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    Zfp131 zinc finger protein 131 [ Mus musculus (house mouse) ]

    Gene ID: 72465, updated on 12-May-2024

    Summary

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    Official Symbol
    Zfp131provided by MGI
    Official Full Name
    zinc finger protein 131provided by MGI
    Primary source
    MGI:MGI:1919715
    See related
    Ensembl:ENSMUSG00000094870 AllianceGenome:MGI:1919715
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Znf131; 2610109I01Rik
    Summary
    This gene encodes a member of the BTB/POZ family of transcription factors. This protein has been found to act as a transcriptional activator and may regulate estrogen receptor signaling. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 11.2), CNS E14 (RPKM 8.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp131 in Genome Data Viewer
    Location:
    13; 13 D2.3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (120226722..120253070, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (119765186..119791477, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 Neighboring gene NIM1 serine/threonine protein kinase Neighboring gene predicted gene, 52026 Neighboring gene predicted gene, 41077 Neighboring gene predicted gene, 23308 Neighboring gene Tcstv family member 7A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. BTB-ZF Protein Znf131 Regulates Cell Growth of Developing and Mature T Cells. Iguchi T, et al. J Immunol, 2015 Aug 1. PMID 26136427
    2. A BTB-ZF protein, ZNF131, is required for early B cell development. Iguchi T, et al. Biochem Biophys Res Commun, 2018 Jun 22. PMID 29750959
    3. The POZ-ZF transcription factor Znf131 is implicated as a regulator of Kaiso-mediated biological processes. Robinson SC, et al. Biochem Biophys Res Commun, 2017 Nov 4. PMID 28882591
    4. The murine BTB/POZ zinc finger gene Znf131: predominant expression in the developing central nervous system, in adult brain, testis, and thymus. Trappe R, et al. Biochem Biophys Res Commun, 2002 Aug 16. PMID 12163020
    5. Kaiso regulates Znf131-mediated transcriptional activation. Donaldson NS, et al. Exp Cell Res, 2010 Jun 10. PMID 20303951

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. YAP1-activated ZNF131 promotes hepatocellular carcinoma cell proliferation through transcriptional regulation of PAIP1.
      Title: YAP1-activated ZNF131 promotes hepatocellular carcinoma cell proliferation through transcriptional regulation of PAIP1.
    2. The BTB transcription factors ZBTB11 and ZFP131 maintain pluripotency by repressing pro-differentiation genes.
      Title: The BTB transcription factors ZBTB11 and ZFP131 maintain pluripotency by repressing pro-differentiation genes.
    3. ZNF131 suppresses expression of Cdk inhibitor, p21(cip1), and that of pro-apoptotic factors, Bax and Puma, targets of p53, to facilitate cell cycle progression and suppress unnecessary apoptosis, respectively, of pro-B cells.
      Title: A BTB-ZF protein, ZNF131, is required for early B cell development.
    4. We also demonstrate that Kaiso inhibits Znf131 expression, raising the possibility that Kaiso and Znf131 act to fine-tune target gene expression. Together, our findings implicate Znf131 as a co-regulator of Kaiso-mediated biological processes.
      Title: The POZ-ZF transcription factor Znf131 is implicated as a regulator of Kaiso-mediated biological processes.
    5. Znf131 is critical for T cell development during double-negative to double-positive stage, with which significant cell expansion triggered by the pre-TCR signal is coupled.
      Title: BTB-ZF Protein Znf131 Regulates Cell Growth of Developing and Mature T Cells.
    6. Znf131 is a transcriptional activator, a less common function of POZ-ZF proteins, that is negatively regulated by its heterodimerization partner Kaiso.
      Title: Kaiso regulates Znf131-mediated transcriptional activation.
    7. Results suggest that Znf131/ZNF131 plays a role during development and organogenesis as well as in the function of the adult central nervous system.
      Title: The murine BTB/POZ zinc finger gene Znf131: predominant expression in the developing central nervous system, in adult brain, testis, and thymus.
    8. The mechanism of Znf131 nuclear localization, is reported.
      Title: Nuclear trafficking of the POZ-ZF protein Znf131.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cytokine production IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of immune system process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in intermediate filament cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 131
    Names
    putative transcription factor ZNF131

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001302547.1 → NP_001289476.1  zinc finger protein 131 isoform 1

      See identical proteins and their annotated locations for NP_001289476.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1, also known as long isoform). Variants 1, 3 and 4 encode the same isoform (1).
      Source sequence(s)
      AK011832, AK030398, AK135723, AY092766, BE994245, BP765660
      Consensus CDS
      CCDS79245.1
      UniProtKB/Swiss-Prot
      Q3UYZ4, Q80UU7, Q8C8D0, Q8K3J5, Q9D042
      Conserved Domains (5) summary
      COG5048
      Location:262 → 444
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:290 → 311
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:422 → 439
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18221
      Location:16 → 128
      BTB_POZ_ZBTB35_ZNF131; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131)
      pfam13465
      Location:342 → 367
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001302548.1 → NP_001289477.1  zinc finger protein 131 isoform 2

      See identical proteins and their annotated locations for NP_001289477.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and lacks an in-frame portion of the 5' coding region compared to variant 1. Variants 2 and 5 encode the same isoform (2, also known as the short isoform), which is shorter than isoform 1.
      Source sequence(s)
      AK011832, AK030398, AK135723, AK162903, BP765660
      Consensus CDS
      CCDS56903.1
      UniProtKB/Swiss-Prot
      Q8K3J5
      Related
      ENSMUSP00000152941.2, ENSMUST00000223813.2
      Conserved Domains (5) summary
      COG5048
      Location:192 → 410
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:256 → 277
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:388 → 405
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18221
      Location:16 → 128
      BTB_POZ_ZBTB35_ZNF131; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131)
      pfam13465
      Location:308 → 333
      zf-H2C2_2; Zinc-finger double domain

