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    Rslcan18 regulator of sex-limitation candidate 18 [ Mus musculus (house mouse) ]

    Gene ID: 432770, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Rslcan18provided by MGI
    Official Full Name
    regulator of sex-limitation candidate 18provided by MGI
    Primary source
    MGI:MGI:5433745
    See related
    Ensembl:ENSMUSG00000074824 AllianceGenome:MGI:5433745
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mszf51
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human ZNF429 (zinc finger protein 429). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See Rslcan18 in Genome Data Viewer
    Location:
    13; 13 B3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (67244677..67262092, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (67096613..67114028, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 712 Neighboring gene STARR-positive B cell enhancer ABC_E3085 Neighboring gene zinc finger protein 708 Neighboring gene STARR-positive B cell enhancer ABC_E9879 Neighboring gene uncharacterized LOC118568057 Neighboring gene tubulin, alpha 1B pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E1465 Neighboring gene zinc finger protein 759 Neighboring gene STARR-seq mESC enhancer starr_34894 Neighboring gene STARR-positive B cell enhancer ABC_E2411 Neighboring gene regulator of sex limited protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Regulator of sex-limitation (Rsl) encodes a pair of KRAB zinc-finger genes that control sexually dimorphic liver gene expression. Krebs CJ, et al. Genes Dev, 2003 Nov 1. PMID 14563677, Free PMC Article
    2. Rapid and efficient cloning of cDNAs encoding Krüppel-like zinc finger proteins by degenerate PCR. Agata Y, et al. Gene, 1998 Jun 15. PMID 9630514
    3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    regulator of sex-limitation candidate 18

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001256052.1 → NP_001242981.1  regulator of sex-limitation candidate 18

      See identical proteins and their annotated locations for NP_001242981.1

      Status: VALIDATED

      Source sequence(s)
      AC187103, BK001629
      Consensus CDS
      CCDS56890.1
      UniProtKB/TrEMBL
      Q7M6X5
      Related
      ENSMUSP00000089111.4, ENSMUST00000091526.4
      Conserved Domains (6) summary
      smart00349
      Location:96 → 154
      KRAB; krueppel associated box
      COG5048
      Location:168 → 458
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:173 → 193
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:367 → 389
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:96 → 135
      KRAB; KRAB box
      pfam13465
      Location:270 → 294
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      67244677..67262092 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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