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    Galnt15 polypeptide N-acetylgalactosaminyltransferase 15 [ Mus musculus (house mouse) ]

    Gene ID: 78754, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Galnt15provided by MGI
    Official Full Name
    polypeptide N-acetylgalactosaminyltransferase 15provided by MGI
    Primary source
    MGI:MGI:1926004
    See related
    Ensembl:ENSMUSG00000021903 AllianceGenome:MGI:1926004
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Galntl2; 4631401E18Rik; mpp-GalNAc-T15
    Summary
    Predicted to enable carbohydrate binding activity; metal ion binding activity; and polypeptide N-acetylgalactosaminyltransferase activity. Predicted to be located in transport vesicle. Predicted to be active in Golgi apparatus. Is expressed in retina layer. Orthologous to human GALNT15 (polypeptide N-acetylgalactosaminyltransferase 15). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in subcutaneous fat pad adult (RPKM 11.9), ovary adult (RPKM 10.2) and 12 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Galnt15 in Genome Data Viewer
    Location:
    14 B; 14 19.4 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (31750739..31784161)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (32028782..32062204)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 57623 Neighboring gene predicted gene, 53841 Neighboring gene STARR-seq mESC enhancer starr_36333 Neighboring gene diphthamine biosynthesis 3 Neighboring gene oxidoreductase NAD-binding domain containing 1 Neighboring gene predicted gene, 57612

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Expression of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase isoforms in murine tissues determined by real-time PCR: a new view of a large family. Young WW Jr, et al. Glycobiology, 2003 Jul. PMID 12651884
    2. Galnt11 regulates kidney function by glycosylating the endocytosis receptor megalin to modulate ligand binding. Tian E, et al. Proc Natl Acad Sci U S A, 2019 Dec 10. PMID 31740596, Free PMC Article
    3. Loss of the disease-associated glycosyltransferase Galnt3 alters Muc10 glycosylation and the composition of the oral microbiome. Peluso G, et al. J Biol Chem, 2020 Jan 31. PMID 31882545, Free PMC Article
    4. Galnt1 is required for normal heart valve development and cardiac function. Tian E, et al. PLoS One, 2015. PMID 25615642, Free PMC Article
    5. MEGF10 and MEGF11 mediate homotypic interactions required for mosaic spacing of retinal neurons. Kay JN, et al. Nature, 2012 Mar 11. PMID 22407321, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables polypeptide N-acetylgalactosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in protein O-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in transport vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    polypeptide N-acetylgalactosaminyltransferase 15
    Names
    UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-like protein 2
    UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 15
    UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 2
    galNAc-T-like protein 2
    polypeptide GalNAc transferase-like protein 2
    polypeptide N-acetylgalactosaminyltransferase-like 2
    polypeptide N-acetylgalactosaminyltransferase-like protein 2
    pp-GaNTase-like protein 2
    protein-UDP acetylgalactosaminyltransferase-like protein 2
    NP_084442.1
    XP_006519762.1
    XP_036014800.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_030166.3 → NP_084442.1  polypeptide N-acetylgalactosaminyltransferase 15

      See identical proteins and their annotated locations for NP_084442.1

      Status: PROVISIONAL

      Source sequence(s)
      BC133711
      Consensus CDS
      CCDS36859.1
      UniProtKB/Swiss-Prot
      A3KN88, Q9D2N8
      UniProtKB/TrEMBL
      Q60GT1
      Related
      ENSMUSP00000022460.5, ENSMUST00000022460.11
      Conserved Domains (4) summary
      cd02510
      Location:194 → 492
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      cd00161
      Location:506 → 629
      RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
      pfam00652
      Location:504 → 627
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
      pfam13641
      Location:191 → 436
      Glyco_tranf_2_3; Glycosyltransferase like family 2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      31750739..31784161
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158907.1 → XP_036014800.1  polypeptide N-acetylgalactosaminyltransferase 15 isoform X2

      Conserved Domains (1) summary
      cl11394
      Location:194 → 359
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

    2. XM_006519699.5 → XP_006519762.1  polypeptide N-acetylgalactosaminyltransferase 15 isoform X1

      UniProtKB/TrEMBL
      Q60GT1
      Conserved Domains (2) summary
      cd02510
      Location:194 → 492
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      pfam00652
      Location:504 → 641
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

    RNA

    1. XR_004938460.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D2N8.1 GenPept UniProtKB/Swiss-Prot:Q9D2N8

    Gene LinkOut

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