    3. NM_001302549.1 → NP_001289478.1  zinc finger protein 131 isoform 1

      See identical proteins and their annotated locations for NP_001289478.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 3 and 4 encode the same isoform (1, also known as the long isoform).
      Source sequence(s)
      AK011832, AK030398, AK134257, AK135723, BP765660
      Consensus CDS
      CCDS79245.1
      UniProtKB/Swiss-Prot
      Q3UYZ4, Q80UU7, Q8C8D0, Q8K3J5, Q9D042
      Related
      ENSMUSP00000136867.2, ENSMUST00000177916.8
      Conserved Domains (5) summary
      COG5048
      Location:262 → 444
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:290 → 311
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:422 → 439
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18221
      Location:16 → 128
      BTB_POZ_ZBTB35_ZNF131; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131)
      pfam13465
      Location:342 → 367
      zf-H2C2_2; Zinc-finger double domain

    4. NM_001302550.1 → NP_001289479.1  zinc finger protein 131 isoform 1

      See identical proteins and their annotated locations for NP_001289479.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 3 and 4 encode the same isoform (1, also known as the long isoform).
      Source sequence(s)
      AK011832, AK030398, AK135723, BP765660, BY103805
      Consensus CDS
      CCDS79245.1
      UniProtKB/Swiss-Prot
      Q3UYZ4, Q80UU7, Q8C8D0, Q8K3J5, Q9D042
      Related
      ENSMUSP00000153044.2, ENSMUST00000223722.2
      Conserved Domains (5) summary
      COG5048
      Location:262 → 444
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:290 → 311
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:422 → 439
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18221
      Location:16 → 128
      BTB_POZ_ZBTB35_ZNF131; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131)
      pfam13465
      Location:342 → 367
      zf-H2C2_2; Zinc-finger double domain

    5. NM_028245.4 → NP_082521.1  zinc finger protein 131 isoform 2

      See identical proteins and their annotated locations for NP_082521.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and lacks an in-frame portion of the 5' coding region compared to variant 1. Variants 2 and 5 encode the same isoform (2, also known as the short isoform), which is shorter than isoform 1.
      Source sequence(s)
      AK011832, AK030398, AK134257, AK135723, BP765660
      Consensus CDS
      CCDS56903.1
      UniProtKB/Swiss-Prot
      Q8K3J5
      Related
      ENSMUSP00000136019.2, ENSMUST00000178271.3
      Conserved Domains (5) summary
      COG5048
      Location:192 → 410
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:256 → 277
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:388 → 405
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18221
      Location:16 → 128
      BTB_POZ_ZBTB35_ZNF131; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131)
      pfam13465
      Location:308 → 333
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      120226722..120253070 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017315610.3 → XP_017171099.1  zinc finger protein 131 isoform X2

      UniProtKB/Swiss-Prot
      Q8K3J5
      Conserved Domains (5) summary
      COG5048
      Location:192 → 410
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:256 → 277
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:388 → 405
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18221
      Location:16 → 128
      BTB_POZ_ZBTB35_ZNF131; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131)
      pfam13465
      Location:308 → 333
      zf-H2C2_2; Zinc-finger double domain

    2. XM_006517769.4 → XP_006517832.1  zinc finger protein 131 isoform X1

      See identical proteins and their annotated locations for XP_006517832.1

      UniProtKB/Swiss-Prot
      Q3UYZ4, Q80UU7, Q8C8D0, Q8K3J5, Q9D042
      Conserved Domains (5) summary
      COG5048
      Location:262 → 444
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:290 → 311
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:422 → 439
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18221
      Location:16 → 128
      BTB_POZ_ZBTB35_ZNF131; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131)
      pfam13465
      Location:342 → 367
      zf-H2C2_2; Zinc-finger double domain

    3. XM_030247417.2 → XP_030103277.1  zinc finger protein 131 isoform X2

      Conserved Domains (5) summary
      COG5048
      Location:192 → 410
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:256 → 277
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:388 → 405
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18221
      Location:16 → 128
      BTB_POZ_ZBTB35_ZNF131; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131)
      pfam13465
      Location:308 → 333
      zf-H2C2_2; Zinc-finger double domain

    4. XM_006517766.1 → XP_006517829.1  zinc finger protein 131 isoform X1

      See identical proteins and their annotated locations for XP_006517829.1

      UniProtKB/Swiss-Prot
      Q3UYZ4, Q80UU7, Q8C8D0, Q8K3J5, Q9D042
      Conserved Domains (5) summary
      COG5048
      Location:262 → 444
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:290 → 311
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:422 → 439
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18221
      Location:16 → 128
      BTB_POZ_ZBTB35_ZNF131; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131)
      pfam13465
      Location:342 → 367
      zf-H2C2_2; Zinc-finger double domain

    5. XM_011244698.3 → XP_011243000.1  zinc finger protein 131 isoform X3

      Conserved Domains (3) summary
      sd00017
      Location:190 → 211
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:322 → 339
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:242 → 267
      zf-H2C2_2; Zinc-finger double domain

    6. XM_036158183.1 → XP_036014076.1  zinc finger protein 131 isoform X4

      Conserved Domains (3) summary
      sd00017
      Location:156 → 177
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:288 → 305
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:208 → 233
      zf-H2C2_2; Zinc-finger double domain

    7. XM_036158184.1 → XP_036014077.1  zinc finger protein 131 isoform X5

      Conserved Domains (4) summary
      COG5048
      Location:1 → 165
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:11 → 32
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:143 → 160
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:63 → 88
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K3J5.1 GenPept UniProtKB/Swiss-Prot:Q8K3J5

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