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    Zfp251 zinc finger protein 251 [ Mus musculus (house mouse) ]

    Gene ID: 71591, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Zfp251provided by MGI
    Official Full Name
    zinc finger protein 251provided by MGI
    Primary source
    MGI:MGI:1918841
    See related
    Ensembl:ENSMUSG00000022526 AllianceGenome:MGI:1918841
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9130001M19Rik
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within hematopoietic stem cell homeostasis. Predicted to be active in nucleus. Is expressed in bladder; male associated reproductive structure; testis; ureter; and urethra of male. Orthologous to human ZNF251 (zinc finger protein 251). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 8.2), whole brain E14.5 (RPKM 7.9) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp251 in Genome Data Viewer
    Location:
    15 D3; 15 36.28 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (76736331..76755635, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (76852131..76871435, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 39 Neighboring gene predicted gene, 17271 Neighboring gene STARR-positive B cell enhancer ABC_E8939 Neighboring gene STARR-seq mESC enhancer starr_39062 Neighboring gene predicted gene, 41350 Neighboring gene STARR-positive B cell enhancer ABC_E11593 Neighboring gene STARR-positive B cell enhancer ABC_E2442 Neighboring gene zinc finger protein 7 Neighboring gene STARR-positive B cell enhancer ABC_E5492 Neighboring gene COMM domain containing 5 Neighboring gene ribosomal protein L8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Zinc finger protein 251 deficiency impairs glucose metabolism by inducing adipocyte hypertrophy. Kim E, et al. Mol Cell Endocrinol, 2023 Feb 15. PMID 36565788
    2. Functional screen identifies regulators of murine hematopoietic stem cell repopulation. Holmfeldt P, et al. J Exp Med, 2016 Mar 7. PMID 26880577, Free PMC Article
    3. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    4. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Zinc finger protein 251 deficiency impairs glucose metabolism by inducing adipocyte hypertrophy.
      Title: Zinc finger protein 251 deficiency impairs glucose metabolism by inducing adipocyte hypertrophy.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC69913

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within hematopoietic stem cell homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 251

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007568.2 → NP_001007569.1  zinc finger protein 251

      See identical proteins and their annotated locations for NP_001007569.1

      Status: PROVISIONAL

      Source sequence(s)
      AC157554
      Consensus CDS
      CCDS27593.1
      UniProtKB/TrEMBL
      Q3USU9, Q6PCX8
      Related
      ENSMUSP00000079268.6, ENSMUST00000080406.7
      Conserved Domains (6) summary
      smart00349
      Location:15 → 75
      KRAB; krueppel associated box
      COG5048
      Location:228 → 509
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:288 → 308
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:202 → 224
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:15 → 54
      KRAB; KRAB box
      pfam13465
      Location:356 → 381
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      76736331..76755635 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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