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    Plekhb2 pleckstrin homology domain containing B2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 301337, updated on 19-Jun-2024

    Summary

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    Official Symbol
    Plekhb2provided by RGD
    Official Full Name
    pleckstrin homology domain containing B2provided by RGD
    Primary source
    RGD:1310954
    See related
    Ensembl:ENSRNOG00000014162 AllianceGenome:RGD:1310954
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable phosphatidylinositol-3,4,5-trisphosphate binding activity. Predicted to be involved in regulation of cell differentiation. Predicted to be integral component of membrane. Orthologous to human PLEKHB2 (pleckstrin homology domain containing B2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 838.8), Brain (RPKM 757.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Plekhb2 in Genome Data Viewer
    Location:
    9q21
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (44545473..44578122)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (37049580..37082231)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (41348447..41381096)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene Rho guanine nucleotide exchange factor 4 Neighboring gene small integral membrane protein 39 Neighboring gene family with sequence similarity 168, member B Neighboring gene uncharacterized LOC120094662 Neighboring gene U1 spliceosomal RNA Neighboring gene ribosomal protein S14, pseudogene 2 Neighboring gene small nuclear ribonucleoprotein Sm D1-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities. Dowler S, et al. Biochem J, 2000 Oct 1. PMID 11001876, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables phosphatidylinositol-3,4,5-trisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    pleckstrin homology domain-containing family B member 2
    Names
    pleckstrin homology domain containing, family B (evectins) member 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106899.1 → NP_001100369.1  pleckstrin homology domain-containing family B member 2

      See identical proteins and their annotated locations for NP_001100369.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473965
      UniProtKB/TrEMBL
      A0A8I6AND6, A6INB3
      Related
      ENSRNOP00000019419.5, ENSRNOT00000019419.6
      Conserved Domains (3) summary
      cd13265
      Location:1 → 108
      PH_evt; Evectin Pleckstrin homology (PH) domain
      pfam00169
      Location:4 → 100
      PH; PH domain
      cl23782
      Location:126 → 186
      RCR; Chitin synthesis regulation, resistance to Congo red

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      44545473..44578122
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017596338.3 → XP_017451827.1  pleckstrin homology domain-containing family B member 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AND6, A6INB3
      Conserved Domains (3) summary
      cd13265
      Location:1 → 108
      PH_evt; Evectin Pleckstrin homology (PH) domain
      pfam00169
      Location:4 → 100
      PH; PH domain
      cl23782
      Location:126 → 186
      RCR; Chitin synthesis regulation, resistance to Congo red
    Nucleotide Protein Strain
    Heading Accession and Version

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