465.1  centrosomal protein of 55 kDa isoform X2

      Conserved Domains (2) summary
      COG1196
      Location:78 → 244
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam12180
      Location:17 → 50
      EABR; TSG101 and ALIX binding domain of CEP55

    6. XM_030251114.2 → XP_030106974.1  centrosomal protein of 55 kDa isoform X2

      Conserved Domains (2) summary
      COG1196
      Location:78 → 244
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam12180
      Location:17 → 50
      EABR; TSG101 and ALIX binding domain of CEP55

    7. XM_006527397.5 → XP_006527460.1  centrosomal protein of 55 kDa isoform X1

      See identical proteins and their annotated locations for XP_006527460.1

      UniProtKB/Swiss-Prot
      Q8BT07, Q8C2J0, Q8K2I8, Q8R2Y4, Q9DBZ8
      Conserved Domains (2) summary
      COG1196
      Location:58 → 397
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam12180
      Location:171 → 204
      EABR; TSG101 and ALIX binding domain of CEP55

    8. XM_011247381.4 → XP_011245683.1  centrosomal protein of 55 kDa isoform X1

      See identical proteins and their annotated locations for XP_011245683.1

      UniProtKB/Swiss-Prot
      Q8BT07, Q8C2J0, Q8K2I8, Q8R2Y4, Q9DBZ8
      Conserved Domains (2) summary
      COG1196
      Location:58 → 397
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam12180
      Location:171 → 204
      EABR; TSG101 and ALIX binding domain of CEP55

    9. XM_006527398.5 → XP_006527461.1  centrosomal protein of 55 kDa isoform X1

      See identical proteins and their annotated locations for XP_006527461.1

      UniProtKB/Swiss-Prot
      Q8BT07, Q8C2J0, Q8K2I8, Q8R2Y4, Q9DBZ8
      Conserved Domains (2) summary
      COG1196
      Location:58 → 397
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam12180
      Location:171 → 204
      EABR; TSG101 and ALIX binding domain of CEP55

    10. XM_036161710.1 → XP_036017603.1  centrosomal protein of 55 kDa isoform X1

      UniProtKB/Swiss-Prot
      Q8BT07, Q8C2J0, Q8K2I8, Q8R2Y4, Q9DBZ8
      Conserved Domains (2) summary
      COG1196
      Location:58 → 397
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam12180
      Location:171 → 204
      EABR; TSG101 and ALIX binding domain of CEP55

    11. XM_036161711.1 → XP_036017604.1  centrosomal protein of 55 kDa isoform X2

      Conserved Domains (2) summary
      COG1196
      Location:78 → 244
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam12180
      Location:17 → 50
      EABR; TSG101 and ALIX binding domain of CEP55

    12. XM_030251113.2 → XP_030106973.1  centrosomal protein of 55 kDa isoform X2

      Conserved Domains (2) summary
      COG1196
      Location:78 → 244
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam12180
      Location:17 → 50
      EABR; TSG101 and ALIX binding domain of CEP55

    13. XM_036161712.1 → XP_036017605.1  centrosomal protein of 55 kDa isoform X2

      Conserved Domains (2) summary
      COG1196
      Location:78 → 244
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam12180
      Location:17 → 50
      EABR; TSG101 and ALIX binding domain of CEP55
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BT07.2 GenPept UniProtKB/Swiss-Prot:Q8BT07

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