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    Capn15 calpain 15 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303000, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Capn15provided by RGD
    Official Full Name
    calpain 15provided by RGD
    Primary source
    RGD:1306514
    See related
    Ensembl:ENSRNOG00000020239 AllianceGenome:RGD:1306514
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Solh
    Summary
    Predicted to enable calcium-dependent cysteine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in cytoplasm. Orthologous to human CAPN15 (calpain 15). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 28.2), Thymus (RPKM 26.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Capn15 in Genome Data Viewer
    Location:
    10q12
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (15477311..15503913, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (14972807..14999411, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (15319772..15346607, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480763 Neighboring gene proline rich 35 Neighboring gene ribosomal protein L36A, pseudogene 7 Neighboring gene uncharacterized LOC120095052 Neighboring gene RAB11 family interacting protein 3 Neighboring gene uncharacterized LOC134480764

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium-dependent cysteine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    calpain-15
    Names
    small optic lobes homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106990.1 → NP_001100460.1  calpain-15

      See identical proteins and their annotated locations for NP_001100460.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473948
      UniProtKB/TrEMBL
      A6HD81, D3ZJJ4
      Related
      ENSRNOP00000027430.5, ENSRNOT00000027430.7
      Conserved Domains (4) summary
      smart00547
      Location:416 → 440
      ZnF_RBZ; Zinc finger domain
      cd00044
      Location:478 → 793
      CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
      sd00025
      Location:383 → 398
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      sd00029
      Location:346 → 365
      zf-RanBP2; RanBP2-type Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      15477311..15503913 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063268943.1 → XP_063125013.1  calpain-15 isoform X6

      UniProtKB/TrEMBL
      D3ZJJ4

    2. XM_063268939.1 → XP_063125009.1  calpain-15 isoform X2

      UniProtKB/TrEMBL
      A0A0G2KAS0, D3ZJJ4

    3. XM_063268941.1 → XP_063125011.1  calpain-15 isoform X4

      UniProtKB/TrEMBL
      D3ZJJ4

    4. XM_063268940.1 → XP_063125010.1  calpain-15 isoform X3

      UniProtKB/TrEMBL
      D3ZJJ4

    5. XM_063268938.1 → XP_063125008.1  calpain-15 isoform X1

      UniProtKB/TrEMBL
      D3ZJJ4

    6. XM_063268937.1 → XP_063125007.1  calpain-15 isoform X1

      UniProtKB/TrEMBL
      D3ZJJ4

    7. XM_063268942.1 → XP_063125012.1  calpain-15 isoform X5

      UniProtKB/TrEMBL
      D3ZJJ4
    Nucleotide Protein Strain
    Heading Accession and Version

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