Ceacam2 CEA cell adhesion molecule 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ceacam2provided by MGI
Official Full Name: CEA cell adhesion molecule 2provided by MGI
Primary source: MGI:MGI:1347246
See related: Ensembl:ENSMUSG00000054385 AllianceGenome:MGI:1347246
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Bgp2; Ceacam2-L
Summary: Predicted to enable several functions, including cytoskeletal protein binding activity; enzyme binding activity; and protein dimerization activity. Acts upstream of or within energy homeostasis; negative regulation of brown fat cell proliferation; and negative regulation of feeding behavior. Located in external side of plasma membrane. Is expressed in metanephros; spleen; and testis. Orthologous to several human genes including CEACAM1 (CEA cell adhesion molecule 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in colon adult (RPKM 196.9), large intestine adult (RPKM 143.6) and 4 other tissues See more
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Genomic context

Location:: 7 A3; 7 13.87 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (25215467..25239429, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (25516042..25540004, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

disruption of CEACAM2 induces a moderate integrin alphaIIbbeta3-mediated platelet function defect, and that CEACAM2 is essential to maintain a normal integrin alphaIIbbeta3-mediated platelet function.
Title: CEACAM2 positively regulates integrin α(IIb)β(3)-mediated platelet functions.
CEACAM2 regulates insulin secretion, at least in part, by a GLP-1-mediated mechanism, independent of confounding metabolic factors.
Title: Increased Glucose-induced Secretion of Glucagon-like Peptide-1 in Mice Lacking the Carcinoembryonic Antigen-related Cell Adhesion Molecule 2 (CEACAM2).
Functional studies of platelets from Ceacam2(-/-)-deficient mice (Cc2(-/-)) revealed that CEACAM2 serves to negatively regulate collagen glycoprotein VI (platelet) (GPVI)-FcRgamma-chain and the C-type lectinlike receptor 2 (CLEC-2) signaling
Title: CEACAM2 negatively regulates hemi (ITAM-bearing) GPVI and CLEC-2 pathways and thrombus growth in vitro and in vivo.
Sertoli cells recognize the excess cytoplasm of elongated spermatids through the PVR-CEACAM2-L interaction in mouse testis
Title: CEACAM2-L on spermatids interacts with poliovirus receptor on Sertoli cells in mouse seminiferous epithelium.
CEACAM2-L might be a novel adhesion molecule contributing to cell-to-cell adhesion between elongating spermatids and Sertoli cells within the seminiferous epithelium
Title: Molecular cloning and localization of a CEACAM2 isoform, CEACAM2-L, expressed in spermatids in mouse testis.
Data suggest that CEACAM2 has a role in regulation of metabolic rate and insulin sensitivity/resistance via effects on brown adipogenesis, sympathetic nervous outflow to brown adipose tissue, and energy expenditure in skeletal muscle.
Title: Increased metabolic rate and insulin sensitivity in male mice lacking the carcino-embryonic antigen-related cell adhesion molecule 2.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1) 1 citation

General gene information

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Markers

D7Mit23 (e-PCR), detects polymorphism
- UniSTS:131123

AI267129 (e-PCR)
- UniSTS:159610

D7Dcr2 (e-PCR), detects polymorphism
- UniSTS:507776

Ceacam2 (e-PCR), detects polymorphism
- UniSTS:275683

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GPI anchor binding	ISO Inferred from Sequence Orthology more info
enables actin binding	ISO Inferred from Sequence Orthology more info
enables bile acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables calmodulin binding	ISO Inferred from Sequence Orthology more info
enables filamin binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables kinase binding	ISO Inferred from Sequence Orthology more info
enables protein dimerization activity	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein phosphatase binding	ISO Inferred from Sequence Orthology more info
enables protein tyrosine kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine kinase binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in bile acid and bile salt transport	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell-cell adhesion via plasma-membrane adhesion molecules	ISO Inferred from Sequence Orthology more info
involved_in cellular response to insulin stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within energy homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in insulin catabolic process	ISO Inferred from Sequence Orthology more info
involved_in insulin receptor internalization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of brown fat cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of fatty acid biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of feeding behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of hepatocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of homophilic cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in regulation of epidermal growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of homophilic cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in regulation of immune system process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of T cell receptor complex	ISO Inferred from Sequence Orthology more info
located_in adherens junction	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basal plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in lateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of transforming growth factor beta ligand-receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: carcinoembryonic antigen-related cell adhesion molecule 2

Names: BGP-2; CEA-related cell adhesion molecule 2; biliary glycoprotein 2; carcinoembryonic antigen-related cell adhesion molecule 2- Long

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001113368.1 → NP_001106839.1 carcinoembryonic antigen-related cell adhesion molecule 2 isoform a precursor

See identical proteins and their annotated locations for NP_001106839.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).

Source sequence(s)

AC162443

Consensus CDS

CCDS52153.1

UniProtKB/Swiss-Prot

D0VY57, E9QLI9, I7HDK2, Q61349, Q8R1N5, Q925P2

Related

ENSMUSP00000048118.9, ENSMUST00000044547.10

Conserved Domains (5) summary

cd00096
Location:342 → 346

Ig; Ig strand B [structural motif]

cd05740
Location:146 → 236

IgI_hCEACAM_2_4_6_like; Immunoglobulin (Ig)-like domain of human carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) domains 2, 4, and 6, and similar domains

cd05774
Location:36 → 140

IgV_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)

cd20948
Location:245 → 320

IgC2_CEACAM5-like; Fifth immunoglobulin (Ig)-like domain of the carcinoembryonic antigen (CEA) related cell adhesion molecule 5 (CEACAM5) and similar domains; member of the C2-set IgSF domains

cl11960
Location:326 → 413

Ig; Immunoglobulin domain
NM_001113369.1 → NP_001106840.1 carcinoembryonic antigen-related cell adhesion molecule 2 isoform b precursor

See identical proteins and their annotated locations for NP_001106840.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks alternate in-frame exons, compared to variant 1. This results in a shorter protein (isoform b), compared to isoform a.

Source sequence(s)

AC162443

Consensus CDS

CCDS52152.1

UniProtKB/Swiss-Prot

Q925P2

Related

ENSMUSP00000064255.8, ENSMUST00000066503.14

Conserved Domains (3) summary

cd05774
Location:36 → 140

Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)

smart00410
Location:153 → 232

IG_like; Immunoglobulin like

cl11960
Location:142 → 232

Ig; Immunoglobulin domain
NM_007543.4 → NP_031569.1 carcinoembryonic antigen-related cell adhesion molecule 2 isoform c precursor

See identical proteins and their annotated locations for NP_031569.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) has multiple differences in the coding region, compared to variant 1, one of which results in a translational frameshift and early stop codon. The resulting protein (isoform c) is shorter than isoform a.

Source sequence(s)

AC162443

Consensus CDS

CCDS20986.1

UniProtKB/Swiss-Prot

Q925P2

Related

ENSMUSP00000068540.7, ENSMUST00000064862.13

Conserved Domains (3) summary

cd05774
Location:36 → 140

Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)

smart00410
Location:153 → 232

IG_like; Immunoglobulin like

cl11960
Location:142 → 232

Ig; Immunoglobulin domain