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    Nlrp4g NLR family, pyrin domain containing 4G [ Mus musculus (house mouse) ]

    Gene ID: 235779, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Nlrp4gprovided by MGI
    Official Full Name
    NLR family, pyrin domain containing 4Gprovided by MGI
    Primary source
    MGI:MGI:3700744
    See related
    AllianceGenome:MGI:3700744
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    nalp4g; Gm47180; Gm47182
    Summary
    Located in cytosol. Is expressed in early conceptus and ovary. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See Nlrp4g in Genome Data Viewer
    Location:
    9; 9 F4
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (124101414..124137672, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (124348831..124356974)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39469 Neighboring gene RIKEN cDNA 2010315B03 gene Neighboring gene predicted gene, 20783 Neighboring gene RIKEN cDNA 4930526I15 gene Neighboring gene protein phosphatase 2 (formerly 2A), regulatory subunit B'', delta

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Expression and localization of Nlrp4g in mouse preimplantation embryo. Peng H, et al. Zygote, 2015 Dec. PMID 25384339
    2. Nlrp4g is an oocyte-specific gene but is not required for oocyte maturation in the mouse. Peng H, et al. Reprod Fertil Dev, 2014 Jun. PMID 23751860
    3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC91128

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    NLR family, pyrin domain containing 4G

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004145.3 → NP_001004145.1  NLR family, pyrin domain containing 4G isoform 2

      See identical proteins and their annotated locations for NP_001004145.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' coding region and UTR, compared to variant 1. The encoded isoform (2) has a shorter C-terminus, compared to isoform 1.
      Source sequence(s)
      AK136247, BC080833, CAAA01202134
      UniProtKB/TrEMBL
      Q66JP4
      Conserved Domains (2) summary
      cd08320
      Location:10 → 93
      Pyrin_NALPs; Pyrin death domain found in NALP proteins
      pfam05729
      Location:161 → 330
      NACHT; NACHT domain

    2. NM_001346422.2 → NP_001333351.2  NLR family, pyrin domain containing 4G isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      CAAA01202134, CAAA01216754, LXEJ02012085
      UniProtKB/TrEMBL
      Q3UWL9
      Conserved Domains (6) summary
      cd08320
      Location:10 → 93
      Pyrin_NALPs; Pyrin death domain found in NALP proteins
      sd00033
      Location:759 → 782
      LRR_RI; leucine-rich repeat [structural motif]
      pfam05729
      Location:158 → 327
      NACHT; NACHT domain
      pfam17776
      Location:461 → 574
      NLRC4_HD2; NLRC4 helical domain HD2
      pfam17779
      Location:403 → 459
      NOD2_WH; NOD2 winged helix domain
      cl39015
      Location:701 → 939
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      124101414..124137672 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036154927.1 → XP_036010820.1  NLR family, pyrin domain containing 4G isoform X3

      UniProtKB/TrEMBL
      Q3UWL9
      Conserved Domains (6) summary
      cd08320
      Location:10 → 92
      Pyrin_NALPs; Pyrin death domain found in NALP proteins
      sd00033
      Location:692 → 715
      LRR_RI; leucine-rich repeat [structural motif]
      pfam05729
      Location:148 → 317
      NACHT; NACHT domain
      pfam17776
      Location:451 → 564
      NLRC4_HD2; NLRC4 helical domain HD2
      pfam17779
      Location:393 → 449
      NOD2_WH; NOD2 winged helix domain
      cl39015
      Location:552 → 840
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    2. XM_036154926.1 → XP_036010819.1  NLR family, pyrin domain containing 4G isoform X2

      UniProtKB/TrEMBL
      Q3UWL9
      Conserved Domains (6) summary
      cd08320
      Location:10 → 92
      Pyrin_NALPs; Pyrin death domain found in NALP proteins
      sd00033
      Location:692 → 720
      LRR_RI; leucine-rich repeat [structural motif]
      pfam05729
      Location:148 → 317
      NACHT; NACHT domain
      pfam17776
      Location:451 → 564
      NLRC4_HD2; NLRC4 helical domain HD2
      pfam17779
      Location:393 → 449
      NOD2_WH; NOD2 winged helix domain
      cl39015
      Location:691 → 929
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    3. XM_036154925.1 → XP_036010818.1  NLR family, pyrin domain containing 4G isoform X1

      UniProtKB/TrEMBL
      Q3UWL9
      Conserved Domains (6) summary
      cd08320
      Location:10 → 93
      Pyrin_NALPs; Pyrin death domain found in NALP proteins
      sd00033
      Location:702 → 730
      LRR_RI; leucine-rich repeat [structural motif]
      pfam05729
      Location:158 → 327
      NACHT; NACHT domain
      pfam17776
      Location:461 → 574
      NLRC4_HD2; NLRC4 helical domain HD2
      pfam17779
      Location:403 → 459
      NOD2_WH; NOD2 winged helix domain
      cl39015
      Location:701 → 939
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    Nucleotide Protein Strain
    Heading Accession and Version

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